Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000600008 |
Resumo: | OBJECTIVES: To determine the prevalence of insulin resistance (IR) in non-diabetic patients with chronic hepatitis C, and to assess the association between IR, laboratory parameters and histological findings. SUBJECTS AND METHODS: Eighty-two patients had their serum analyzed for glucose, lipid profile, C-reactive protein (CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), HOMA-IR, viral load and HCV genotype. Patients with HOMA-IR levels > 2.5 were considered as carriers of insulin resistance. RESULTS: IR was observed in 27% of patients and was associated with age, waist circumference and body mass index. IR patients were more likely to have more advanced hepatic fibrosis and necroinflammatory activity, higher levels of aminotransferases and liver steatosis than patients without IR. CONCLUSIONS: Insulin resistance is often present in patients with chronic hepatitis C, and this parameter is associated with more advanced HCV-related hepatic fibrosis. |
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Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
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Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?Chronic hepatitis Cliver fibrosisinsulin resistanceHOMA-IROBJECTIVES: To determine the prevalence of insulin resistance (IR) in non-diabetic patients with chronic hepatitis C, and to assess the association between IR, laboratory parameters and histological findings. SUBJECTS AND METHODS: Eighty-two patients had their serum analyzed for glucose, lipid profile, C-reactive protein (CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), HOMA-IR, viral load and HCV genotype. Patients with HOMA-IR levels > 2.5 were considered as carriers of insulin resistance. RESULTS: IR was observed in 27% of patients and was associated with age, waist circumference and body mass index. IR patients were more likely to have more advanced hepatic fibrosis and necroinflammatory activity, higher levels of aminotransferases and liver steatosis than patients without IR. CONCLUSIONS: Insulin resistance is often present in patients with chronic hepatitis C, and this parameter is associated with more advanced HCV-related hepatic fibrosis.Sociedade Brasileira de Endocrinologia e Metabologia2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000600008Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.6 2011reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302011000600008info:eu-repo/semantics/openAccessSouza,Aécio Flávio Meirelles dePace,Fábio Heleno de LimaChebli,Júlio Maria FonsecaFerreira,Lincoln Eduardo Villela Vieira de Castroeng2011-10-07T00:00:00Zoai:scielo:S0004-27302011000600008Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2011-10-07T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean? |
title |
Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean? |
spellingShingle |
Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean? Souza,Aécio Flávio Meirelles de Chronic hepatitis C liver fibrosis insulin resistance HOMA-IR |
title_short |
Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean? |
title_full |
Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean? |
title_fullStr |
Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean? |
title_full_unstemmed |
Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean? |
title_sort |
Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean? |
author |
Souza,Aécio Flávio Meirelles de |
author_facet |
Souza,Aécio Flávio Meirelles de Pace,Fábio Heleno de Lima Chebli,Júlio Maria Fonseca Ferreira,Lincoln Eduardo Villela Vieira de Castro |
author_role |
author |
author2 |
Pace,Fábio Heleno de Lima Chebli,Júlio Maria Fonseca Ferreira,Lincoln Eduardo Villela Vieira de Castro |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Souza,Aécio Flávio Meirelles de Pace,Fábio Heleno de Lima Chebli,Júlio Maria Fonseca Ferreira,Lincoln Eduardo Villela Vieira de Castro |
dc.subject.por.fl_str_mv |
Chronic hepatitis C liver fibrosis insulin resistance HOMA-IR |
topic |
Chronic hepatitis C liver fibrosis insulin resistance HOMA-IR |
description |
OBJECTIVES: To determine the prevalence of insulin resistance (IR) in non-diabetic patients with chronic hepatitis C, and to assess the association between IR, laboratory parameters and histological findings. SUBJECTS AND METHODS: Eighty-two patients had their serum analyzed for glucose, lipid profile, C-reactive protein (CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), HOMA-IR, viral load and HCV genotype. Patients with HOMA-IR levels > 2.5 were considered as carriers of insulin resistance. RESULTS: IR was observed in 27% of patients and was associated with age, waist circumference and body mass index. IR patients were more likely to have more advanced hepatic fibrosis and necroinflammatory activity, higher levels of aminotransferases and liver steatosis than patients without IR. CONCLUSIONS: Insulin resistance is often present in patients with chronic hepatitis C, and this parameter is associated with more advanced HCV-related hepatic fibrosis. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000600008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000600008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27302011000600008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.6 2011 reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
collection |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||abem-editoria@endocrino.org.br |
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1754734811428159488 |