Diabetic nephropathy in type 2 diabetes mellitus: risk factors and prevention

Detalhes bibliográficos
Autor(a) principal: Murussi,Marcia
Data de Publicação: 2003
Outros Autores: Coester,Ariane, Gross,Jorge Luiz, Silveiro,Sandra Pinho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302003000300003
Resumo: Diabetic nephropathy (DN) is responsible for the increasing number of patients on dialysis in developing countries, and is already the most common cause of renal replacement therapy in the developed ones. In this manuscript, we review the risk factors and point out strategies to prevent this microvascular complication in type 2 diabetic patients (DM2). There are some known genetic and non-genetic risk factors related to the development and progression of DN in DM2 patients. Candidate genes have been analysed, but there are still controversy about the genetic markers of the disease. Recognized non-genetic risk factors are poor glycemic, pressoric and lipidic control. Additionally, it has been suggested that the presence of diabetic retinopathy, autonomic neuropathy, smoking habit, higher protein ingestion, and higher normal levels of albuminuria (even within the normal range) are associated with an increased risk of developing DN. Some strategies have been investigated and proved to prevent or at least to postpone DN, such as to control blood pressure, glycemic levels and dyslipidemia. Furthermore, angiotensin-converting enzyme inhibitors and angiotensin-II blockers have independent effects, not explained by blood pressure control alone. Other therapeutic items are to consume a low protein diet and to quit smoking.
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spelling Diabetic nephropathy in type 2 diabetes mellitus: risk factors and preventionRisk factorsDiabetic nephropathyType 2 diabetes mellitusPreventionDiabetic nephropathy (DN) is responsible for the increasing number of patients on dialysis in developing countries, and is already the most common cause of renal replacement therapy in the developed ones. In this manuscript, we review the risk factors and point out strategies to prevent this microvascular complication in type 2 diabetic patients (DM2). There are some known genetic and non-genetic risk factors related to the development and progression of DN in DM2 patients. Candidate genes have been analysed, but there are still controversy about the genetic markers of the disease. Recognized non-genetic risk factors are poor glycemic, pressoric and lipidic control. Additionally, it has been suggested that the presence of diabetic retinopathy, autonomic neuropathy, smoking habit, higher protein ingestion, and higher normal levels of albuminuria (even within the normal range) are associated with an increased risk of developing DN. Some strategies have been investigated and proved to prevent or at least to postpone DN, such as to control blood pressure, glycemic levels and dyslipidemia. Furthermore, angiotensin-converting enzyme inhibitors and angiotensin-II blockers have independent effects, not explained by blood pressure control alone. Other therapeutic items are to consume a low protein diet and to quit smoking.Sociedade Brasileira de Endocrinologia e Metabologia2003-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302003000300003Arquivos Brasileiros de Endocrinologia & Metabologia v.47 n.3 2003reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302003000300003info:eu-repo/semantics/openAccessMurussi,MarciaCoester,ArianeGross,Jorge LuizSilveiro,Sandra Pinhoeng2003-08-01T00:00:00Zoai:scielo:S0004-27302003000300003Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2003-08-01T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Diabetic nephropathy in type 2 diabetes mellitus: risk factors and prevention
title Diabetic nephropathy in type 2 diabetes mellitus: risk factors and prevention
spellingShingle Diabetic nephropathy in type 2 diabetes mellitus: risk factors and prevention
Murussi,Marcia
Risk factors
Diabetic nephropathy
Type 2 diabetes mellitus
Prevention
title_short Diabetic nephropathy in type 2 diabetes mellitus: risk factors and prevention
title_full Diabetic nephropathy in type 2 diabetes mellitus: risk factors and prevention
title_fullStr Diabetic nephropathy in type 2 diabetes mellitus: risk factors and prevention
title_full_unstemmed Diabetic nephropathy in type 2 diabetes mellitus: risk factors and prevention
title_sort Diabetic nephropathy in type 2 diabetes mellitus: risk factors and prevention
author Murussi,Marcia
author_facet Murussi,Marcia
Coester,Ariane
Gross,Jorge Luiz
Silveiro,Sandra Pinho
author_role author
author2 Coester,Ariane
Gross,Jorge Luiz
Silveiro,Sandra Pinho
author2_role author
author
author
dc.contributor.author.fl_str_mv Murussi,Marcia
Coester,Ariane
Gross,Jorge Luiz
Silveiro,Sandra Pinho
dc.subject.por.fl_str_mv Risk factors
Diabetic nephropathy
Type 2 diabetes mellitus
Prevention
topic Risk factors
Diabetic nephropathy
Type 2 diabetes mellitus
Prevention
description Diabetic nephropathy (DN) is responsible for the increasing number of patients on dialysis in developing countries, and is already the most common cause of renal replacement therapy in the developed ones. In this manuscript, we review the risk factors and point out strategies to prevent this microvascular complication in type 2 diabetic patients (DM2). There are some known genetic and non-genetic risk factors related to the development and progression of DN in DM2 patients. Candidate genes have been analysed, but there are still controversy about the genetic markers of the disease. Recognized non-genetic risk factors are poor glycemic, pressoric and lipidic control. Additionally, it has been suggested that the presence of diabetic retinopathy, autonomic neuropathy, smoking habit, higher protein ingestion, and higher normal levels of albuminuria (even within the normal range) are associated with an increased risk of developing DN. Some strategies have been investigated and proved to prevent or at least to postpone DN, such as to control blood pressure, glycemic levels and dyslipidemia. Furthermore, angiotensin-converting enzyme inhibitors and angiotensin-II blockers have independent effects, not explained by blood pressure control alone. Other therapeutic items are to consume a low protein diet and to quit smoking.
publishDate 2003
dc.date.none.fl_str_mv 2003-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302003000300003
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302003000300003
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.47 n.3 2003
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
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