Changes in prolactin secretion in the short- and long-term after adrenalectomy

Detalhes bibliográficos
Autor(a) principal: Laguna-Abreu,Maria Thereza C.
Data de Publicação: 2012
Outros Autores: Germano,Carla, Moreira,Ayrton C., Antunes-Rodrigues,José, Elias,Lucila, Castro,Margaret
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400005
Resumo: OBJECTIVE: To evaluate the modulation of the hypothalamus-pituitary-adrenal axis (HPA) on prolactin secretion in rats after adrenalectomy (ADX). MATERIALS AND METHODS: Plasma corticosterone, ACTH, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral ADX in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). RESULTS: Animals that underwent ADX showed undetectable corticosterone levels and a triphasic ACTH response with a transient increase (3h), a decrease (1d), and further increase in the long-term after ADX. Sham animals showed a marked increase in corticosterone and ACTH levels three hours after surgery, with a decrease to basal levels thereafter. Plasma prolactin levels were not changed after ADX. CONCLUSION: There are different points of equilibrium in the HPA axis after the glucocorticoid negative feedback is removed. Prolactin plasma secretion is not altered in the short or long- term after ADX, suggesting that the peptidergic neurons essential for prolactin release are not activated after ADX.
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spelling Changes in prolactin secretion in the short- and long-term after adrenalectomyAdrenalectomyprolactincorticosteroneadrenocorticotropic hormoneOBJECTIVE: To evaluate the modulation of the hypothalamus-pituitary-adrenal axis (HPA) on prolactin secretion in rats after adrenalectomy (ADX). MATERIALS AND METHODS: Plasma corticosterone, ACTH, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral ADX in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). RESULTS: Animals that underwent ADX showed undetectable corticosterone levels and a triphasic ACTH response with a transient increase (3h), a decrease (1d), and further increase in the long-term after ADX. Sham animals showed a marked increase in corticosterone and ACTH levels three hours after surgery, with a decrease to basal levels thereafter. Plasma prolactin levels were not changed after ADX. CONCLUSION: There are different points of equilibrium in the HPA axis after the glucocorticoid negative feedback is removed. Prolactin plasma secretion is not altered in the short or long- term after ADX, suggesting that the peptidergic neurons essential for prolactin release are not activated after ADX.Sociedade Brasileira de Endocrinologia e Metabologia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400005Arquivos Brasileiros de Endocrinologia & Metabologia v.56 n.4 2012reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302012000400005info:eu-repo/semantics/openAccessLaguna-Abreu,Maria Thereza C.Germano,CarlaMoreira,Ayrton C.Antunes-Rodrigues,JoséElias,LucilaCastro,Margareteng2012-07-11T00:00:00Zoai:scielo:S0004-27302012000400005Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2012-07-11T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Changes in prolactin secretion in the short- and long-term after adrenalectomy
title Changes in prolactin secretion in the short- and long-term after adrenalectomy
spellingShingle Changes in prolactin secretion in the short- and long-term after adrenalectomy
Laguna-Abreu,Maria Thereza C.
Adrenalectomy
prolactin
corticosterone
adrenocorticotropic hormone
title_short Changes in prolactin secretion in the short- and long-term after adrenalectomy
title_full Changes in prolactin secretion in the short- and long-term after adrenalectomy
title_fullStr Changes in prolactin secretion in the short- and long-term after adrenalectomy
title_full_unstemmed Changes in prolactin secretion in the short- and long-term after adrenalectomy
title_sort Changes in prolactin secretion in the short- and long-term after adrenalectomy
author Laguna-Abreu,Maria Thereza C.
author_facet Laguna-Abreu,Maria Thereza C.
Germano,Carla
Moreira,Ayrton C.
Antunes-Rodrigues,José
Elias,Lucila
Castro,Margaret
author_role author
author2 Germano,Carla
Moreira,Ayrton C.
Antunes-Rodrigues,José
Elias,Lucila
Castro,Margaret
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Laguna-Abreu,Maria Thereza C.
Germano,Carla
Moreira,Ayrton C.
Antunes-Rodrigues,José
Elias,Lucila
Castro,Margaret
dc.subject.por.fl_str_mv Adrenalectomy
prolactin
corticosterone
adrenocorticotropic hormone
topic Adrenalectomy
prolactin
corticosterone
adrenocorticotropic hormone
description OBJECTIVE: To evaluate the modulation of the hypothalamus-pituitary-adrenal axis (HPA) on prolactin secretion in rats after adrenalectomy (ADX). MATERIALS AND METHODS: Plasma corticosterone, ACTH, and prolactin concentrations were measured by radioimmunoassay in rats after bilateral ADX in the short- (3 hours and 1day) and long-term (3, 7, and 14 days). RESULTS: Animals that underwent ADX showed undetectable corticosterone levels and a triphasic ACTH response with a transient increase (3h), a decrease (1d), and further increase in the long-term after ADX. Sham animals showed a marked increase in corticosterone and ACTH levels three hours after surgery, with a decrease to basal levels thereafter. Plasma prolactin levels were not changed after ADX. CONCLUSION: There are different points of equilibrium in the HPA axis after the glucocorticoid negative feedback is removed. Prolactin plasma secretion is not altered in the short or long- term after ADX, suggesting that the peptidergic neurons essential for prolactin release are not activated after ADX.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302012000400005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302012000400005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.56 n.4 2012
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
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repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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