Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal woman
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000700016 |
Resumo: | Adrenal incidentaloma is not infrequent and can be found in hirsute women. We report a case of a 54-year-old woman with amenorrhea and hirsutism of abrupt onset and mild signs of virilization that had an adrenal incidentaloma coexisting with ovarian hyperthecosis. Basal total and free testosterone were 191 ng/dL and 179 pmol/L. Pelvic ultrasonography disclosed a right ovary with 10.3 cc and a left ovary with 9.8 cc without nodules or cysts, and computerized tomography of the abdomen disclosed a normal right adrenal gland. On the left adrenal gland a solid nodule with 0.8 cm was seen. After GnRHa administration, total testosterone was 23 ng/dL and free testosterone was 17 pmol/L. In view of a suppression of testosterone by GnRHa, the patient was submitted to a hystero-oophorectomy by laparoscopy. Symmetrically enlarged ovaries were seen. No tumor was apparent. Histology showed hyperthecosis, with foci of luteinized stromal cells. Only atretic follicles were detected. No hilar cell hyperplasia was seen. In conclusion, the presence of an adrenal mass in a hirsute woman can lead to a wrong diagnosis. In this case the suppression GnRHa test was fundamental to determine the origin of hyperandrogenemia. |
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Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal womanHirsutismOvarian hyperthecosisAdrenal incidentalomaMenopauseAdrenal incidentaloma is not infrequent and can be found in hirsute women. We report a case of a 54-year-old woman with amenorrhea and hirsutism of abrupt onset and mild signs of virilization that had an adrenal incidentaloma coexisting with ovarian hyperthecosis. Basal total and free testosterone were 191 ng/dL and 179 pmol/L. Pelvic ultrasonography disclosed a right ovary with 10.3 cc and a left ovary with 9.8 cc without nodules or cysts, and computerized tomography of the abdomen disclosed a normal right adrenal gland. On the left adrenal gland a solid nodule with 0.8 cm was seen. After GnRHa administration, total testosterone was 23 ng/dL and free testosterone was 17 pmol/L. In view of a suppression of testosterone by GnRHa, the patient was submitted to a hystero-oophorectomy by laparoscopy. Symmetrically enlarged ovaries were seen. No tumor was apparent. Histology showed hyperthecosis, with foci of luteinized stromal cells. Only atretic follicles were detected. No hilar cell hyperplasia was seen. In conclusion, the presence of an adrenal mass in a hirsute woman can lead to a wrong diagnosis. In this case the suppression GnRHa test was fundamental to determine the origin of hyperandrogenemia.Sociedade Brasileira de Endocrinologia e Metabologia2008-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000700016Arquivos Brasileiros de Endocrinologia & Metabologia v.52 n.7 2008reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302008000700016info:eu-repo/semantics/openAccessMarcondes,José A. M.Curi,Daniela D. G.Matsuzaki,Cezar N.Barcellos,Cristiano R. G.Rocha,Michelle P.Hayashida,Sylvia A. Y.Baracat,Edmund C.eng2008-12-03T00:00:00Zoai:scielo:S0004-27302008000700016Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2008-12-03T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal woman |
title |
Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal woman |
spellingShingle |
Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal woman Marcondes,José A. M. Hirsutism Ovarian hyperthecosis Adrenal incidentaloma Menopause |
title_short |
Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal woman |
title_full |
Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal woman |
title_fullStr |
Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal woman |
title_full_unstemmed |
Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal woman |
title_sort |
Ovarian hyperthecosis in the context of an adrenal incidentaloma in a postmenopausal woman |
author |
Marcondes,José A. M. |
author_facet |
Marcondes,José A. M. Curi,Daniela D. G. Matsuzaki,Cezar N. Barcellos,Cristiano R. G. Rocha,Michelle P. Hayashida,Sylvia A. Y. Baracat,Edmund C. |
author_role |
author |
author2 |
Curi,Daniela D. G. Matsuzaki,Cezar N. Barcellos,Cristiano R. G. Rocha,Michelle P. Hayashida,Sylvia A. Y. Baracat,Edmund C. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Marcondes,José A. M. Curi,Daniela D. G. Matsuzaki,Cezar N. Barcellos,Cristiano R. G. Rocha,Michelle P. Hayashida,Sylvia A. Y. Baracat,Edmund C. |
dc.subject.por.fl_str_mv |
Hirsutism Ovarian hyperthecosis Adrenal incidentaloma Menopause |
topic |
Hirsutism Ovarian hyperthecosis Adrenal incidentaloma Menopause |
description |
Adrenal incidentaloma is not infrequent and can be found in hirsute women. We report a case of a 54-year-old woman with amenorrhea and hirsutism of abrupt onset and mild signs of virilization that had an adrenal incidentaloma coexisting with ovarian hyperthecosis. Basal total and free testosterone were 191 ng/dL and 179 pmol/L. Pelvic ultrasonography disclosed a right ovary with 10.3 cc and a left ovary with 9.8 cc without nodules or cysts, and computerized tomography of the abdomen disclosed a normal right adrenal gland. On the left adrenal gland a solid nodule with 0.8 cm was seen. After GnRHa administration, total testosterone was 23 ng/dL and free testosterone was 17 pmol/L. In view of a suppression of testosterone by GnRHa, the patient was submitted to a hystero-oophorectomy by laparoscopy. Symmetrically enlarged ovaries were seen. No tumor was apparent. Histology showed hyperthecosis, with foci of luteinized stromal cells. Only atretic follicles were detected. No hilar cell hyperplasia was seen. In conclusion, the presence of an adrenal mass in a hirsute woman can lead to a wrong diagnosis. In this case the suppression GnRHa test was fundamental to determine the origin of hyperandrogenemia. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000700016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000700016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27302008000700016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia v.52 n.7 2008 reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
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SBEM |
institution |
SBEM |
reponame_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
collection |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||abem-editoria@endocrino.org.br |
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1754734810098565120 |