Molecular genetics of papillary thyroid carcinoma: great expectations...

Detalhes bibliográficos
Autor(a) principal: Trovisco,Vítor
Data de Publicação: 2007
Outros Autores: Soares,Paula, Preto,Ana, Castro,Patrícia, Máximo,Valdemar, Sobrinho-Simões,Manuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000500002
Resumo: Papillary thyroid carcinoma (PTC) is the most prevalent type of endocrine cancer and, in recent epidemiological surveys, one of the types of human cancer whose incidence is growing. Despite the favourable outcome and long survival rates of most patients, some tumours display an aggressive behaviour and may progress to the highly aggressive and lethal, anaplastic thyroid carcinoma. In recent years, several progresses have been made on the molecular characterization of PTC, in general, and in the genetic alterations underlying the histotype diversity of this type of cancer, in particular. This holds true regarding alterations on nuclear DNA as well as mitochondrial DNA. In this review we have summarized the most recent findings in the genetic characterization of PTC, giving a particular emphasis to the genotype-phenotype associations, the prognosis implications, and the diagnostic and therapeutic value of the newly identified genetic markers.
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spelling Molecular genetics of papillary thyroid carcinoma: great expectations...ThyroidPapillary thyroid carcinomaOncogenePapillary thyroid carcinoma (PTC) is the most prevalent type of endocrine cancer and, in recent epidemiological surveys, one of the types of human cancer whose incidence is growing. Despite the favourable outcome and long survival rates of most patients, some tumours display an aggressive behaviour and may progress to the highly aggressive and lethal, anaplastic thyroid carcinoma. In recent years, several progresses have been made on the molecular characterization of PTC, in general, and in the genetic alterations underlying the histotype diversity of this type of cancer, in particular. This holds true regarding alterations on nuclear DNA as well as mitochondrial DNA. In this review we have summarized the most recent findings in the genetic characterization of PTC, giving a particular emphasis to the genotype-phenotype associations, the prognosis implications, and the diagnostic and therapeutic value of the newly identified genetic markers.Sociedade Brasileira de Endocrinologia e Metabologia2007-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000500002Arquivos Brasileiros de Endocrinologia & Metabologia v.51 n.5 2007reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302007000500002info:eu-repo/semantics/openAccessTrovisco,VítorSoares,PaulaPreto,AnaCastro,PatríciaMáximo,ValdemarSobrinho-Simões,Manueleng2007-09-20T00:00:00Zoai:scielo:S0004-27302007000500002Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2007-09-20T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Molecular genetics of papillary thyroid carcinoma: great expectations...
title Molecular genetics of papillary thyroid carcinoma: great expectations...
spellingShingle Molecular genetics of papillary thyroid carcinoma: great expectations...
Trovisco,Vítor
Thyroid
Papillary thyroid carcinoma
Oncogene
title_short Molecular genetics of papillary thyroid carcinoma: great expectations...
title_full Molecular genetics of papillary thyroid carcinoma: great expectations...
title_fullStr Molecular genetics of papillary thyroid carcinoma: great expectations...
title_full_unstemmed Molecular genetics of papillary thyroid carcinoma: great expectations...
title_sort Molecular genetics of papillary thyroid carcinoma: great expectations...
author Trovisco,Vítor
author_facet Trovisco,Vítor
Soares,Paula
Preto,Ana
Castro,Patrícia
Máximo,Valdemar
Sobrinho-Simões,Manuel
author_role author
author2 Soares,Paula
Preto,Ana
Castro,Patrícia
Máximo,Valdemar
Sobrinho-Simões,Manuel
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Trovisco,Vítor
Soares,Paula
Preto,Ana
Castro,Patrícia
Máximo,Valdemar
Sobrinho-Simões,Manuel
dc.subject.por.fl_str_mv Thyroid
Papillary thyroid carcinoma
Oncogene
topic Thyroid
Papillary thyroid carcinoma
Oncogene
description Papillary thyroid carcinoma (PTC) is the most prevalent type of endocrine cancer and, in recent epidemiological surveys, one of the types of human cancer whose incidence is growing. Despite the favourable outcome and long survival rates of most patients, some tumours display an aggressive behaviour and may progress to the highly aggressive and lethal, anaplastic thyroid carcinoma. In recent years, several progresses have been made on the molecular characterization of PTC, in general, and in the genetic alterations underlying the histotype diversity of this type of cancer, in particular. This holds true regarding alterations on nuclear DNA as well as mitochondrial DNA. In this review we have summarized the most recent findings in the genetic characterization of PTC, giving a particular emphasis to the genotype-phenotype associations, the prognosis implications, and the diagnostic and therapeutic value of the newly identified genetic markers.
publishDate 2007
dc.date.none.fl_str_mv 2007-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000500002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302007000500002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302007000500002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.51 n.5 2007
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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