The natural history of type 1A diabetes

Detalhes bibliográficos
Autor(a) principal: Eisenbarth,George S.
Data de Publicação: 2008
Outros Autores: Jeffrey,Joy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000200002
Resumo: We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a major goal is the prevention of type 1A diabetes in man with multiple clinical trials underway.
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spelling The natural history of type 1A diabetesType 1 diabetesAnti-islet autoimmunityAutoantibodiesHLAGeneticWe can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a major goal is the prevention of type 1A diabetes in man with multiple clinical trials underway.Sociedade Brasileira de Endocrinologia e Metabologia2008-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000200002Arquivos Brasileiros de Endocrinologia & Metabologia v.52 n.2 2008reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302008000200002info:eu-repo/semantics/openAccessEisenbarth,George S.Jeffrey,Joyeng2008-04-25T00:00:00Zoai:scielo:S0004-27302008000200002Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2008-04-25T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv The natural history of type 1A diabetes
title The natural history of type 1A diabetes
spellingShingle The natural history of type 1A diabetes
Eisenbarth,George S.
Type 1 diabetes
Anti-islet autoimmunity
Autoantibodies
HLA
Genetic
title_short The natural history of type 1A diabetes
title_full The natural history of type 1A diabetes
title_fullStr The natural history of type 1A diabetes
title_full_unstemmed The natural history of type 1A diabetes
title_sort The natural history of type 1A diabetes
author Eisenbarth,George S.
author_facet Eisenbarth,George S.
Jeffrey,Joy
author_role author
author2 Jeffrey,Joy
author2_role author
dc.contributor.author.fl_str_mv Eisenbarth,George S.
Jeffrey,Joy
dc.subject.por.fl_str_mv Type 1 diabetes
Anti-islet autoimmunity
Autoantibodies
HLA
Genetic
topic Type 1 diabetes
Anti-islet autoimmunity
Autoantibodies
HLA
Genetic
description We can now predict the development of Type 1A (Immune Mediated) diabetes primarily through the determination of four biochemically characterized islet autoantibodies [insulin, GAD65, IA-2 (ICA512) and (Znt8)]. Prediction is possible because beta-cell destruction is chronically progressive and very slow in most, but not all individuals. We can also prevent type 1A diabetes in animal models and a major goal is the prevention of type 1A diabetes in man with multiple clinical trials underway.
publishDate 2008
dc.date.none.fl_str_mv 2008-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000200002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000200002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302008000200002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.52 n.2 2008
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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