Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndrome

Detalhes bibliográficos
Autor(a) principal: Fernández-Rodríguez,Eva
Data de Publicação: 2008
Outros Autores: Villar-Taibo,Rocío, Pinal-Osorio,Iria, Cabezas-Agrícola,José Manuel, Anido-Herranz,Urbano, Prieto,Alma, Casanueva,Felipe F, Araujo-Vilar,David
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000600019
Resumo: Ectopic ACTH production occurs in about 10% of all cases of Cushing's syndrome, and about 25% of cases of ACTH-dependent Cushing's syndrome. Diverse tumor types are able to produce ACTH ectopically, including small cell lung carcinoma. Ectopic ACTH secretion by malignant neoplasm has been reported to have earlier and more aggressive metabolic effects. We report a 59-year-old male patient with severe hypertension, metabolic alkalosis and hypokalemia as the first clinical manifestations of an ACTH-secreting small cell lung carcinoma, although the typical phenotypic features of Cushing's syndrome were not present. Ectopic Cushing's syndrome should always be ruled out in patients with severe hypertension and hypokalemia.
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spelling Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndromeCushing's syndromeEctopic ACTH productionSmall cell lung cancerHypokalemiaEctopic ACTH production occurs in about 10% of all cases of Cushing's syndrome, and about 25% of cases of ACTH-dependent Cushing's syndrome. Diverse tumor types are able to produce ACTH ectopically, including small cell lung carcinoma. Ectopic ACTH secretion by malignant neoplasm has been reported to have earlier and more aggressive metabolic effects. We report a 59-year-old male patient with severe hypertension, metabolic alkalosis and hypokalemia as the first clinical manifestations of an ACTH-secreting small cell lung carcinoma, although the typical phenotypic features of Cushing's syndrome were not present. Ectopic Cushing's syndrome should always be ruled out in patients with severe hypertension and hypokalemia.Sociedade Brasileira de Endocrinologia e Metabologia2008-08-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000600019Arquivos Brasileiros de Endocrinologia & Metabologia v.52 n.6 2008reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302008000600019info:eu-repo/semantics/openAccessFernández-Rodríguez,EvaVillar-Taibo,RocíoPinal-Osorio,IriaCabezas-Agrícola,José ManuelAnido-Herranz,UrbanoPrieto,AlmaCasanueva,Felipe FAraujo-Vilar,Davideng2008-09-17T00:00:00Zoai:scielo:S0004-27302008000600019Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2008-09-17T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndrome
title Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndrome
spellingShingle Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndrome
Fernández-Rodríguez,Eva
Cushing's syndrome
Ectopic ACTH production
Small cell lung cancer
Hypokalemia
title_short Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndrome
title_full Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndrome
title_fullStr Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndrome
title_full_unstemmed Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndrome
title_sort Severe hypertension and hypokalemia as first clinical manifestations in ectopic Cushing's syndrome
author Fernández-Rodríguez,Eva
author_facet Fernández-Rodríguez,Eva
Villar-Taibo,Rocío
Pinal-Osorio,Iria
Cabezas-Agrícola,José Manuel
Anido-Herranz,Urbano
Prieto,Alma
Casanueva,Felipe F
Araujo-Vilar,David
author_role author
author2 Villar-Taibo,Rocío
Pinal-Osorio,Iria
Cabezas-Agrícola,José Manuel
Anido-Herranz,Urbano
Prieto,Alma
Casanueva,Felipe F
Araujo-Vilar,David
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernández-Rodríguez,Eva
Villar-Taibo,Rocío
Pinal-Osorio,Iria
Cabezas-Agrícola,José Manuel
Anido-Herranz,Urbano
Prieto,Alma
Casanueva,Felipe F
Araujo-Vilar,David
dc.subject.por.fl_str_mv Cushing's syndrome
Ectopic ACTH production
Small cell lung cancer
Hypokalemia
topic Cushing's syndrome
Ectopic ACTH production
Small cell lung cancer
Hypokalemia
description Ectopic ACTH production occurs in about 10% of all cases of Cushing's syndrome, and about 25% of cases of ACTH-dependent Cushing's syndrome. Diverse tumor types are able to produce ACTH ectopically, including small cell lung carcinoma. Ectopic ACTH secretion by malignant neoplasm has been reported to have earlier and more aggressive metabolic effects. We report a 59-year-old male patient with severe hypertension, metabolic alkalosis and hypokalemia as the first clinical manifestations of an ACTH-secreting small cell lung carcinoma, although the typical phenotypic features of Cushing's syndrome were not present. Ectopic Cushing's syndrome should always be ruled out in patients with severe hypertension and hypokalemia.
publishDate 2008
dc.date.none.fl_str_mv 2008-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000600019
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302008000600019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302008000600019
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.52 n.6 2008
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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