Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica

Detalhes bibliográficos
Autor(a) principal: Ferrari,Fernanda C.
Data de Publicação: 2012
Outros Autores: Grabe-Guimarães,Andrea, Carneiro,Cláudia M., Souza,Maíra R. de, Ferreira,Leidiane C., Oliveira,Tânia T. de, Saúde-Guimarães,Dênia A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500023
Resumo: The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals.
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spelling Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnicaacute toxicityBrazilian arnicahistopathological analysisLychnophora trichocarphaThe species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals.Sociedade Brasileira de Farmacognosia2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500023Revista Brasileira de Farmacognosia v.22 n.5 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000089info:eu-repo/semantics/openAccessFerrari,Fernanda C.Grabe-Guimarães,AndreaCarneiro,Cláudia M.Souza,Maíra R. deFerreira,Leidiane C.Oliveira,Tânia T. deSaúde-Guimarães,Dênia A.eng2012-09-18T00:00:00Zoai:scielo:S0102-695X2012000500023Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-09-18T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
title Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
spellingShingle Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
Ferrari,Fernanda C.
acute toxicity
Brazilian arnica
histopathological analysis
Lychnophora trichocarpha
title_short Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
title_full Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
title_fullStr Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
title_full_unstemmed Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
title_sort Toxicological evaluation of ethanolic extract of Lychnophora trichocarpha, Brazilian arnica
author Ferrari,Fernanda C.
author_facet Ferrari,Fernanda C.
Grabe-Guimarães,Andrea
Carneiro,Cláudia M.
Souza,Maíra R. de
Ferreira,Leidiane C.
Oliveira,Tânia T. de
Saúde-Guimarães,Dênia A.
author_role author
author2 Grabe-Guimarães,Andrea
Carneiro,Cláudia M.
Souza,Maíra R. de
Ferreira,Leidiane C.
Oliveira,Tânia T. de
Saúde-Guimarães,Dênia A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferrari,Fernanda C.
Grabe-Guimarães,Andrea
Carneiro,Cláudia M.
Souza,Maíra R. de
Ferreira,Leidiane C.
Oliveira,Tânia T. de
Saúde-Guimarães,Dênia A.
dc.subject.por.fl_str_mv acute toxicity
Brazilian arnica
histopathological analysis
Lychnophora trichocarpha
topic acute toxicity
Brazilian arnica
histopathological analysis
Lychnophora trichocarpha
description The species of the genus Lychnophora, Asteraceae, are popularly known as "arnica" and are native from Brazilian savana (Cerrado). They are widely used in Brazilian folk medicine as anti-inflammatory, to treat bruise, pain, rheumatism and for insect bites. For evaluation of acute toxicity, the ethanolic extract was given to albino female and male mice. In open-field test, the extract of Lychnophora trichocarpha (Spreng.) Spreng. (0.750 g/kg) induced a significant inhibition of the spontaneous locomotor activity and exploratory behavior of the animals were observed 1 and 4 h after administration. In traction test, the same dose reduced the muscular force 1 h after administration. The exploratory behavior reduced significantly in the group that received 0.50 g/kg, 1 and 4 h after administration of the extract. The animals that received the doses of 0.25, 0.50 and 0.75 g/kg did not show any change of blood biochemical parameters comparing to control group and showed some histopathological changes such as congestion and inflammation of kidney and liver. The dose of 1.5 g/kg caused the most serious signs of toxicity. Histopathological changes observed was hemorrhage in 62.5% and pulmonary congestion in 100% of the animals. Brain and liver congestion was found in 62.5% of the animals.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500023
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2012005000089
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.5 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
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instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
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reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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