Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500023 |
Resumo: | The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals. |
id |
SBFGNOSIA-1_107a04e958dc6b7b7ae56df03a3b418c |
---|---|
oai_identifier_str |
oai:scielo:S0102-695X2012000500023 |
network_acronym_str |
SBFGNOSIA-1 |
network_name_str |
Revista Brasileira de Farmacognosia (Online) |
repository_id_str |
|
spelling |
Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnicaacute toxicityBrazilian arnicahistopathological analysisLychnophora trichocarphaThe species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals.Sociedade Brasileira de Farmacognosia2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500023Revista Brasileira de Farmacognosia v.22 n.5 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000089info:eu-repo/semantics/openAccessFerrari,Fernanda C.Grabe-Guimarães,AndreaCarneiro,Cláudia M.Souza,Maíra R. deFerreira,Leidiane C.Oliveira,Tânia T. deSaúde-Guimarães,Dênia A.eng2012-09-18T00:00:00Zoai:scielo:S0102-695X2012000500023Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-09-18T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica |
title |
Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica |
spellingShingle |
Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica Ferrari,Fernanda C. acute toxicity Brazilian arnica histopathological analysis Lychnophora trichocarpha |
title_short |
Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica |
title_full |
Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica |
title_fullStr |
Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica |
title_full_unstemmed |
Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica |
title_sort |
Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica |
author |
Ferrari,Fernanda C. |
author_facet |
Ferrari,Fernanda C. Grabe-Guimarães,Andrea Carneiro,Cláudia M. Souza,Maíra R. de Ferreira,Leidiane C. Oliveira,Tânia T. de Saúde-Guimarães,Dênia A. |
author_role |
author |
author2 |
Grabe-Guimarães,Andrea Carneiro,Cláudia M. Souza,Maíra R. de Ferreira,Leidiane C. Oliveira,Tânia T. de Saúde-Guimarães,Dênia A. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Ferrari,Fernanda C. Grabe-Guimarães,Andrea Carneiro,Cláudia M. Souza,Maíra R. de Ferreira,Leidiane C. Oliveira,Tânia T. de Saúde-Guimarães,Dênia A. |
dc.subject.por.fl_str_mv |
acute toxicity Brazilian arnica histopathological analysis Lychnophora trichocarpha |
topic |
acute toxicity Brazilian arnica histopathological analysis Lychnophora trichocarpha |
description |
The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500023 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500023 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2012005000089 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.22 n.5 2012 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122467834396672 |