Genetic variants influencing effectiveness of weight loss strategies

Detalhes bibliográficos
Autor(a) principal: Deram,Sophie
Data de Publicação: 2009
Outros Autores: Villares,Sandra M. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200003
Resumo: Body weight excess has an increasingly high prevalence in the world. Obesity is a complex disease of multifactorial origin with a polygenic condition affected by environmental factors. Weight loss is a primary strategy to treat obesity and its morbidities. Weight changes through life depend on the interaction of environmental, behavioral and genetic factors. Interindividual variation of weight loss in response to different types of interventions (behavioral, caloric restriction, exercise, drug or surgery) has been observed. In this article, currently available data on the role of candidate gene polymorphisms in weight loss are reviewed. Even though control of weight loss by genotype was described in twin and family studies, it is premature to recommend use of genotyping in the design of therapeutic diets or drug treatment. Future studies will have to be large in order to assess the effects of multiple polymorphisms, and will have to control factors other than diet.
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spelling Genetic variants influencing effectiveness of weight loss strategiesPolymorphismsgeneticgene variantweight lossobesityBody weight excess has an increasingly high prevalence in the world. Obesity is a complex disease of multifactorial origin with a polygenic condition affected by environmental factors. Weight loss is a primary strategy to treat obesity and its morbidities. Weight changes through life depend on the interaction of environmental, behavioral and genetic factors. Interindividual variation of weight loss in response to different types of interventions (behavioral, caloric restriction, exercise, drug or surgery) has been observed. In this article, currently available data on the role of candidate gene polymorphisms in weight loss are reviewed. Even though control of weight loss by genotype was described in twin and family studies, it is premature to recommend use of genotyping in the design of therapeutic diets or drug treatment. Future studies will have to be large in order to assess the effects of multiple polymorphisms, and will have to control factors other than diet.Sociedade Brasileira de Endocrinologia e Metabologia2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200003Arquivos Brasileiros de Endocrinologia & Metabologia v.53 n.2 2009reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/S0004-27302009000200003info:eu-repo/semantics/openAccessDeram,SophieVillares,Sandra M. F.eng2015-07-02T00:00:00Zoai:scielo:S0004-27302009000200003Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2015-07-02T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Genetic variants influencing effectiveness of weight loss strategies
title Genetic variants influencing effectiveness of weight loss strategies
spellingShingle Genetic variants influencing effectiveness of weight loss strategies
Deram,Sophie
Polymorphisms
genetic
gene variant
weight loss
obesity
title_short Genetic variants influencing effectiveness of weight loss strategies
title_full Genetic variants influencing effectiveness of weight loss strategies
title_fullStr Genetic variants influencing effectiveness of weight loss strategies
title_full_unstemmed Genetic variants influencing effectiveness of weight loss strategies
title_sort Genetic variants influencing effectiveness of weight loss strategies
author Deram,Sophie
author_facet Deram,Sophie
Villares,Sandra M. F.
author_role author
author2 Villares,Sandra M. F.
author2_role author
dc.contributor.author.fl_str_mv Deram,Sophie
Villares,Sandra M. F.
dc.subject.por.fl_str_mv Polymorphisms
genetic
gene variant
weight loss
obesity
topic Polymorphisms
genetic
gene variant
weight loss
obesity
description Body weight excess has an increasingly high prevalence in the world. Obesity is a complex disease of multifactorial origin with a polygenic condition affected by environmental factors. Weight loss is a primary strategy to treat obesity and its morbidities. Weight changes through life depend on the interaction of environmental, behavioral and genetic factors. Interindividual variation of weight loss in response to different types of interventions (behavioral, caloric restriction, exercise, drug or surgery) has been observed. In this article, currently available data on the role of candidate gene polymorphisms in weight loss are reviewed. Even though control of weight loss by genotype was described in twin and family studies, it is premature to recommend use of genotyping in the design of therapeutic diets or drug treatment. Future studies will have to be large in order to assess the effects of multiple polymorphisms, and will have to control factors other than diet.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302009000200003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27302009000200003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.53 n.2 2009
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
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collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
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repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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