Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review

Detalhes bibliográficos
Autor(a) principal: Magnata Filho,Luiz Antônio
Data de Publicação: 2010
Outros Autores: Bordallo,Maria Alice Neves, Pessoa,Cencita H. C. N., Corbo,Rossana, Bulzico,Daniel Alves, Dias,Fernando Luiz, Machado,Avelino L., Soares,Andréia B., Ferman,Sima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000700011
Resumo: Spindle epithelial tumor with thymus-like element (SETTLE) is a rare malignant neoplasm of the thyroid, occurring predominantly in children, adolescents, and young adults. SETTLE usually presents itself as a thyroid mass, without metastases at diagnosis. It is believed to derive from branchial pouch or thymic remnant tissue showing primitive thymic differentiation. This article reports the clinical, cytological, histological and immunohistochemical features of a SETTLE in a 3-year-old girl. Microscopic exam revealed a nodular, highly cellular neoplasm displayed in the classic biphasic pattern, with mixture of prominent spindle cell component and a minor glandular component lined by mucinous or respiratory-type epithelium. The immunohistochemical study showed strong and diffuse positivity for pan-CK, vimentin and smooth muscle actin. The present case is the first SETTLE case reported in Brazil. To date, the patient described remains without evidence of recurrence or metastasis 5 years after surgery.
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spelling Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and reviewSpindle epithelial tumor with thymus-like element (SETTLE) is a rare malignant neoplasm of the thyroid, occurring predominantly in children, adolescents, and young adults. SETTLE usually presents itself as a thyroid mass, without metastases at diagnosis. It is believed to derive from branchial pouch or thymic remnant tissue showing primitive thymic differentiation. This article reports the clinical, cytological, histological and immunohistochemical features of a SETTLE in a 3-year-old girl. Microscopic exam revealed a nodular, highly cellular neoplasm displayed in the classic biphasic pattern, with mixture of prominent spindle cell component and a minor glandular component lined by mucinous or respiratory-type epithelium. The immunohistochemical study showed strong and diffuse positivity for pan-CK, vimentin and smooth muscle actin. The present case is the first SETTLE case reported in Brazil. To date, the patient described remains without evidence of recurrence or metastasis 5 years after surgery.Sociedade Brasileira de Endocrinologia e Metabologia2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000700011Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.7 2010reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302010000700011info:eu-repo/semantics/openAccessMagnata Filho,Luiz AntônioBordallo,Maria Alice NevesPessoa,Cencita H. C. N.Corbo,RossanaBulzico,Daniel AlvesDias,Fernando LuizMachado,Avelino L.Soares,Andréia B.Ferman,Simaeng2010-11-03T00:00:00Zoai:scielo:S0004-27302010000700011Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2010-11-03T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review
title Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review
spellingShingle Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review
Magnata Filho,Luiz Antônio
title_short Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review
title_full Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review
title_fullStr Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review
title_full_unstemmed Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review
title_sort Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review
author Magnata Filho,Luiz Antônio
author_facet Magnata Filho,Luiz Antônio
Bordallo,Maria Alice Neves
Pessoa,Cencita H. C. N.
Corbo,Rossana
Bulzico,Daniel Alves
Dias,Fernando Luiz
Machado,Avelino L.
Soares,Andréia B.
Ferman,Sima
author_role author
author2 Bordallo,Maria Alice Neves
Pessoa,Cencita H. C. N.
Corbo,Rossana
Bulzico,Daniel Alves
Dias,Fernando Luiz
Machado,Avelino L.
Soares,Andréia B.
Ferman,Sima
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Magnata Filho,Luiz Antônio
Bordallo,Maria Alice Neves
Pessoa,Cencita H. C. N.
Corbo,Rossana
Bulzico,Daniel Alves
Dias,Fernando Luiz
Machado,Avelino L.
Soares,Andréia B.
Ferman,Sima
description Spindle epithelial tumor with thymus-like element (SETTLE) is a rare malignant neoplasm of the thyroid, occurring predominantly in children, adolescents, and young adults. SETTLE usually presents itself as a thyroid mass, without metastases at diagnosis. It is believed to derive from branchial pouch or thymic remnant tissue showing primitive thymic differentiation. This article reports the clinical, cytological, histological and immunohistochemical features of a SETTLE in a 3-year-old girl. Microscopic exam revealed a nodular, highly cellular neoplasm displayed in the classic biphasic pattern, with mixture of prominent spindle cell component and a minor glandular component lined by mucinous or respiratory-type epithelium. The immunohistochemical study showed strong and diffuse positivity for pan-CK, vimentin and smooth muscle actin. The present case is the first SETTLE case reported in Brazil. To date, the patient described remains without evidence of recurrence or metastasis 5 years after surgery.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-01
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000700011
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dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.7 2010
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
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