Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000100007 |
Resumo: | Calea pinnatifida (R. Br.) Less., Asteraceae, is popularly known as “quebra-tudo”, “cipó-cruz” or “aruca”. This species is used in the folk medicine for the treatment of stomach pain, giardiasis and amoebiasis. The aim of this study was to isolate and identify chromenes from leaves of C. pinnatifida and evaluate their leishmanicidal activity. A fraction from leaves of C. pinnatifida was analyzed for their chemical constituents, resulting in the isolation and characterization of four known chromenes: 6-acetyl-7-hydroxy-2,2-dimethylchromene (1), 6-acetyl-7-methoxy-2,2-dimethylchromene (2), 6-(1-hydroxyethyl)-7-methoxy-2,2-dimethylchromene (3) and 6-(1-ethoxyethyl)-7-methoxy-2,2-dimethylchromene (4). Structure identification of isolated compounds involved analysis of spectral data of 1D and 2D-NMR. The isolated compounds are here reported for the first time in C. pinnatifida, and the chromenes 1 and 3 show a moderate leishmanicidal activity. |
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Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activityAsteraceaeCalea pinnatifidaChromenesLeishmanicidal activityCalea pinnatifida (R. Br.) Less., Asteraceae, is popularly known as “quebra-tudo”, “cipó-cruz” or “aruca”. This species is used in the folk medicine for the treatment of stomach pain, giardiasis and amoebiasis. The aim of this study was to isolate and identify chromenes from leaves of C. pinnatifida and evaluate their leishmanicidal activity. A fraction from leaves of C. pinnatifida was analyzed for their chemical constituents, resulting in the isolation and characterization of four known chromenes: 6-acetyl-7-hydroxy-2,2-dimethylchromene (1), 6-acetyl-7-methoxy-2,2-dimethylchromene (2), 6-(1-hydroxyethyl)-7-methoxy-2,2-dimethylchromene (3) and 6-(1-ethoxyethyl)-7-methoxy-2,2-dimethylchromene (4). Structure identification of isolated compounds involved analysis of spectral data of 1D and 2D-NMR. The isolated compounds are here reported for the first time in C. pinnatifida, and the chromenes 1 and 3 show a moderate leishmanicidal activity.Sociedade Brasileira de Farmacognosia2015-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000100007Revista Brasileira de Farmacognosia v.25 n.1 2015reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.01.004info:eu-repo/semantics/openAccessLima,Tamires C.Santos,Alan Diego C.Costa,Danielle T.M.Souza,Rafaela J.Barison,AnderssonSteindel,MárioBiavatti,Maique W.eng2015-09-10T00:00:00Zoai:scielo:S0102-695X2015000100007Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-09-10T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity |
title |
Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity |
spellingShingle |
Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity Lima,Tamires C. Asteraceae Calea pinnatifida Chromenes Leishmanicidal activity |
title_short |
Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity |
title_full |
Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity |
title_fullStr |
Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity |
title_full_unstemmed |
Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity |
title_sort |
Chromenes from leaves of Calea pinnatifida and evaluation of their leishmanicidal activity |
author |
Lima,Tamires C. |
author_facet |
Lima,Tamires C. Santos,Alan Diego C. Costa,Danielle T.M. Souza,Rafaela J. Barison,Andersson Steindel,Mário Biavatti,Maique W. |
author_role |
author |
author2 |
Santos,Alan Diego C. Costa,Danielle T.M. Souza,Rafaela J. Barison,Andersson Steindel,Mário Biavatti,Maique W. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lima,Tamires C. Santos,Alan Diego C. Costa,Danielle T.M. Souza,Rafaela J. Barison,Andersson Steindel,Mário Biavatti,Maique W. |
dc.subject.por.fl_str_mv |
Asteraceae Calea pinnatifida Chromenes Leishmanicidal activity |
topic |
Asteraceae Calea pinnatifida Chromenes Leishmanicidal activity |
description |
Calea pinnatifida (R. Br.) Less., Asteraceae, is popularly known as “quebra-tudo”, “cipó-cruz” or “aruca”. This species is used in the folk medicine for the treatment of stomach pain, giardiasis and amoebiasis. The aim of this study was to isolate and identify chromenes from leaves of C. pinnatifida and evaluate their leishmanicidal activity. A fraction from leaves of C. pinnatifida was analyzed for their chemical constituents, resulting in the isolation and characterization of four known chromenes: 6-acetyl-7-hydroxy-2,2-dimethylchromene (1), 6-acetyl-7-methoxy-2,2-dimethylchromene (2), 6-(1-hydroxyethyl)-7-methoxy-2,2-dimethylchromene (3) and 6-(1-ethoxyethyl)-7-methoxy-2,2-dimethylchromene (4). Structure identification of isolated compounds involved analysis of spectral data of 1D and 2D-NMR. The isolated compounds are here reported for the first time in C. pinnatifida, and the chromenes 1 and 3 show a moderate leishmanicidal activity. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000100007 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000100007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2015.01.004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.25 n.1 2015 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122469206982656 |