Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | CoDAS |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822014000300219 |
Resumo: | PURPOSE: To verify the association between the amplitude of distortion-product otoacoustic emissions (DPOAE) and biomarkers of oxidative stress (OS) in resident students of the tobacco-producing region. METHODS: Participated in the study group (SG) 21 normal-hearing students from the tobacco-producing region, and in the control group (CG) 25 normal-hearing students who did not live in the countryside. The auditory system was assessed by DPOAE and the following biomarkers: dichlorofluorescein diacetate (DCFH-DA) and micronucleus test (MN). RESULTS: Both groups showed DPOAE present in both ears. Significant difference was detected between groups - in the right ear in the frequency of 4.000 Hz and in the left ear in the frequency of 2.000 Hz - with the mean amplitude of the DPOAE of the SG lower than the one found in the CG. Considering both ears, the SG presented lower mean across all frequencies and it was found a significant difference in the frequencies of 2.000 and 4.000 Hz. The overall mean of DPOAE, by ear, no significant differences were observed. In relation to the rate of production of free radicals, the mean of the SG was significantly higher than that of the mean of the CG. For the frequency of abnormal cells in the MN test, the mean of the SG was also considerate significantly higher than the mean of the CG. CONCLUSION: The SG showed a lower response level of DPOAE at all frequencies and high levels of biomarkers of EO, however there was no association between assessments. |
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Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing regionPesticidesTobaccoHearingOxidative StressChild PURPOSE: To verify the association between the amplitude of distortion-product otoacoustic emissions (DPOAE) and biomarkers of oxidative stress (OS) in resident students of the tobacco-producing region. METHODS: Participated in the study group (SG) 21 normal-hearing students from the tobacco-producing region, and in the control group (CG) 25 normal-hearing students who did not live in the countryside. The auditory system was assessed by DPOAE and the following biomarkers: dichlorofluorescein diacetate (DCFH-DA) and micronucleus test (MN). RESULTS: Both groups showed DPOAE present in both ears. Significant difference was detected between groups - in the right ear in the frequency of 4.000 Hz and in the left ear in the frequency of 2.000 Hz - with the mean amplitude of the DPOAE of the SG lower than the one found in the CG. Considering both ears, the SG presented lower mean across all frequencies and it was found a significant difference in the frequencies of 2.000 and 4.000 Hz. The overall mean of DPOAE, by ear, no significant differences were observed. In relation to the rate of production of free radicals, the mean of the SG was significantly higher than that of the mean of the CG. For the frequency of abnormal cells in the MN test, the mean of the SG was also considerate significantly higher than the mean of the CG. CONCLUSION: The SG showed a lower response level of DPOAE at all frequencies and high levels of biomarkers of EO, however there was no association between assessments. Sociedade Brasileira de Fonoaudiologia2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822014000300219CoDAS v.26 n.3 2014reponame:CoDASinstname:Sociedade Brasileira de Fonoaudiologia (SBFA)instacron:SBFA10.1590/2317-1782/201420140489info:eu-repo/semantics/openAccessKunst,Letícia ReginaGarcia,Michele VargasMachado,Alencar KolinskiBarbisan,FernandaSilveira,Aron Ferreira daeng2015-08-18T00:00:00Zoai:scielo:S2317-17822014000300219Revistahttps://www.codas.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.phpcodas@editoracubo.com.br||revista@codas.org.br2317-17822317-1782opendoar:2015-08-18T00:00CoDAS - Sociedade Brasileira de Fonoaudiologia (SBFA)false |
dc.title.none.fl_str_mv |
Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region |
title |
Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region |
spellingShingle |
Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region Kunst,Letícia Regina Pesticides Tobacco Hearing Oxidative Stress Child |
title_short |
Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region |
title_full |
Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region |
title_fullStr |
Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region |
title_full_unstemmed |
Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region |
title_sort |
Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region |
author |
Kunst,Letícia Regina |
author_facet |
Kunst,Letícia Regina Garcia,Michele Vargas Machado,Alencar Kolinski Barbisan,Fernanda Silveira,Aron Ferreira da |
author_role |
author |
author2 |
Garcia,Michele Vargas Machado,Alencar Kolinski Barbisan,Fernanda Silveira,Aron Ferreira da |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Kunst,Letícia Regina Garcia,Michele Vargas Machado,Alencar Kolinski Barbisan,Fernanda Silveira,Aron Ferreira da |
dc.subject.por.fl_str_mv |
Pesticides Tobacco Hearing Oxidative Stress Child |
topic |
Pesticides Tobacco Hearing Oxidative Stress Child |
description |
PURPOSE: To verify the association between the amplitude of distortion-product otoacoustic emissions (DPOAE) and biomarkers of oxidative stress (OS) in resident students of the tobacco-producing region. METHODS: Participated in the study group (SG) 21 normal-hearing students from the tobacco-producing region, and in the control group (CG) 25 normal-hearing students who did not live in the countryside. The auditory system was assessed by DPOAE and the following biomarkers: dichlorofluorescein diacetate (DCFH-DA) and micronucleus test (MN). RESULTS: Both groups showed DPOAE present in both ears. Significant difference was detected between groups - in the right ear in the frequency of 4.000 Hz and in the left ear in the frequency of 2.000 Hz - with the mean amplitude of the DPOAE of the SG lower than the one found in the CG. Considering both ears, the SG presented lower mean across all frequencies and it was found a significant difference in the frequencies of 2.000 and 4.000 Hz. The overall mean of DPOAE, by ear, no significant differences were observed. In relation to the rate of production of free radicals, the mean of the SG was significantly higher than that of the mean of the CG. For the frequency of abnormal cells in the MN test, the mean of the SG was also considerate significantly higher than the mean of the CG. CONCLUSION: The SG showed a lower response level of DPOAE at all frequencies and high levels of biomarkers of EO, however there was no association between assessments. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822014000300219 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822014000300219 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/2317-1782/201420140489 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Fonoaudiologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Fonoaudiologia |
dc.source.none.fl_str_mv |
CoDAS v.26 n.3 2014 reponame:CoDAS instname:Sociedade Brasileira de Fonoaudiologia (SBFA) instacron:SBFA |
instname_str |
Sociedade Brasileira de Fonoaudiologia (SBFA) |
instacron_str |
SBFA |
institution |
SBFA |
reponame_str |
CoDAS |
collection |
CoDAS |
repository.name.fl_str_mv |
CoDAS - Sociedade Brasileira de Fonoaudiologia (SBFA) |
repository.mail.fl_str_mv |
codas@editoracubo.com.br||revista@codas.org.br |
_version_ |
1752122440350171136 |