Study of neutron-DNA interaction at the IPEN BNCT research facility

Detalhes bibliográficos
Autor(a) principal: Gual,M. R.
Data de Publicação: 2004
Outros Autores: Rodriguez,O., Guzman,F., Deppman,A., Arruda Neto,J. D.T., Likhachev,V.P., Coelho,Paulo R. P., Siqueira,P.T.D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Physics
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-97332004000500052
Resumo: Our group at the Laboratorio do Acelerador Linear (IFUSP- USP) is currently developing several studies related to the interaction of different kinds of radiation with DNA. Initially, our plan is to study the interactions proton-DNA, gamma-DNA and neutron-DNA. In this work we describe the most important features of the neutron-DNA study, which we plan to perform by selecting thermal, epithermal and fast neutrons. To improve the information about radiation-DNA interaction is important in order to achieve more secure and efficient cancer treatments by using radiation therapy. Nowadays, one important technique is the boron neutrons capture therapy, where neutrons are used to initiate a nuclear reaction at the tumor site. The effects of the neutrons on the health tissue, however, must be better understood. The study of neutron-DNA interaction, in this scenario, is of great importance. The research facility for Boron Neutron Capture Therapy (BNCT) in the IEA-R1 Reactor of the IPEN-CNEN/SP[1] will be used for studying the neutron-induced DNA damage. At present, we are evaluating the characteristics of the neutron flux at the biological sample, and we are carrying out simulations of the experimental procedure through Monte Carlos N Particle transport code system version 4C (MCNP-4C)[2] to find the experimental conditions necessary to minimize such contamination, and also verify the effects of those gamma's on the DNA molecule. The first step is the selection of filters configurations, which will allow us to irradiate the DNA sample with thermal, epithermal and fast neutrons. We present the results of our simulations, and describe the experimental setup show the best sets of materials necessary to obtain neutron spectra for different neutrons energies.
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spelling Study of neutron-DNA interaction at the IPEN BNCT research facilityOur group at the Laboratorio do Acelerador Linear (IFUSP- USP) is currently developing several studies related to the interaction of different kinds of radiation with DNA. Initially, our plan is to study the interactions proton-DNA, gamma-DNA and neutron-DNA. In this work we describe the most important features of the neutron-DNA study, which we plan to perform by selecting thermal, epithermal and fast neutrons. To improve the information about radiation-DNA interaction is important in order to achieve more secure and efficient cancer treatments by using radiation therapy. Nowadays, one important technique is the boron neutrons capture therapy, where neutrons are used to initiate a nuclear reaction at the tumor site. The effects of the neutrons on the health tissue, however, must be better understood. The study of neutron-DNA interaction, in this scenario, is of great importance. The research facility for Boron Neutron Capture Therapy (BNCT) in the IEA-R1 Reactor of the IPEN-CNEN/SP[1] will be used for studying the neutron-induced DNA damage. At present, we are evaluating the characteristics of the neutron flux at the biological sample, and we are carrying out simulations of the experimental procedure through Monte Carlos N Particle transport code system version 4C (MCNP-4C)[2] to find the experimental conditions necessary to minimize such contamination, and also verify the effects of those gamma's on the DNA molecule. The first step is the selection of filters configurations, which will allow us to irradiate the DNA sample with thermal, epithermal and fast neutrons. We present the results of our simulations, and describe the experimental setup show the best sets of materials necessary to obtain neutron spectra for different neutrons energies.Sociedade Brasileira de Física2004-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-97332004000500052Brazilian Journal of Physics v.34 n.3a 2004reponame:Brazilian Journal of Physicsinstname:Sociedade Brasileira de Física (SBF)instacron:SBF10.1590/S0103-97332004000500052info:eu-repo/semantics/openAccessGual,M. R.Rodriguez,O.Guzman,F.Deppman,A.Arruda Neto,J. D.T.Likhachev,V.P.Coelho,Paulo R. P.Siqueira,P.T.D.eng2004-10-26T00:00:00Zoai:scielo:S0103-97332004000500052Revistahttp://www.sbfisica.org.br/v1/home/index.php/pt/ONGhttps://old.scielo.br/oai/scielo-oai.phpsbfisica@sbfisica.org.br||sbfisica@sbfisica.org.br1678-44480103-9733opendoar:2004-10-26T00:00Brazilian Journal of Physics - Sociedade Brasileira de Física (SBF)false
dc.title.none.fl_str_mv Study of neutron-DNA interaction at the IPEN BNCT research facility
title Study of neutron-DNA interaction at the IPEN BNCT research facility
spellingShingle Study of neutron-DNA interaction at the IPEN BNCT research facility
Gual,M. R.
