Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000600920 |
Resumo: | The present study was conducted to evaluate the toxicity of the ethanolic extract of leaves of Parkia platycephala Benth., Fabaceae, on systemic and reproductive parameters. In toxicity on the estrous cycle, four groups of not-pregnant Wistar rats received distilled water and the doses 250, 500 and 1000 mg.kg-1 of plant extract for thirty days, at the end of which they were examined as to the frequency of their phases. The systemic toxicity was assessed through the consumption of water and food and by measuring body mass. After the extract was administered, serum AST, ALT, ALP, bilirubin (total, direct and indirect), urea and creatinine were dosed. The evaluation of the organs (brain, heart, hypophysis, adrenal glands, liver, spleen, uterus and ovaries) in their macroscopic aspects, relative and absolute masses and histological structure showed that the plant extract induced a decrease of water and food consumption and of body mass. It caused an increase in the luteal phase and a decrease in the follicular phase of the estrous cycle and rose serum alkaline phosphatase levels.The data exhibit systemic and reproductive toxicity induced by plant extract in female Wistar rats. |
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Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar ratsParkia platycephalaSystemic toxicityReproductive toxicityEstrous cycleBiochemistry analysisHistopathologyThe present study was conducted to evaluate the toxicity of the ethanolic extract of leaves of Parkia platycephala Benth., Fabaceae, on systemic and reproductive parameters. In toxicity on the estrous cycle, four groups of not-pregnant Wistar rats received distilled water and the doses 250, 500 and 1000 mg.kg-1 of plant extract for thirty days, at the end of which they were examined as to the frequency of their phases. The systemic toxicity was assessed through the consumption of water and food and by measuring body mass. After the extract was administered, serum AST, ALT, ALP, bilirubin (total, direct and indirect), urea and creatinine were dosed. The evaluation of the organs (brain, heart, hypophysis, adrenal glands, liver, spleen, uterus and ovaries) in their macroscopic aspects, relative and absolute masses and histological structure showed that the plant extract induced a decrease of water and food consumption and of body mass. It caused an increase in the luteal phase and a decrease in the follicular phase of the estrous cycle and rose serum alkaline phosphatase levels.The data exhibit systemic and reproductive toxicity induced by plant extract in female Wistar rats.Sociedade Brasileira de Farmacognosia2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000600920Revista Brasileira de Farmacognosia v.23 n.6 2013reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2013000600009info:eu-repo/semantics/openAccessCosta,Bethânia A.Oliveira,Jamylla M.G. deSales,Paulo A.B.Lira,Silvéria R. de S.Silva,Silvana M.M. de S.Costa,Luciana M.Muratori,Maria C.S.Costa,Amilton P.R.eng2015-10-09T00:00:00Zoai:scielo:S0102-695X2013000600920Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-10-09T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar rats |
title |
Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar rats |
spellingShingle |
Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar rats Costa,Bethânia A. Parkia platycephala Systemic toxicity Reproductive toxicity Estrous cycle Biochemistry analysis Histopathology |
title_short |
Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar rats |
title_full |
Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar rats |
title_fullStr |
Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar rats |
title_full_unstemmed |
Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar rats |
title_sort |
Systemic and reproductive toxicity induced by Parkia platycephala ethanolic extract in female Wistar rats |
author |
Costa,Bethânia A. |
author_facet |
Costa,Bethânia A. Oliveira,Jamylla M.G. de Sales,Paulo A.B. Lira,Silvéria R. de S. Silva,Silvana M.M. de S. Costa,Luciana M. Muratori,Maria C.S. Costa,Amilton P.R. |
author_role |
author |
author2 |
Oliveira,Jamylla M.G. de Sales,Paulo A.B. Lira,Silvéria R. de S. Silva,Silvana M.M. de S. Costa,Luciana M. Muratori,Maria C.S. Costa,Amilton P.R. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa,Bethânia A. Oliveira,Jamylla M.G. de Sales,Paulo A.B. Lira,Silvéria R. de S. Silva,Silvana M.M. de S. Costa,Luciana M. Muratori,Maria C.S. Costa,Amilton P.R. |
dc.subject.por.fl_str_mv |
Parkia platycephala Systemic toxicity Reproductive toxicity Estrous cycle Biochemistry analysis Histopathology |
topic |
Parkia platycephala Systemic toxicity Reproductive toxicity Estrous cycle Biochemistry analysis Histopathology |
description |
The present study was conducted to evaluate the toxicity of the ethanolic extract of leaves of Parkia platycephala Benth., Fabaceae, on systemic and reproductive parameters. In toxicity on the estrous cycle, four groups of not-pregnant Wistar rats received distilled water and the doses 250, 500 and 1000 mg.kg-1 of plant extract for thirty days, at the end of which they were examined as to the frequency of their phases. The systemic toxicity was assessed through the consumption of water and food and by measuring body mass. After the extract was administered, serum AST, ALT, ALP, bilirubin (total, direct and indirect), urea and creatinine were dosed. The evaluation of the organs (brain, heart, hypophysis, adrenal glands, liver, spleen, uterus and ovaries) in their macroscopic aspects, relative and absolute masses and histological structure showed that the plant extract induced a decrease of water and food consumption and of body mass. It caused an increase in the luteal phase and a decrease in the follicular phase of the estrous cycle and rose serum alkaline phosphatase levels.The data exhibit systemic and reproductive toxicity induced by plant extract in female Wistar rats. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000600920 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000600920 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2013000600009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.23 n.6 2013 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122468435230720 |