Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort study

Detalhes bibliográficos
Autor(a) principal: Rosinha,Patrícia Mendonça Oliveira
Data de Publicação: 2022
Outros Autores: Dantas,Rosa Alexandra Barbosa, Alves,Márcia Inês Paiva, Azevedo,Teresa Cristina Maia Ferreira, Inácio,Isabel Maria Ramos, Ferreira,Sara Gabriela Esteves, Pedrosa,Carla Alexandra Vieira, Ferreira,Marília Sousa, Sousa,Isabel Maria Albuquerque, Costa,Joana Guimarães Martins da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de Endocrinologia e Metabolismo (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005004205
Resumo: ABSTRACT Objective: To evaluate the influence of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on blood glucose levels at diagnosis of gestational diabetes mellitus (GDM) and obstetric/neonatal outcomes. Subjects and methods: Retrospective cohort study including 462 women with GDM and singleton pregnancy delivered in our institution between January 2015 and June 2018 and grouped according to BMI/GWG. Results: The diagnosis of GDM was more likely to be established in the 1st trimester (T) in women with obesity than in normal-weight (55.8% vs 53.7%, p = 0.008). BMI positively and significantly correlated with fasting plasma glucose (FPG) levels in the 1stT (rs = 0.213, p = 0.001) and 2ndT (rs = 0.210, p = 0.001). Excessive GWG occurred in 44.9% women with overweight and in 40.2% with obesity (p < 0.001). From women with obesity, 65.1% required pharmacological treatment (p < 0.001). Gestational hypertension (GH) was more frequent in women with obesity (p = 0.016). During follow-up, 132 cesareans were performed, the majority in mothers with obesity (p = 0.008). Of the 17 large-for-gestational-age (LGA) birthweight delivered, respectively 6 and 9 were offsprings of women with overweight and obesity (p = 0.019). Maternal BMI had a predictive value only for macrosomia [aOR 1.177 (1.006-1.376), p = 0.041]. BMI and GWG positively correlated with birthweight (rs = 0.132, p = 0.005; rs = 0.188, p = 0.005). Conclusion: Maternal obesity is related with a major probability of diagnosis of GDM in 1stT, fasting hyperglycemia in 2ndT and a more frequent need for pharmacological therapy. Pre-gestational obesity is associated with GH, cesarean delivery and fetal macrosomia.
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spelling Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort studyGestational diabetesbody mass indexgestational weight gainmaternal obesityblood glucose levelsABSTRACT Objective: To evaluate the influence of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on blood glucose levels at diagnosis of gestational diabetes mellitus (GDM) and obstetric/neonatal outcomes. Subjects and methods: Retrospective cohort study including 462 women with GDM and singleton pregnancy delivered in our institution between January 2015 and June 2018 and grouped according to BMI/GWG. Results: The diagnosis of GDM was more likely to be established in the 1st trimester (T) in women with obesity than in normal-weight (55.8% vs 53.7%, p = 0.008). BMI positively and significantly correlated with fasting plasma glucose (FPG) levels in the 1stT (rs = 0.213, p = 0.001) and 2ndT (rs = 0.210, p = 0.001). Excessive GWG occurred in 44.9% women with overweight and in 40.2% with obesity (p < 0.001). From women with obesity, 65.1% required pharmacological treatment (p < 0.001). Gestational hypertension (GH) was more frequent in women with obesity (p = 0.016). During follow-up, 132 cesareans were performed, the majority in mothers with obesity (p = 0.008). Of the 17 large-for-gestational-age (LGA) birthweight delivered, respectively 6 and 9 were offsprings of women with overweight and obesity (p = 0.019). Maternal BMI had a predictive value only for macrosomia [aOR 1.177 (1.006-1.376), p = 0.041]. BMI and GWG positively correlated with birthweight (rs = 0.132, p = 0.005; rs = 0.188, p = 0.005). Conclusion: Maternal obesity is related with a major probability of diagnosis of GDM in 1stT, fasting hyperglycemia in 2ndT and a more frequent need for pharmacological therapy. Pre-gestational obesity is associated with GH, cesarean delivery and fetal macrosomia.Sociedade Brasileira de Endocrinologia e Metabologia2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005004205Archives of Endocrinology and Metabolism n.ahead 2022reponame:Arquivos de Endocrinologia e Metabolismo (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.20945/2359-3997000000463info:eu-repo/semantics/openAccessRosinha,Patrícia Mendonça OliveiraDantas,Rosa Alexandra BarbosaAlves,Márcia Inês PaivaAzevedo,Teresa Cristina Maia FerreiraInácio,Isabel Maria RamosFerreira,Sara Gabriela EstevesPedrosa,Carla Alexandra VieiraFerreira,Marília SousaSousa,Isabel Maria AlbuquerqueCosta,Joana Guimarães Martins daeng2022-05-16T00:00:00Zoai:scielo:S2359-39972022005004205Revistahttps://www.aem-sbem.com/https://old.scielo.br/oai/scielo-oai.php||aem.editorial.office@endocrino.org.br2359-42922359-3997opendoar:2022-05-16T00:00Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort study
title Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort study
spellingShingle Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort study
Rosinha,Patrícia Mendonça Oliveira
Gestational diabetes
body mass index
gestational weight gain
maternal obesity
blood glucose levels
title_short Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort study
title_full Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort study
title_fullStr Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort study
title_full_unstemmed Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort study
title_sort Body mass index and gestational weight gain: relevance in gestational diabetes and outcomes - A retrospective cohort study
author Rosinha,Patrícia Mendonça Oliveira
author_facet Rosinha,Patrícia Mendonça Oliveira
Dantas,Rosa Alexandra Barbosa
Alves,Márcia Inês Paiva
Azevedo,Teresa Cristina Maia Ferreira
Inácio,Isabel Maria Ramos
Ferreira,Sara Gabriela Esteves
Pedrosa,Carla Alexandra Vieira
Ferreira,Marília Sousa
Sousa,Isabel Maria Albuquerque
Costa,Joana Guimarães Martins da
author_role author
author2 Dantas,Rosa Alexandra Barbosa
Alves,Márcia Inês Paiva
Azevedo,Teresa Cristina Maia Ferreira
Inácio,Isabel Maria Ramos
Ferreira,Sara Gabriela Esteves
Pedrosa,Carla Alexandra Vieira
Ferreira,Marília Sousa
Sousa,Isabel Maria Albuquerque
Costa,Joana Guimarães Martins da
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rosinha,Patrícia Mendonça Oliveira
Dantas,Rosa Alexandra Barbosa
Alves,Márcia Inês Paiva
Azevedo,Teresa Cristina Maia Ferreira
Inácio,Isabel Maria Ramos
Ferreira,Sara Gabriela Esteves
Pedrosa,Carla Alexandra Vieira
Ferreira,Marília Sousa
Sousa,Isabel Maria Albuquerque
Costa,Joana Guimarães Martins da
dc.subject.por.fl_str_mv Gestational diabetes
body mass index
gestational weight gain
maternal obesity
blood glucose levels
topic Gestational diabetes
body mass index
gestational weight gain
maternal obesity
blood glucose levels
description ABSTRACT Objective: To evaluate the influence of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on blood glucose levels at diagnosis of gestational diabetes mellitus (GDM) and obstetric/neonatal outcomes. Subjects and methods: Retrospective cohort study including 462 women with GDM and singleton pregnancy delivered in our institution between January 2015 and June 2018 and grouped according to BMI/GWG. Results: The diagnosis of GDM was more likely to be established in the 1st trimester (T) in women with obesity than in normal-weight (55.8% vs 53.7%, p = 0.008). BMI positively and significantly correlated with fasting plasma glucose (FPG) levels in the 1stT (rs = 0.213, p = 0.001) and 2ndT (rs = 0.210, p = 0.001). Excessive GWG occurred in 44.9% women with overweight and in 40.2% with obesity (p < 0.001). From women with obesity, 65.1% required pharmacological treatment (p < 0.001). Gestational hypertension (GH) was more frequent in women with obesity (p = 0.016). During follow-up, 132 cesareans were performed, the majority in mothers with obesity (p = 0.008). Of the 17 large-for-gestational-age (LGA) birthweight delivered, respectively 6 and 9 were offsprings of women with overweight and obesity (p = 0.019). Maternal BMI had a predictive value only for macrosomia [aOR 1.177 (1.006-1.376), p = 0.041]. BMI and GWG positively correlated with birthweight (rs = 0.132, p = 0.005; rs = 0.188, p = 0.005). Conclusion: Maternal obesity is related with a major probability of diagnosis of GDM in 1stT, fasting hyperglycemia in 2ndT and a more frequent need for pharmacological therapy. Pre-gestational obesity is associated with GH, cesarean delivery and fetal macrosomia.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005004205
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005004205
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.20945/2359-3997000000463
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Archives of Endocrinology and Metabolism n.ahead 2022
reponame:Arquivos de Endocrinologia e Metabolismo (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos de Endocrinologia e Metabolismo (Online)
collection Arquivos de Endocrinologia e Metabolismo (Online)
repository.name.fl_str_mv Arquivos de Endocrinologia e Metabolismo (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||aem.editorial.office@endocrino.org.br
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