Metabolic disturbances linked to obesity: the role of impaired tissue perfusion

Detalhes bibliográficos
Autor(a) principal: Villela,Nivaldo Ribeiro
Data de Publicação: 2009
Outros Autores: Kramer-Aguiar,Luiz Guilherme, Bottino,Daniel Alexandre, Wiernsperger,Nicolas, Bouskela,Eliete
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200015
Resumo: Associated with elevated risk of cardiovascular events and cancer, obesity is a worldwide problem affecting developed and developing countries. Microcirculatory vessels, represented by arterioles, capillaries and venules (mean internal diameter < 100 µm), are the place where blood/tissue nutrition and exchange effectively take place. Microvascular dysfunction is an early event in obesity probably secondary to endothelial dysfunction and capillaries rarefaction. New research techniques allow the investigation of the microcirculation in different vascular beds in humans. Studies suggest a link between endothelial dysfunction and visceral obesity. Oxidative stress, inflammation and rennin-angiotensin system are among factors considered to be involved on microvascular dysfunction in obesity. Microcirculatory impairment present in obesity suggests that it could be an important causal factor in obesity-related disorders such as insulin resistance and hypertension.
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spelling Metabolic disturbances linked to obesity: the role of impaired tissue perfusionObesityendothelial dysfunctionmicrocirculationtissue perfusionmetabolic syndromeAssociated with elevated risk of cardiovascular events and cancer, obesity is a worldwide problem affecting developed and developing countries. Microcirculatory vessels, represented by arterioles, capillaries and venules (mean internal diameter < 100 µm), are the place where blood/tissue nutrition and exchange effectively take place. Microvascular dysfunction is an early event in obesity probably secondary to endothelial dysfunction and capillaries rarefaction. New research techniques allow the investigation of the microcirculation in different vascular beds in humans. Studies suggest a link between endothelial dysfunction and visceral obesity. Oxidative stress, inflammation and rennin-angiotensin system are among factors considered to be involved on microvascular dysfunction in obesity. Microcirculatory impairment present in obesity suggests that it could be an important causal factor in obesity-related disorders such as insulin resistance and hypertension.Sociedade Brasileira de Endocrinologia e Metabologia2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200015Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.53 n.2 2009reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302009000200015info:eu-repo/semantics/openAccessVillela,Nivaldo RibeiroKramer-Aguiar,Luiz GuilhermeBottino,Daniel AlexandreWiernsperger,NicolasBouskela,Elieteeng2015-07-02T00:00:00Zoai:scielo:S0004-27302009000200015Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2015-07-02T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Metabolic disturbances linked to obesity: the role of impaired tissue perfusion
title Metabolic disturbances linked to obesity: the role of impaired tissue perfusion
spellingShingle Metabolic disturbances linked to obesity: the role of impaired tissue perfusion
Villela,Nivaldo Ribeiro
Obesity
endothelial dysfunction
microcirculation
tissue perfusion
metabolic syndrome
title_short Metabolic disturbances linked to obesity: the role of impaired tissue perfusion
title_full Metabolic disturbances linked to obesity: the role of impaired tissue perfusion
title_fullStr Metabolic disturbances linked to obesity: the role of impaired tissue perfusion
title_full_unstemmed Metabolic disturbances linked to obesity: the role of impaired tissue perfusion
title_sort Metabolic disturbances linked to obesity: the role of impaired tissue perfusion
author Villela,Nivaldo Ribeiro
author_facet Villela,Nivaldo Ribeiro
Kramer-Aguiar,Luiz Guilherme
Bottino,Daniel Alexandre
Wiernsperger,Nicolas
Bouskela,Eliete
author_role author
author2 Kramer-Aguiar,Luiz Guilherme
Bottino,Daniel Alexandre
Wiernsperger,Nicolas
Bouskela,Eliete
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Villela,Nivaldo Ribeiro
Kramer-Aguiar,Luiz Guilherme
Bottino,Daniel Alexandre
Wiernsperger,Nicolas
Bouskela,Eliete
dc.subject.por.fl_str_mv Obesity
endothelial dysfunction
microcirculation
tissue perfusion
metabolic syndrome
topic Obesity
endothelial dysfunction
microcirculation
tissue perfusion
metabolic syndrome
description Associated with elevated risk of cardiovascular events and cancer, obesity is a worldwide problem affecting developed and developing countries. Microcirculatory vessels, represented by arterioles, capillaries and venules (mean internal diameter < 100 µm), are the place where blood/tissue nutrition and exchange effectively take place. Microvascular dysfunction is an early event in obesity probably secondary to endothelial dysfunction and capillaries rarefaction. New research techniques allow the investigation of the microcirculation in different vascular beds in humans. Studies suggest a link between endothelial dysfunction and visceral obesity. Oxidative stress, inflammation and rennin-angiotensin system are among factors considered to be involved on microvascular dysfunction in obesity. Microcirculatory impairment present in obesity suggests that it could be an important causal factor in obesity-related disorders such as insulin resistance and hypertension.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302009000200015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia &amp; Metabologia v.53 n.2 2009
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
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reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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