Genetics of diabetic nephropathy

Detalhes bibliográficos
Autor(a) principal: Carpena,Mariana P.
Data de Publicação: 2010
Outros Autores: Rados,Dimitris V., Sortica,Denise A., Souza,Bianca M. de, Reis,André Fernandes, Canani,Luis Henrique, Crispim,Daisy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000300002
Resumo: The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well.
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spelling Genetics of diabetic nephropathyNephropathydiabetes mellitusgeneticsgenetic predispositionThe increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well.Sociedade Brasileira de Endocrinologia e Metabologia2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000300002Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.3 2010reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302010000300002info:eu-repo/semantics/openAccessCarpena,Mariana P.Rados,Dimitris V.Sortica,Denise A.Souza,Bianca M. deReis,André FernandesCanani,Luis HenriqueCrispim,Daisyeng2010-05-26T00:00:00Zoai:scielo:S0004-27302010000300002Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2010-05-26T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Genetics of diabetic nephropathy
title Genetics of diabetic nephropathy
spellingShingle Genetics of diabetic nephropathy
Carpena,Mariana P.
Nephropathy
diabetes mellitus
genetics
genetic predisposition
title_short Genetics of diabetic nephropathy
title_full Genetics of diabetic nephropathy
title_fullStr Genetics of diabetic nephropathy
title_full_unstemmed Genetics of diabetic nephropathy
title_sort Genetics of diabetic nephropathy
author Carpena,Mariana P.
author_facet Carpena,Mariana P.
Rados,Dimitris V.
Sortica,Denise A.
Souza,Bianca M. de
Reis,André Fernandes
Canani,Luis Henrique
Crispim,Daisy
author_role author
author2 Rados,Dimitris V.
Sortica,Denise A.
Souza,Bianca M. de
Reis,André Fernandes
Canani,Luis Henrique
Crispim,Daisy
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Carpena,Mariana P.
Rados,Dimitris V.
Sortica,Denise A.
Souza,Bianca M. de
Reis,André Fernandes
Canani,Luis Henrique
Crispim,Daisy
dc.subject.por.fl_str_mv Nephropathy
diabetes mellitus
genetics
genetic predisposition
topic Nephropathy
diabetes mellitus
genetics
genetic predisposition
description The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000300002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000300002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302010000300002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.3 2010
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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