ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700003 |
Resumo: | Plasma adiponectin and the coding gene for adiponectin, ADIPOQ, are thought to explain part of the interaction between obesity, insulin resistance, type 2 diabetes (T2DM) and coronary artery disease (CAD). Here, we illustrate the role that adiponectin and ADIPOQ variants might play in the modulation of CAD, especially in the occurrence of hyperglycemia. Recent evidence suggests that total and high molecular weight (HMW) adiponectin levels are apparent markers of better cardiovascular prognosis in patients with low risk of CAD. However, in subjects with established or high risk of CAD, these levels are associated with poorer prognosis. We also provide recent evidences relating to the genetic control of total and HMW adiponectin levels, especially evidence regarding ADIPOQ. Accumulated data suggest that both adiponectin levels and polymorphisms in the ADIPOQ gene are linked to the risk of CAD in patients with hyperglycemia, and that these associations seem to be independent from each other, even if adiponectin levels are partly dependent on ADIPOQ. |
id |
SBEM-2_11a378ab1686f2a3e2304fc693d761e3 |
---|---|
oai_identifier_str |
oai:scielo:S0004-27302011000700003 |
network_acronym_str |
SBEM-2 |
network_name_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository_id_str |
|
spelling |
ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease?Total adiponectinHMW adiponectinADIPOQpolymorphismscoronary artery diseasetype 2 diabetes mellitusPlasma adiponectin and the coding gene for adiponectin, ADIPOQ, are thought to explain part of the interaction between obesity, insulin resistance, type 2 diabetes (T2DM) and coronary artery disease (CAD). Here, we illustrate the role that adiponectin and ADIPOQ variants might play in the modulation of CAD, especially in the occurrence of hyperglycemia. Recent evidence suggests that total and high molecular weight (HMW) adiponectin levels are apparent markers of better cardiovascular prognosis in patients with low risk of CAD. However, in subjects with established or high risk of CAD, these levels are associated with poorer prognosis. We also provide recent evidences relating to the genetic control of total and HMW adiponectin levels, especially evidence regarding ADIPOQ. Accumulated data suggest that both adiponectin levels and polymorphisms in the ADIPOQ gene are linked to the risk of CAD in patients with hyperglycemia, and that these associations seem to be independent from each other, even if adiponectin levels are partly dependent on ADIPOQ.Sociedade Brasileira de Endocrinologia e Metabologia2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700003Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.7 2011reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302011000700003info:eu-repo/semantics/openAccessOliveira,Carolina S. V.Giuffrida,Fernando M. A.Crispim,FelipeSaddi-Rosa,PedroReis,André Fernandeseng2011-11-28T00:00:00Zoai:scielo:S0004-27302011000700003Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2011-11-28T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? |
title |
ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? |
spellingShingle |
ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? Oliveira,Carolina S. V. Total adiponectin HMW adiponectin ADIPOQ polymorphisms coronary artery disease type 2 diabetes mellitus |
title_short |
ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? |
title_full |
ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? |
title_fullStr |
ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? |
title_full_unstemmed |
ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? |
title_sort |
ADIPOQ and adiponectin: the common ground of hyperglycemia and coronary artery disease? |
author |
Oliveira,Carolina S. V. |
author_facet |
Oliveira,Carolina S. V. Giuffrida,Fernando M. A. Crispim,Felipe Saddi-Rosa,Pedro Reis,André Fernandes |
author_role |
author |
author2 |
Giuffrida,Fernando M. A. Crispim,Felipe Saddi-Rosa,Pedro Reis,André Fernandes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Oliveira,Carolina S. V. Giuffrida,Fernando M. A. Crispim,Felipe Saddi-Rosa,Pedro Reis,André Fernandes |
dc.subject.por.fl_str_mv |
Total adiponectin HMW adiponectin ADIPOQ polymorphisms coronary artery disease type 2 diabetes mellitus |
topic |
Total adiponectin HMW adiponectin ADIPOQ polymorphisms coronary artery disease type 2 diabetes mellitus |
description |
Plasma adiponectin and the coding gene for adiponectin, ADIPOQ, are thought to explain part of the interaction between obesity, insulin resistance, type 2 diabetes (T2DM) and coronary artery disease (CAD). Here, we illustrate the role that adiponectin and ADIPOQ variants might play in the modulation of CAD, especially in the occurrence of hyperglycemia. Recent evidence suggests that total and high molecular weight (HMW) adiponectin levels are apparent markers of better cardiovascular prognosis in patients with low risk of CAD. However, in subjects with established or high risk of CAD, these levels are associated with poorer prognosis. We also provide recent evidences relating to the genetic control of total and HMW adiponectin levels, especially evidence regarding ADIPOQ. Accumulated data suggest that both adiponectin levels and polymorphisms in the ADIPOQ gene are linked to the risk of CAD in patients with hyperglycemia, and that these associations seem to be independent from each other, even if adiponectin levels are partly dependent on ADIPOQ. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27302011000700003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.7 2011 reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
collection |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||abem-editoria@endocrino.org.br |
_version_ |
1754734811435499520 |