The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications

Detalhes bibliográficos
Autor(a) principal: Souza,Bianca Marmontel de
Data de Publicação: 2011
Outros Autores: Assmann,Taís Silveira, Kliemann,Lúcia Maria, Gross,Jorge Luiz, Canani,Luís Henrique, Crispim,Daisy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400001
Resumo: It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus (DM2) and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. Therefore, great efforts have been made to identify genes associated with DM2. Uncoupling protein 2 (UCP2) is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism. All these mechanisms are associated with DM2 pathogenesis and its chronic complications. Therefore, UCP2 is a candidate gene for the development of these disorders. Indeed, several studies have reported that three common polymorphisms in UCP2 gene are possibly associated with DM2 and/or obesity. Only a few studies investigated these polymorphisms in relation to chronic complications of diabetes, with inconclusive results.
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spelling The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complicationsUCP2type 2 diabetes mellitusdiabetic retinopathydiabetic nephropathyDNA polymorphismshaplotypeIt is well established that genetic factors play an important role in the development of type 2 diabetes mellitus (DM2) and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. Therefore, great efforts have been made to identify genes associated with DM2. Uncoupling protein 2 (UCP2) is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism. All these mechanisms are associated with DM2 pathogenesis and its chronic complications. Therefore, UCP2 is a candidate gene for the development of these disorders. Indeed, several studies have reported that three common polymorphisms in UCP2 gene are possibly associated with DM2 and/or obesity. Only a few studies investigated these polymorphisms in relation to chronic complications of diabetes, with inconclusive results.Sociedade Brasileira de Endocrinologia e Metabologia2011-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400001Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.4 2011reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302011000400001info:eu-repo/semantics/openAccessSouza,Bianca Marmontel deAssmann,Taís SilveiraKliemann,Lúcia MariaGross,Jorge LuizCanani,Luís HenriqueCrispim,Daisyeng2011-07-07T00:00:00Zoai:scielo:S0004-27302011000400001Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2011-07-07T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
title The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
spellingShingle The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
Souza,Bianca Marmontel de
UCP2
type 2 diabetes mellitus
diabetic retinopathy
diabetic nephropathy
DNA polymorphisms
haplotype
title_short The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
title_full The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
title_fullStr The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
title_full_unstemmed The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
title_sort The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
author Souza,Bianca Marmontel de
author_facet Souza,Bianca Marmontel de
Assmann,Taís Silveira
Kliemann,Lúcia Maria
Gross,Jorge Luiz
Canani,Luís Henrique
Crispim,Daisy
author_role author
author2 Assmann,Taís Silveira
Kliemann,Lúcia Maria
Gross,Jorge Luiz
Canani,Luís Henrique
Crispim,Daisy
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Souza,Bianca Marmontel de
Assmann,Taís Silveira
Kliemann,Lúcia Maria
Gross,Jorge Luiz
Canani,Luís Henrique
Crispim,Daisy
dc.subject.por.fl_str_mv UCP2
type 2 diabetes mellitus
diabetic retinopathy
diabetic nephropathy
DNA polymorphisms
haplotype
topic UCP2
type 2 diabetes mellitus
diabetic retinopathy
diabetic nephropathy
DNA polymorphisms
haplotype
description It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus (DM2) and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. Therefore, great efforts have been made to identify genes associated with DM2. Uncoupling protein 2 (UCP2) is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism. All these mechanisms are associated with DM2 pathogenesis and its chronic complications. Therefore, UCP2 is a candidate gene for the development of these disorders. Indeed, several studies have reported that three common polymorphisms in UCP2 gene are possibly associated with DM2 and/or obesity. Only a few studies investigated these polymorphisms in relation to chronic complications of diabetes, with inconclusive results.
publishDate 2011
dc.date.none.fl_str_mv 2011-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000400001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302011000400001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.4 2011
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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