Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000400004 |
Resumo: | OBJECTIVE: To evaluate the frequency of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (DM2) and to describe its risk factors. SUBJECTS AND METHODS: Blood samples of 78 patients were collected for assessment of glycemic and lipid profile, liver enzymes, TNF-α and HOMA-IR. The diagnosis of NAFLD was established by ultrasound. RESULTS: NAFLD was observed in 42% of patients who had greater BMI (p < 0.001), and frequency of hypertension (p < 0.001). Metabolic syndrome was more frequent in those with NAFLD (p = 0.019). The levels of aspartate, alanine aminotransferase, γ-glutamyl transpeptidase, uric acid, TNF-α, insulin and HOMA-IR were significantly higher in patients with NAFLD than those without NAFLD. CONCLUSION: Almost half of patients with DM2 were found to have NAFLD, and they have more elevated BMI, as well as higher levels of aminotransferases, γ-GT, uric acid, TNF-α, insulin and HOMA-IR than subjects without NAFLD. |
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Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitusNAFLDdiabetes mellitusinsulin resistanceHOMA-IRTNF-αOBJECTIVE: To evaluate the frequency of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (DM2) and to describe its risk factors. SUBJECTS AND METHODS: Blood samples of 78 patients were collected for assessment of glycemic and lipid profile, liver enzymes, TNF-α and HOMA-IR. The diagnosis of NAFLD was established by ultrasound. RESULTS: NAFLD was observed in 42% of patients who had greater BMI (p < 0.001), and frequency of hypertension (p < 0.001). Metabolic syndrome was more frequent in those with NAFLD (p = 0.019). The levels of aspartate, alanine aminotransferase, γ-glutamyl transpeptidase, uric acid, TNF-α, insulin and HOMA-IR were significantly higher in patients with NAFLD than those without NAFLD. CONCLUSION: Almost half of patients with DM2 were found to have NAFLD, and they have more elevated BMI, as well as higher levels of aminotransferases, γ-GT, uric acid, TNF-α, insulin and HOMA-IR than subjects without NAFLD.Sociedade Brasileira de Endocrinologia e Metabologia2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000400004Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.4 2010reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302010000400004info:eu-repo/semantics/openAccessFerreira,Vera S. G.Pernambuco,Ricardo B.Lopes,Edmundo P.Morais,Clarice N.Rodrigues,Marbiana C.Arruda,Maria JulianaSilva,Lidiane Moura eVilar,Lucioeng2010-06-29T00:00:00Zoai:scielo:S0004-27302010000400004Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2010-06-29T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false |
dc.title.none.fl_str_mv |
Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus |
title |
Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus |
spellingShingle |
Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus Ferreira,Vera S. G. NAFLD diabetes mellitus insulin resistance HOMA-IR TNF-α |
title_short |
Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus |
title_full |
Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus |
title_fullStr |
Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus |
title_full_unstemmed |
Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus |
title_sort |
Frequency and risk factors associated with non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus |
author |
Ferreira,Vera S. G. |
author_facet |
Ferreira,Vera S. G. Pernambuco,Ricardo B. Lopes,Edmundo P. Morais,Clarice N. Rodrigues,Marbiana C. Arruda,Maria Juliana Silva,Lidiane Moura e Vilar,Lucio |
author_role |
author |
author2 |
Pernambuco,Ricardo B. Lopes,Edmundo P. Morais,Clarice N. Rodrigues,Marbiana C. Arruda,Maria Juliana Silva,Lidiane Moura e Vilar,Lucio |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira,Vera S. G. Pernambuco,Ricardo B. Lopes,Edmundo P. Morais,Clarice N. Rodrigues,Marbiana C. Arruda,Maria Juliana Silva,Lidiane Moura e Vilar,Lucio |
dc.subject.por.fl_str_mv |
NAFLD diabetes mellitus insulin resistance HOMA-IR TNF-α |
topic |
NAFLD diabetes mellitus insulin resistance HOMA-IR TNF-α |
description |
OBJECTIVE: To evaluate the frequency of non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (DM2) and to describe its risk factors. SUBJECTS AND METHODS: Blood samples of 78 patients were collected for assessment of glycemic and lipid profile, liver enzymes, TNF-α and HOMA-IR. The diagnosis of NAFLD was established by ultrasound. RESULTS: NAFLD was observed in 42% of patients who had greater BMI (p < 0.001), and frequency of hypertension (p < 0.001). Metabolic syndrome was more frequent in those with NAFLD (p = 0.019). The levels of aspartate, alanine aminotransferase, γ-glutamyl transpeptidase, uric acid, TNF-α, insulin and HOMA-IR were significantly higher in patients with NAFLD than those without NAFLD. CONCLUSION: Almost half of patients with DM2 were found to have NAFLD, and they have more elevated BMI, as well as higher levels of aminotransferases, γ-GT, uric acid, TNF-α, insulin and HOMA-IR than subjects without NAFLD. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000400004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000400004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27302010000400004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Endocrinologia e Metabologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia v.54 n.4 2010 reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online) instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
instname_str |
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
instacron_str |
SBEM |
institution |
SBEM |
reponame_str |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
collection |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) |
repository.name.fl_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) |
repository.mail.fl_str_mv |
||abem-editoria@endocrino.org.br |
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1754734810975174656 |