Metabolic disturbances linked to obesity: the role of impaired tissue perfusion
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200015 |
Resumo: | Associated with elevated risk of cardiovascular events and cancer, obesity is a worldwide problem affecting developed and developing countries. Microcirculatory vessels, represented by arterioles, capillaries and venules (mean internal diameter < 100 µm), are the place where blood/tissue nutrition and exchange effectively take place. Microvascular dysfunction is an early event in obesity probably secondary to endothelial dysfunction and capillaries rarefaction. New research techniques allow the investigation of the microcirculation in different vascular beds in humans. Studies suggest a link between endothelial dysfunction and visceral obesity. Oxidative stress, inflammation and rennin-angiotensin system are among factors considered to be involved on microvascular dysfunction in obesity. Microcirculatory impairment present in obesity suggests that it could be an important causal factor in obesity-related disorders such as insulin resistance and hypertension. |
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Metabolic disturbances linked to obesity: the role of impaired tissue perfusionObesityendothelial dysfunctionmicrocirculationtissue perfusionmetabolic syndromeAssociated with elevated risk of cardiovascular events and cancer, obesity is a worldwide problem affecting developed and developing countries. Microcirculatory vessels, represented by arterioles, capillaries and venules (mean internal diameter < 100 µm), are the place where blood/tissue nutrition and exchange effectively take place. Microvascular dysfunction is an early event in obesity probably secondary to endothelial dysfunction and capillaries rarefaction. New research techniques allow the investigation of the microcirculation in different vascular beds in humans. Studies suggest a link between endothelial dysfunction and visceral obesity. Oxidative stress, inflammation and rennin-angiotensin system are among factors considered to be involved on microvascular dysfunction in obesity. Microcirculatory impairment present in obesity suggests that it could be an important causal factor in obesity-related disorders such as insulin resistance and hypertension.Sociedade Brasileira de Endocrinologia e Metabologia2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200015Arquivos Brasileiros de Endocrinologia & Metabologia v.53 n.2 2009reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302009000200015info:eu-repo/semantics/openAccessVillela,Nivaldo RibeiroKramer-Aguiar,Luiz GuilhermeBottino,Daniel AlexandreWiernsperger,NicolasBouskela,Elieteeng2015-07-02T00:00:00Zoai:scielo:S0004-27302009000200015Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2015-07-02T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Metabolic disturbances linked to obesity: the role of impaired tissue perfusion |
title |
Metabolic disturbances linked to obesity: the role of impaired tissue perfusion |
spellingShingle |
Metabolic disturbances linked to obesity: the role of impaired tissue perfusion Villela,Nivaldo Ribeiro Obesity endothelial dysfunction microcirculation tissue perfusion metabolic syndrome |
title_short |
Metabolic disturbances linked to obesity: the role of impaired tissue perfusion |
title_full |
Metabolic disturbances linked to obesity: the role of impaired tissue perfusion |
title_fullStr |
Metabolic disturbances linked to obesity: the role of impaired tissue perfusion |
title_full_unstemmed |
Metabolic disturbances linked to obesity: the role of impaired tissue perfusion |
title_sort |
Metabolic disturbances linked to obesity: the role of impaired tissue perfusion |
author |
Villela,Nivaldo Ribeiro |
author_facet |
Villela,Nivaldo Ribeiro Kramer-Aguiar,Luiz Guilherme Bottino,Daniel Alexandre Wiernsperger,Nicolas Bouskela,Eliete |
author_role |
author |
author2 |
Kramer-Aguiar,Luiz Guilherme Bottino,Daniel Alexandre Wiernsperger,Nicolas Bouskela,Eliete |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Villela,Nivaldo Ribeiro Kramer-Aguiar,Luiz Guilherme Bottino,Daniel Alexandre Wiernsperger,Nicolas Bouskela,Eliete |
dc.subject.por.fl_str_mv |
Obesity endothelial dysfunction microcirculation tissue perfusion metabolic syndrome |
topic |
Obesity endothelial dysfunction microcirculation tissue perfusion metabolic syndrome |
description |
Associated with elevated risk of cardiovascular events and cancer, obesity is a worldwide problem affecting developed and developing countries. Microcirculatory vessels, represented by arterioles, capillaries and venules (mean internal diameter < 100 µm), are the place where blood/tissue nutrition and exchange effectively take place. Microvascular dysfunction is an early event in obesity probably secondary to endothelial dysfunction and capillaries rarefaction. New research techniques allow the investigation of the microcirculation in different vascular beds in humans. Studies suggest a link between endothelial dysfunction and visceral obesity. Oxidative stress, inflammation and rennin-angiotensin system are among factors considered to be involved on microvascular dysfunction in obesity. Microcirculatory impairment present in obesity suggests that it could be an important causal factor in obesity-related disorders such as insulin resistance and hypertension. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27302009000200015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia v.53 n.2 2009 reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
collection |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||abem-editoria@endocrino.org.br |
_version_ |
1754734810231734272 |