Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants

Detalhes bibliográficos
Autor(a) principal: Rosário,Pedro Weslley S. do
Data de Publicação: 2006
Outros Autores: Barroso,Álvaro Luís, Rezende,Leonardo Lamego, Padrão,Eduardo Lanza, Borges,Michelle A. Ribeiro, Purisch,Saulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302006000500016
Resumo: RATIONALE: Since ovarian function is only temporarily compromised by radioiodine therapy, many women with thyroid cancer treated with radioiodine can become pregnant. The present study evaluated the evolution of these pregnancies and the consequences for the offspring. PATIENTS AND METHODS: We retrospectively analyzed 78 pregnancies of 66 women submitted to total thyroidectomy, followed by radioiodine therapy (3.7­5.5 GBq 131I, mean 4.64 GBq). In all patients, conception occurred one year after ablative therapy (mean of 30 months). Age ranged form 19 to 36 years (mean of 30.6 years) at the time of radioiodine treatment and from 23 to 39 years (mean of 32.8 years) at the time of conception. RESULTS: Four (5.1%) of the 78 pregnancies resulted in spontaneous abortions. Three (4%) of the 74 deliveries were preterm and there was no case of stillbirth. The birthweight was > 2500 g in 94.6% of the children (mean ± SD: 3350 ± 450 g) and only one infant (1.3%) presented an apparent malformation at birth (intraventricular communication). No difference in the age at the time of radioiodine therapy or conception or in radioiodine dose was observed between pregnancies with an unfavorable outcome and those with a favorable outcome. CONCLUSION: We conclude that pregnancies that occur 12 months after ablative therapy are safe.
id SBEM-2_b5bd4f7e05fc3548e68c5ea450c257e3
oai_identifier_str oai:scielo:S0004-27302006000500016
network_acronym_str SBEM-2
network_name_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository_id_str
spelling Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnantsMalformationsRadioiodineThyroid cancerRATIONALE: Since ovarian function is only temporarily compromised by radioiodine therapy, many women with thyroid cancer treated with radioiodine can become pregnant. The present study evaluated the evolution of these pregnancies and the consequences for the offspring. PATIENTS AND METHODS: We retrospectively analyzed 78 pregnancies of 66 women submitted to total thyroidectomy, followed by radioiodine therapy (3.7­5.5 GBq 131I, mean 4.64 GBq). In all patients, conception occurred one year after ablative therapy (mean of 30 months). Age ranged form 19 to 36 years (mean of 30.6 years) at the time of radioiodine treatment and from 23 to 39 years (mean of 32.8 years) at the time of conception. RESULTS: Four (5.1%) of the 78 pregnancies resulted in spontaneous abortions. Three (4%) of the 74 deliveries were preterm and there was no case of stillbirth. The birthweight was > 2500 g in 94.6% of the children (mean ± SD: 3350 ± 450 g) and only one infant (1.3%) presented an apparent malformation at birth (intraventricular communication). No difference in the age at the time of radioiodine therapy or conception or in radioiodine dose was observed between pregnancies with an unfavorable outcome and those with a favorable outcome. CONCLUSION: We conclude that pregnancies that occur 12 months after ablative therapy are safe.Sociedade Brasileira de Endocrinologia e Metabologia2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302006000500016Arquivos Brasileiros de Endocrinologia & Metabologia v.50 n.5 2006reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302006000500016info:eu-repo/semantics/openAccessRosário,Pedro Weslley S. doBarroso,Álvaro LuísRezende,Leonardo LamegoPadrão,Eduardo LanzaBorges,Michelle A. RibeiroPurisch,Sauloeng2006-12-04T00:00:00Zoai:scielo:S0004-27302006000500016Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2006-12-04T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants
title Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants
spellingShingle Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants
Rosário,Pedro Weslley S. do
Malformations
Radioiodine
Thyroid cancer
title_short Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants
title_full Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants
title_fullStr Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants
title_full_unstemmed Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants
title_sort Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants
author Rosário,Pedro Weslley S. do
author_facet Rosário,Pedro Weslley S. do
Barroso,Álvaro Luís
Rezende,Leonardo Lamego
Padrão,Eduardo Lanza
Borges,Michelle A. Ribeiro
Purisch,Saulo
author_role author
author2 Barroso,Álvaro Luís
Rezende,Leonardo Lamego
Padrão,Eduardo Lanza
Borges,Michelle A. Ribeiro
Purisch,Saulo
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rosário,Pedro Weslley S. do
Barroso,Álvaro Luís
Rezende,Leonardo Lamego
Padrão,Eduardo Lanza
Borges,Michelle A. Ribeiro
Purisch,Saulo
dc.subject.por.fl_str_mv Malformations
Radioiodine
Thyroid cancer
topic Malformations
Radioiodine
Thyroid cancer
description RATIONALE: Since ovarian function is only temporarily compromised by radioiodine therapy, many women with thyroid cancer treated with radioiodine can become pregnant. The present study evaluated the evolution of these pregnancies and the consequences for the offspring. PATIENTS AND METHODS: We retrospectively analyzed 78 pregnancies of 66 women submitted to total thyroidectomy, followed by radioiodine therapy (3.7­5.5 GBq 131I, mean 4.64 GBq). In all patients, conception occurred one year after ablative therapy (mean of 30 months). Age ranged form 19 to 36 years (mean of 30.6 years) at the time of radioiodine treatment and from 23 to 39 years (mean of 32.8 years) at the time of conception. RESULTS: Four (5.1%) of the 78 pregnancies resulted in spontaneous abortions. Three (4%) of the 74 deliveries were preterm and there was no case of stillbirth. The birthweight was > 2500 g in 94.6% of the children (mean ± SD: 3350 ± 450 g) and only one infant (1.3%) presented an apparent malformation at birth (intraventricular communication). No difference in the age at the time of radioiodine therapy or conception or in radioiodine dose was observed between pregnancies with an unfavorable outcome and those with a favorable outcome. CONCLUSION: We conclude that pregnancies that occur 12 months after ablative therapy are safe.
publishDate 2006
dc.date.none.fl_str_mv 2006-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302006000500016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302006000500016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302006000500016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.50 n.5 2006
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
_version_ 1754734808470126592