Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study

Detalhes bibliográficos
Autor(a) principal: Bornschein,Andressa
Data de Publicação: 2012
Outros Autores: Paz-Filho,Gilberto, Graf,Hans, Carvalho,Gisah A. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400006
Resumo: OBJECTIVE: Compliance to levothyroxine treatment in hypothyroidism is compromised by daily schedule, and a weekly dose may be an alternative. SUBJECTS AND METHODS: This was a randomized, crossover study. Fourteen females were assigned to daily or weekly doses of LT4. After six weeks, they switched regimens. Thyroid parameters were measured at baseline, and after 42 and 84 days. Echocardiogram and hyperthyroidism symptoms were evaluated before and four hours after LT4 intake. RESULTS: In the weekly dose treatment, fT4 levels were higher after taking LT4, and lower seven days after the last dose; by the 6th week there was a small decrease in T3 levels. TSH remained unchanged and there were no hyperthyroidism symptoms or echocardiographic manifestations. CONCLUSION: Weekly dose leads to transient increases in fT4, without hyperthyroidism or cardiac symptoms. That approach seems to be a safe alternative for the treatment of hypothyroidism.
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spelling Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover studyAdhesiondosingthyroidtreatmentOBJECTIVE: Compliance to levothyroxine treatment in hypothyroidism is compromised by daily schedule, and a weekly dose may be an alternative. SUBJECTS AND METHODS: This was a randomized, crossover study. Fourteen females were assigned to daily or weekly doses of LT4. After six weeks, they switched regimens. Thyroid parameters were measured at baseline, and after 42 and 84 days. Echocardiogram and hyperthyroidism symptoms were evaluated before and four hours after LT4 intake. RESULTS: In the weekly dose treatment, fT4 levels were higher after taking LT4, and lower seven days after the last dose; by the 6th week there was a small decrease in T3 levels. TSH remained unchanged and there were no hyperthyroidism symptoms or echocardiographic manifestations. CONCLUSION: Weekly dose leads to transient increases in fT4, without hyperthyroidism or cardiac symptoms. That approach seems to be a safe alternative for the treatment of hypothyroidism.Sociedade Brasileira de Endocrinologia e Metabologia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400006Arquivos Brasileiros de Endocrinologia & Metabologia v.56 n.4 2012reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302012000400006info:eu-repo/semantics/openAccessBornschein,AndressaPaz-Filho,GilbertoGraf,HansCarvalho,Gisah A. deeng2012-07-11T00:00:00Zoai:scielo:S0004-27302012000400006Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2012-07-11T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study
title Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study
spellingShingle Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study
Bornschein,Andressa
Adhesion
dosing
thyroid
treatment
title_short Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study
title_full Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study
title_fullStr Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study
title_full_unstemmed Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study
title_sort Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study
author Bornschein,Andressa
author_facet Bornschein,Andressa
Paz-Filho,Gilberto
Graf,Hans
Carvalho,Gisah A. de
author_role author
author2 Paz-Filho,Gilberto
Graf,Hans
Carvalho,Gisah A. de
author2_role author
author
author
dc.contributor.author.fl_str_mv Bornschein,Andressa
Paz-Filho,Gilberto
Graf,Hans
Carvalho,Gisah A. de
dc.subject.por.fl_str_mv Adhesion
dosing
thyroid
treatment
topic Adhesion
dosing
thyroid
treatment
description OBJECTIVE: Compliance to levothyroxine treatment in hypothyroidism is compromised by daily schedule, and a weekly dose may be an alternative. SUBJECTS AND METHODS: This was a randomized, crossover study. Fourteen females were assigned to daily or weekly doses of LT4. After six weeks, they switched regimens. Thyroid parameters were measured at baseline, and after 42 and 84 days. Echocardiogram and hyperthyroidism symptoms were evaluated before and four hours after LT4 intake. RESULTS: In the weekly dose treatment, fT4 levels were higher after taking LT4, and lower seven days after the last dose; by the 6th week there was a small decrease in T3 levels. TSH remained unchanged and there were no hyperthyroidism symptoms or echocardiographic manifestations. CONCLUSION: Weekly dose leads to transient increases in fT4, without hyperthyroidism or cardiac symptoms. That approach seems to be a safe alternative for the treatment of hypothyroidism.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302012000400006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.56 n.4 2012
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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