Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function

• Autor(a) principal: Martins,Ricardo Mendes
• Data de Publicação: 2011
• Outros Autores: Fonseca,Regina Helena Alves, Duarte,Marta Maria Turano, Reuters,Vaneska Spinelli, Ferreira,Márcia Martins, Almeida,Cloyra, Buescu,Alexandru, Teixeira,Patrícia de Fátima dos Santos, Vaisman,Mario
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000700005
• topic: Hypothyroidism; thyroxine; echocardiography; Doppler; cardiovascular disease

OBJECTIVE: To evaluate the effects of levothyroxine (L-T4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (SH). SUBJECTS AND METHODS: This was a randomized, double-blind, placebo-controlled study. Echocardiographic evaluation was carried out at baseline and one year after restoration of euthyroidism. Thirty-three women with SH were assigned to one of two groups (L-T4 or placebo). RESULTS: The two groups had similar basal characteristics. There was a significant deterioration of left ventricular Tei index after one year of placebo use, which differed from the effect of L-T4 replacement (+0.086 ± 0.092 vs. -0.014 ± 0.012; p = 0.047). There was also a slight reduction in cardiac output and cardiac index with placebo use, which was not different from L-T4 effect. CONCLUSION: Results suggest a positive impact of L-T4 replacement in cardiac function of middle-aged women with SH.