title_short Study of neutron-DNA interaction at the IPEN BNCT research facility
title_full Study of neutron-DNA interaction at the IPEN BNCT research facility
title_fullStr Study of neutron-DNA interaction at the IPEN BNCT research facility
title_full_unstemmed Study of neutron-DNA interaction at the IPEN BNCT research facility
title_sort Study of neutron-DNA interaction at the IPEN BNCT research facility
author Gual,M. R.
author_facet Gual,M. R.
Rodriguez,O.
Guzman,F.
Deppman,A.
Arruda Neto,J. D.T.
Likhachev,V.P.
Coelho,Paulo R. P.
Siqueira,P.T.D.
author_role author
author2 Rodriguez,O.
Guzman,F.
Deppman,A.
Arruda Neto,J. D.T.
Likhachev,V.P.
Coelho,Paulo R. P.
Siqueira,P.T.D.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gual,M. R.
Rodriguez,O.
Guzman,F.
Deppman,A.
Arruda Neto,J. D.T.
Likhachev,V.P.
Coelho,Paulo R. P.
Siqueira,P.T.D.
description Our group at the Laboratorio do Acelerador Linear (IFUSP- USP) is currently developing several studies related to the interaction of different kinds of radiation with DNA. Initially, our plan is to study the interactions proton-DNA, gamma-DNA and neutron-DNA. In this work we describe the most important features of the neutron-DNA study, which we plan to perform by selecting thermal, epithermal and fast neutrons. To improve the information about radiation-DNA interaction is important in order to achieve more secure and efficient cancer treatments by using radiation therapy. Nowadays, one important technique is the boron neutrons capture therapy, where neutrons are used to initiate a nuclear reaction at the tumor site. The effects of the neutrons on the health tissue, however, must be better understood. The study of neutron-DNA interaction, in this scenario, is of great importance. The research facility for Boron Neutron Capture Therapy (BNCT) in the IEA-R1 Reactor of the IPEN-CNEN/SP[1] will be used for studying the neutron-induced DNA damage. At present, we are evaluating the characteristics of the neutron flux at the biological sample, and we are carrying out simulations of the experimental procedure through Monte Carlos N Particle transport code system version 4C (MCNP-4C)[2] to find the experimental conditions necessary to minimize such contamination, and also verify the effects of those gamma's on the DNA molecule. The first step is the selection of filters configurations, which will allow us to irradiate the DNA sample with thermal, epithermal and fast neutrons. We present the results of our simulations, and describe the experimental setup show the best sets of materials necessary to obtain neutron spectra for different neutrons energies.
publishDate 2004
dc.date.none.fl_str_mv 2004-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-97332004000500052
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S0103-97332004000500052
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Física
publisher.none.fl_str_mv Sociedade Brasileira de Física
dc.source.none.fl_str_mv Brazilian Journal of Physics v.34 n.3a 2004
reponame:Brazilian Journal of Physics
instname:Sociedade Brasileira de Física (SBF)
instacron:SBF
instname_str Sociedade Brasileira de Física (SBF)
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reponame_str Brazilian Journal of Physics
collection Brazilian Journal of Physics
repository.name.fl_str_mv Brazilian Journal of Physics - Sociedade Brasileira de Física (SBF)
repository.mail.fl_str_mv sbfisica@sbfisica.org.br||sbfisica@sbfisica.org.br
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