Subclinical hypothyroidism and risk to carotid atherosclerosis

Detalhes bibliográficos
Autor(a) principal: Valentina,Velkoska Nakova
Data de Publicação: 2011
Outros Autores: Marijan,Bosevski, Chedo,Dimitrovski, Branka,Krstevska
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700007
Resumo: OBJECTIVE: The aim of this study was to assess whether subclinical hypothyroidism (SCH) is associated with carotid atherosclerosis, as well as dyslipidemia, and arterial hypertension. SUBJECTS AND METHODS: The study included 69 consecutive patients with newly diagnosed SCH, and 30 matched healthy controls. Body mass index (BMI), TSH, fT4, antibodies to thyroid peroxidase (TPOabs), lipids, blood pressure, mean and maximum carotid intima-media thickness (CIMT) were determined in all participants. RESULTS: Mean values of CIMT, triglycerides, and total cholesterol/HDL-C ratio were significantly different in SCH patients versus matched controls. Linear multiple regression analysis demonstrated that TSH, diastolic blood pressure and triglycerides were independent predictors of mean CIMT, fT4 for maximum CIMT; and that TSH, fT4, age, and total cholesterol/HDL-C ratio were independent predictors of the presence of carotid plaques. CONCLUSION: Our data revealed that SCH is associated with increase in CIMT and presence of carotid plaques, independent of classical risk factors for atherosclerosis.
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spelling Subclinical hypothyroidism and risk to carotid atherosclerosisSubclinical hypothyroidismatherosclerosisdyslipidemiaarterial hypertensioncarotid intima-media thicknessOBJECTIVE: The aim of this study was to assess whether subclinical hypothyroidism (SCH) is associated with carotid atherosclerosis, as well as dyslipidemia, and arterial hypertension. SUBJECTS AND METHODS: The study included 69 consecutive patients with newly diagnosed SCH, and 30 matched healthy controls. Body mass index (BMI), TSH, fT4, antibodies to thyroid peroxidase (TPOabs), lipids, blood pressure, mean and maximum carotid intima-media thickness (CIMT) were determined in all participants. RESULTS: Mean values of CIMT, triglycerides, and total cholesterol/HDL-C ratio were significantly different in SCH patients versus matched controls. Linear multiple regression analysis demonstrated that TSH, diastolic blood pressure and triglycerides were independent predictors of mean CIMT, fT4 for maximum CIMT; and that TSH, fT4, age, and total cholesterol/HDL-C ratio were independent predictors of the presence of carotid plaques. CONCLUSION: Our data revealed that SCH is associated with increase in CIMT and presence of carotid plaques, independent of classical risk factors for atherosclerosis.Sociedade Brasileira de Endocrinologia e Metabologia2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700007Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.7 2011reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302011000700007info:eu-repo/semantics/openAccessValentina,Velkoska NakovaMarijan,BosevskiChedo,DimitrovskiBranka,Krstevskaeng2011-11-28T00:00:00Zoai:scielo:S0004-27302011000700007Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2011-11-28T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Subclinical hypothyroidism and risk to carotid atherosclerosis
title Subclinical hypothyroidism and risk to carotid atherosclerosis
spellingShingle Subclinical hypothyroidism and risk to carotid atherosclerosis
Valentina,Velkoska Nakova
Subclinical hypothyroidism
atherosclerosis
dyslipidemia
arterial hypertension
carotid intima-media thickness
title_short Subclinical hypothyroidism and risk to carotid atherosclerosis
title_full Subclinical hypothyroidism and risk to carotid atherosclerosis
title_fullStr Subclinical hypothyroidism and risk to carotid atherosclerosis
title_full_unstemmed Subclinical hypothyroidism and risk to carotid atherosclerosis
title_sort Subclinical hypothyroidism and risk to carotid atherosclerosis
author Valentina,Velkoska Nakova
author_facet Valentina,Velkoska Nakova
Marijan,Bosevski
Chedo,Dimitrovski
Branka,Krstevska
author_role author
author2 Marijan,Bosevski
Chedo,Dimitrovski
Branka,Krstevska
author2_role author
author
author
dc.contributor.author.fl_str_mv Valentina,Velkoska Nakova
Marijan,Bosevski
Chedo,Dimitrovski
Branka,Krstevska
dc.subject.por.fl_str_mv Subclinical hypothyroidism
atherosclerosis
dyslipidemia
arterial hypertension
carotid intima-media thickness
topic Subclinical hypothyroidism
atherosclerosis
dyslipidemia
arterial hypertension
carotid intima-media thickness
description OBJECTIVE: The aim of this study was to assess whether subclinical hypothyroidism (SCH) is associated with carotid atherosclerosis, as well as dyslipidemia, and arterial hypertension. SUBJECTS AND METHODS: The study included 69 consecutive patients with newly diagnosed SCH, and 30 matched healthy controls. Body mass index (BMI), TSH, fT4, antibodies to thyroid peroxidase (TPOabs), lipids, blood pressure, mean and maximum carotid intima-media thickness (CIMT) were determined in all participants. RESULTS: Mean values of CIMT, triglycerides, and total cholesterol/HDL-C ratio were significantly different in SCH patients versus matched controls. Linear multiple regression analysis demonstrated that TSH, diastolic blood pressure and triglycerides were independent predictors of mean CIMT, fT4 for maximum CIMT; and that TSH, fT4, age, and total cholesterol/HDL-C ratio were independent predictors of the presence of carotid plaques. CONCLUSION: Our data revealed that SCH is associated with increase in CIMT and presence of carotid plaques, independent of classical risk factors for atherosclerosis.
publishDate 2011
dc.date.none.fl_str_mv 2011-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302011000700007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.7 2011
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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