Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Arquivos de Endocrinologia e Metabolismo (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000400364 |
Resumo: | Resistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and clinical datas. Thyroid nodule was palpated on physical examination. Thyroid ultrasonography showed multiple nodules in both lobes. Total thyroidectomy was performed. The pathological findings were consistent with papillary thyroid microcarcinoma. BRAFV600E mutation analysis results were negative. RTH is very rare and might be overlooked. There is no consensus on how to overcome the persistently high TSH in patients with RTH and differentiated thyroid cancer (DTC). Further studies are needed to explain the relationship between RTH and DTC which might be helpful for the treatment of these patients. |
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Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation statusResistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and clinical datas. Thyroid nodule was palpated on physical examination. Thyroid ultrasonography showed multiple nodules in both lobes. Total thyroidectomy was performed. The pathological findings were consistent with papillary thyroid microcarcinoma. BRAFV600E mutation analysis results were negative. RTH is very rare and might be overlooked. There is no consensus on how to overcome the persistently high TSH in patients with RTH and differentiated thyroid cancer (DTC). Further studies are needed to explain the relationship between RTH and DTC which might be helpful for the treatment of these patients.Sociedade Brasileira de Endocrinologia e Metabologia2015-08-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000400364Archives of Endocrinology and Metabolism v.59 n.4 2015reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/2359-3997000000091info:eu-repo/semantics/openAccessKarakose,MeliaCaliskan,MustafaArslan,Muyesser SaykiCakal,ErmanYesilyurt,AhmetDelibasi,Tuncayeng2015-08-27T00:00:00Zoai:scielo:S2359-39972015000400364Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2015-08-27T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
spellingShingle |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status Karakose,Melia |
title_short |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title_full |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title_fullStr |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title_full_unstemmed |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
title_sort |
Thyroid hormone resistance in two patients with papillary thyroid microcarcinoma and their BRAFV600E mutation status |
author |
Karakose,Melia |
author_facet |
Karakose,Melia Caliskan,Mustafa Arslan,Muyesser Sayki Cakal,Erman Yesilyurt,Ahmet Delibasi,Tuncay |
author_role |
author |
author2 |
Caliskan,Mustafa Arslan,Muyesser Sayki Cakal,Erman Yesilyurt,Ahmet Delibasi,Tuncay |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Karakose,Melia Caliskan,Mustafa Arslan,Muyesser Sayki Cakal,Erman Yesilyurt,Ahmet Delibasi,Tuncay |
description |
Resistance to thyroid hormone (RTH) is a rare autosomal dominant hereditary disorder. Here in, we report two patients with RTH in whom differentiated thyroid cancer was diagnosed. Two patients were admitted to our clinic and their laboratory results were elevated thyroid hormone levels with unsuppressed TSH. We considered this situation thyroid hormone resistance in the light of laboratory and clinical datas. Thyroid nodule was palpated on physical examination. Thyroid ultrasonography showed multiple nodules in both lobes. Total thyroidectomy was performed. The pathological findings were consistent with papillary thyroid microcarcinoma. BRAFV600E mutation analysis results were negative. RTH is very rare and might be overlooked. There is no consensus on how to overcome the persistently high TSH in patients with RTH and differentiated thyroid cancer (DTC). Further studies are needed to explain the relationship between RTH and DTC which might be helpful for the treatment of these patients. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000400364 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000400364 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2359-3997000000091 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Archives of Endocrinology and Metabolism v.59 n.4 2015 reponame:Arquivos de Endocrinologia e Metabolismo (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos de Endocrinologia e Metabolismo (Online) |
collection |
Arquivos de Endocrinologia e Metabolismo (Online) |
repository.name.fl_str_mv |
Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||aem.editorial.office@endocrino.org.br |
_version_ |
1752122513451646976 |