Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region

Detalhes bibliográficos
Autor(a) principal: Kunst,Letícia Regina
Data de Publicação: 2014
Outros Autores: Garcia,Michele Vargas, Machado,Alencar Kolinski, Barbisan,Fernanda, Silveira,Aron Ferreira da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: CoDAS
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822014000300219
Resumo: PURPOSE: To verify the association between the amplitude of distortion-product otoacoustic emissions (DPOAE) and biomarkers of oxidative stress (OS) in resident students of the tobacco-producing region. METHODS: Participated in the study group (SG) 21 normal-hearing students from the tobacco-producing region, and in the control group (CG) 25 normal-hearing students who did not live in the countryside. The auditory system was assessed by DPOAE and the following biomarkers: dichlorofluorescein diacetate (DCFH-DA) and micronucleus test (MN). RESULTS: Both groups showed DPOAE present in both ears. Significant difference was detected between groups - in the right ear in the frequency of 4.000 Hz and in the left ear in the frequency of 2.000 Hz - with the mean amplitude of the DPOAE of the SG lower than the one found in the CG. Considering both ears, the SG presented lower mean across all frequencies and it was found a significant difference in the frequencies of 2.000 and 4.000 Hz. The overall mean of DPOAE, by ear, no significant differences were observed. In relation to the rate of production of free radicals, the mean of the SG was significantly higher than that of the mean of the CG. For the frequency of abnormal cells in the MN test, the mean of the SG was also considerate significantly higher than the mean of the CG. CONCLUSION: The SG showed a lower response level of DPOAE at all frequencies and high levels of biomarkers of EO, however there was no association between assessments.
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spelling Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing regionPesticidesTobaccoHearingOxidative StressChild PURPOSE: To verify the association between the amplitude of distortion-product otoacoustic emissions (DPOAE) and biomarkers of oxidative stress (OS) in resident students of the tobacco-producing region. METHODS: Participated in the study group (SG) 21 normal-hearing students from the tobacco-producing region, and in the control group (CG) 25 normal-hearing students who did not live in the countryside. The auditory system was assessed by DPOAE and the following biomarkers: dichlorofluorescein diacetate (DCFH-DA) and micronucleus test (MN). RESULTS: Both groups showed DPOAE present in both ears. Significant difference was detected between groups - in the right ear in the frequency of 4.000 Hz and in the left ear in the frequency of 2.000 Hz - with the mean amplitude of the DPOAE of the SG lower than the one found in the CG. Considering both ears, the SG presented lower mean across all frequencies and it was found a significant difference in the frequencies of 2.000 and 4.000 Hz. The overall mean of DPOAE, by ear, no significant differences were observed. In relation to the rate of production of free radicals, the mean of the SG was significantly higher than that of the mean of the CG. For the frequency of abnormal cells in the MN test, the mean of the SG was also considerate significantly higher than the mean of the CG. CONCLUSION: The SG showed a lower response level of DPOAE at all frequencies and high levels of biomarkers of EO, however there was no association between assessments. Sociedade Brasileira de Fonoaudiologia2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822014000300219CoDAS v.26 n.3 2014reponame:CoDASinstname:Sociedade Brasileira de Fonoaudiologia (SBFA)instacron:SBFA10.1590/2317-1782/201420140489info:eu-repo/semantics/openAccessKunst,Letícia ReginaGarcia,Michele VargasMachado,Alencar KolinskiBarbisan,FernandaSilveira,Aron Ferreira daeng2015-08-18T00:00:00Zoai:scielo:S2317-17822014000300219Revistahttps://www.codas.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.phpcodas@editoracubo.com.br||revista@codas.org.br2317-17822317-1782opendoar:2015-08-18T00:00CoDAS - Sociedade Brasileira de Fonoaudiologia (SBFA)false
dc.title.none.fl_str_mv Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region
title Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region
spellingShingle Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region
Kunst,Letícia Regina
Pesticides
Tobacco
Hearing
Oxidative Stress
Child
title_short Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region
title_full Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region
title_fullStr Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region
title_full_unstemmed Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region
title_sort Otoacoustic emissions and biomarkers of oxidative stress in students of a tobacco-producing region
author Kunst,Letícia Regina
author_facet Kunst,Letícia Regina
Garcia,Michele Vargas
Machado,Alencar Kolinski
Barbisan,Fernanda
Silveira,Aron Ferreira da
author_role author
author2 Garcia,Michele Vargas
Machado,Alencar Kolinski
Barbisan,Fernanda
Silveira,Aron Ferreira da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Kunst,Letícia Regina
Garcia,Michele Vargas
Machado,Alencar Kolinski
Barbisan,Fernanda
Silveira,Aron Ferreira da
dc.subject.por.fl_str_mv Pesticides
Tobacco
Hearing
Oxidative Stress
Child
topic Pesticides
Tobacco
Hearing
Oxidative Stress
Child
description PURPOSE: To verify the association between the amplitude of distortion-product otoacoustic emissions (DPOAE) and biomarkers of oxidative stress (OS) in resident students of the tobacco-producing region. METHODS: Participated in the study group (SG) 21 normal-hearing students from the tobacco-producing region, and in the control group (CG) 25 normal-hearing students who did not live in the countryside. The auditory system was assessed by DPOAE and the following biomarkers: dichlorofluorescein diacetate (DCFH-DA) and micronucleus test (MN). RESULTS: Both groups showed DPOAE present in both ears. Significant difference was detected between groups - in the right ear in the frequency of 4.000 Hz and in the left ear in the frequency of 2.000 Hz - with the mean amplitude of the DPOAE of the SG lower than the one found in the CG. Considering both ears, the SG presented lower mean across all frequencies and it was found a significant difference in the frequencies of 2.000 and 4.000 Hz. The overall mean of DPOAE, by ear, no significant differences were observed. In relation to the rate of production of free radicals, the mean of the SG was significantly higher than that of the mean of the CG. For the frequency of abnormal cells in the MN test, the mean of the SG was also considerate significantly higher than the mean of the CG. CONCLUSION: The SG showed a lower response level of DPOAE at all frequencies and high levels of biomarkers of EO, however there was no association between assessments.
publishDate 2014
dc.date.none.fl_str_mv 2014-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822014000300219
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2317-17822014000300219
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/2317-1782/201420140489
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Fonoaudiologia
publisher.none.fl_str_mv Sociedade Brasileira de Fonoaudiologia
dc.source.none.fl_str_mv CoDAS v.26 n.3 2014
reponame:CoDAS
instname:Sociedade Brasileira de Fonoaudiologia (SBFA)
instacron:SBFA
instname_str Sociedade Brasileira de Fonoaudiologia (SBFA)
instacron_str SBFA
institution SBFA
reponame_str CoDAS
collection CoDAS
repository.name.fl_str_mv CoDAS - Sociedade Brasileira de Fonoaudiologia (SBFA)
repository.mail.fl_str_mv codas@editoracubo.com.br||revista@codas.org.br
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