Metabolic evaluation of young women with congenital adrenal hyperplasia

• Autor(a) principal: Schnaider-Rezek,Gabrielle Sormanti
• Data de Publicação: 2011
• Outros Autores: Lemos-Marini,Sofia Helena Valente de, Baptista,Maria Tereza Matias, Guerra-Júnior,Gil, Morcillo,André Moreno, Mello,Maricilda Palandi de, Oliveira,Laurione Cândido de, D'Souza-Li,Lilia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302011000800021
• topic: Congenital adrenal hyperplasia; insulin resistance; dyslipidemia; obesity

OBJECTIVE: To evaluate insulin resistance and lipid profile in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase deficiency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage. SUBJECTS AND METHODS: We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profile in eighteen young women (mean ± SD, 19.3 ± 3.0 years) with 21OHD CAH. RESULTS: BMI was normal in 12 patients, 5 of them were overweight, and 1 was obese. Waist circumference was high in 7 patients. Fasting insulin and HOMA-IR were elevated in seven and eight patients, respectively. Total cholesterol and triglycerides were high in only two patients, and HDL-cholesterol was low in four. Insulin resistance was not associated with BMI, waist circumference or glucocorticoid dose. CONCLUSIONS: Young women with 21OHD CAH had infrequent dyslipidemia, but had a higher prevalence of insulin resistance and central obesity, that were independent of BMI or corticosteroid dosage.