In vitro schistosomicidal effects of the essential oil of Tagetes erecta

• Autor(a) principal: Tonuci,Ligia R. S.
• Data de Publicação: 2012
• Outros Autores: Melo,Nathalya I. de, Dias,Herbert J., Wakabayashi,Kamila A. L., Aguiar,Gabriela P., Aguiar,Daniela P., Mantovani,André L. L., Ramos,Rafael C., Groppo,Milton, Rodrigues,Vanderlei, Veneziani,Rodrigo C. S., Cunha,Wilson R., Silva Filho,Ademar A. da, Magalhães,Lizandra G., Crotti,Antônio E. M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100013
• topic: essential oil; praziquantel; Schistosoma mansoni; schistosomicidal agents; Tagetes erecta

The in vitro schistosomicidal effects of the essential oil obtained from Tagetes erecta L. Asteraceae, leaves (TE-EO) collected in Brazil against Schistosoma mansoni worms are reported in this paper. The oil caused a significant decrease in the motor activity at 50 µg/mL as minimal concentration after 24 h. This oil also caused death of all the parasites and the separation of coupled pairs into individual male and female at 100 µg/mL after 24 h. The viability of adult worm groups treated with the TE-EO at 100 µg/mL was similar to that of groups treated with praziquantel (positive control). In addition, the oil promoted the inhibition of eggs development at all the tested concentrations. These data indicate that the TE-EO could be considered as a promising source for the development of new schistosomicidal agents.