Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?

Detalhes bibliográficos
Autor(a) principal: Souza,Aécio Flávio Meirelles de
Data de Publicação: 2011
Outros Autores: Pace,Fábio Heleno de Lima, Chebli,Júlio Maria Fonseca, Ferreira,Lincoln Eduardo Villela Vieira de Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000600008
Resumo: OBJECTIVES: To determine the prevalence of insulin resistance (IR) in non-diabetic patients with chronic hepatitis C, and to assess the association between IR, laboratory parameters and histological findings. SUBJECTS AND METHODS: Eighty-two patients had their serum analyzed for glucose, lipid profile, C-reactive protein (CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), HOMA-IR, viral load and HCV genotype. Patients with HOMA-IR levels > 2.5 were considered as carriers of insulin resistance. RESULTS: IR was observed in 27% of patients and was associated with age, waist circumference and body mass index. IR patients were more likely to have more advanced hepatic fibrosis and necroinflammatory activity, higher levels of aminotransferases and liver steatosis than patients without IR. CONCLUSIONS: Insulin resistance is often present in patients with chronic hepatitis C, and this parameter is associated with more advanced HCV-related hepatic fibrosis.
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spelling Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?Chronic hepatitis Cliver fibrosisinsulin resistanceHOMA-IROBJECTIVES: To determine the prevalence of insulin resistance (IR) in non-diabetic patients with chronic hepatitis C, and to assess the association between IR, laboratory parameters and histological findings. SUBJECTS AND METHODS: Eighty-two patients had their serum analyzed for glucose, lipid profile, C-reactive protein (CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), HOMA-IR, viral load and HCV genotype. Patients with HOMA-IR levels > 2.5 were considered as carriers of insulin resistance. RESULTS: IR was observed in 27% of patients and was associated with age, waist circumference and body mass index. IR patients were more likely to have more advanced hepatic fibrosis and necroinflammatory activity, higher levels of aminotransferases and liver steatosis than patients without IR. CONCLUSIONS: Insulin resistance is often present in patients with chronic hepatitis C, and this parameter is associated with more advanced HCV-related hepatic fibrosis.Sociedade Brasileira de Endocrinologia e Metabologia2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000600008Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.6 2011reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302011000600008info:eu-repo/semantics/openAccessSouza,Aécio Flávio Meirelles dePace,Fábio Heleno de LimaChebli,Júlio Maria FonsecaFerreira,Lincoln Eduardo Villela Vieira de Castroeng2011-10-07T00:00:00Zoai:scielo:S0004-27302011000600008Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2011-10-07T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
title Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
spellingShingle Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
Souza,Aécio Flávio Meirelles de
Chronic hepatitis C
liver fibrosis
insulin resistance
HOMA-IR
title_short Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
title_full Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
title_fullStr Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
title_full_unstemmed Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
title_sort Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?
author Souza,Aécio Flávio Meirelles de
author_facet Souza,Aécio Flávio Meirelles de
Pace,Fábio Heleno de Lima
Chebli,Júlio Maria Fonseca
Ferreira,Lincoln Eduardo Villela Vieira de Castro
author_role author
author2 Pace,Fábio Heleno de Lima
Chebli,Júlio Maria Fonseca
Ferreira,Lincoln Eduardo Villela Vieira de Castro
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza,Aécio Flávio Meirelles de
Pace,Fábio Heleno de Lima
Chebli,Júlio Maria Fonseca
Ferreira,Lincoln Eduardo Villela Vieira de Castro
dc.subject.por.fl_str_mv Chronic hepatitis C
liver fibrosis
insulin resistance
HOMA-IR
topic Chronic hepatitis C
liver fibrosis
insulin resistance
HOMA-IR
description OBJECTIVES: To determine the prevalence of insulin resistance (IR) in non-diabetic patients with chronic hepatitis C, and to assess the association between IR, laboratory parameters and histological findings. SUBJECTS AND METHODS: Eighty-two patients had their serum analyzed for glucose, lipid profile, C-reactive protein (CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), HOMA-IR, viral load and HCV genotype. Patients with HOMA-IR levels > 2.5 were considered as carriers of insulin resistance. RESULTS: IR was observed in 27% of patients and was associated with age, waist circumference and body mass index. IR patients were more likely to have more advanced hepatic fibrosis and necroinflammatory activity, higher levels of aminotransferases and liver steatosis than patients without IR. CONCLUSIONS: Insulin resistance is often present in patients with chronic hepatitis C, and this parameter is associated with more advanced HCV-related hepatic fibrosis.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000600008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000600008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302011000600008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.55 n.6 2011
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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