Normal values of serum IGF-1 in adults: results from a Brazilian population

• Autor(a) principal: Rosario,Pedro Weslley
• Data de Publicação: 2010
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000500008
• topic: IGF-1; immulite assay; normal values; adults

OBJECTIVE: To determine the normal values of serum IGF-1 (Immulite 2000) in a Brazilian adult (21-70 years) population. SUBJECTS AND METHODS: Healthy volunteers were divided into 10 groups according to age (5-year intervals), with 100 subjects (50 men and 50 women) per group. One-hundred participants were selected for repetition of the test after 12 weeks. RESULTS: No difference in IGF-1 values was observed between men and women, but a progressive reduction of serum IGF-1 with age was seen. The reference values provided by the manufacturer of the assay, although discretely higher, were very close to the values found in this study. A second measurement of IGF-1 after 12 weeks revealed a variation < 20% in 99% of subjects. CONCLUSIONS: This study established the reference range for IGF-1 determined with the Immulite 2000 assay for a large number of healthy Brazilian adults stratified according to age, and suggests that variations &gt; 20% in IGF-1 levels within an interval of 12 weeks cannot be attributed to interassay variability.