Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2014000300341 |
Resumo: | The extraction of plant constituents is essential to isolate biologically active compounds, aimed to understand their role on the treatment of diabetes. This study was designed to explore the preliminary phytochemical and physicochemical analysis of Carica papaya L., Caricaceae, leaf, and further evaluation of its hypoglycemic effect on diabetic rats. C. papaya leaves were extracted using chloroform, n-hexane or ethanol. For each extract a phytochemical screening was performed. The tests were conducted in triplicate and the qualitative and quantitative determination of the various metabolites was done using analytical standards proposed by Mexican Herbal Pharmacopoeia. The chloroform extract, containing steroids and quinones as major components, was chosen to study C. papaya biological effects. The chloroform extract was evaporated to dryness, and doses 0, 31, 62, 125 mg/kg were orally administered in 300 µl polyethylene glycol to diabetic rats; and 0 and 62 mg/kg to non-diabetic rats. After a 20-day treatment with the chloroform extract, the animals were sacrificed and blood was obtained for biochemical studies. The main effect observed was a decrease in serum glucose, triglycerides and transaminases in diabetic rats after the administration of C. papaya chloroform extract. These results confirm the potential beneficial action of C. papaya to treat the symptoms of diabetic patients. |
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Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic ratsCarica papayaDiabetesStreptozotocinSteroidsTanninsQuinonesAlkaloidsThe extraction of plant constituents is essential to isolate biologically active compounds, aimed to understand their role on the treatment of diabetes. This study was designed to explore the preliminary phytochemical and physicochemical analysis of Carica papaya L., Caricaceae, leaf, and further evaluation of its hypoglycemic effect on diabetic rats. C. papaya leaves were extracted using chloroform, n-hexane or ethanol. For each extract a phytochemical screening was performed. The tests were conducted in triplicate and the qualitative and quantitative determination of the various metabolites was done using analytical standards proposed by Mexican Herbal Pharmacopoeia. The chloroform extract, containing steroids and quinones as major components, was chosen to study C. papaya biological effects. The chloroform extract was evaporated to dryness, and doses 0, 31, 62, 125 mg/kg were orally administered in 300 µl polyethylene glycol to diabetic rats; and 0 and 62 mg/kg to non-diabetic rats. After a 20-day treatment with the chloroform extract, the animals were sacrificed and blood was obtained for biochemical studies. The main effect observed was a decrease in serum glucose, triglycerides and transaminases in diabetic rats after the administration of C. papaya chloroform extract. These results confirm the potential beneficial action of C. papaya to treat the symptoms of diabetic patients.Sociedade Brasileira de Farmacognosia2014-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2014000300341Revista Brasileira de Farmacognosia v.24 n.3 2014reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2014.07.012info:eu-repo/semantics/openAccessJuárez-Rojop,Isela E.A.Tovilla-Zárate,CarlosAguilar-Domínguez,Dora E.Fuente,Luis F. Roa-de laLobato-García,Carlos E.Blé-Castillo,Jorge L.López-Meraz,LeonorDíaz-Zagoya,Juan C.Bermúdez-Ocaña,Deysi Y.eng2015-08-28T00:00:00Zoai:scielo:S0102-695X2014000300341Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-08-28T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats |
title |
Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats |
spellingShingle |
Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats Juárez-Rojop,Isela E. Carica papaya Diabetes Streptozotocin Steroids Tannins Quinones Alkaloids |
title_short |
Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats |
title_full |
Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats |
title_fullStr |
Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats |
title_full_unstemmed |
Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats |
title_sort |
Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats |
author |
Juárez-Rojop,Isela E. |
author_facet |
Juárez-Rojop,Isela E. A.Tovilla-Zárate,Carlos Aguilar-Domínguez,Dora E. Fuente,Luis F. Roa-de la Lobato-García,Carlos E. Blé-Castillo,Jorge L. López-Meraz,Leonor Díaz-Zagoya,Juan C. Bermúdez-Ocaña,Deysi Y. |
author_role |
author |
author2 |
A.Tovilla-Zárate,Carlos Aguilar-Domínguez,Dora E. Fuente,Luis F. Roa-de la Lobato-García,Carlos E. Blé-Castillo,Jorge L. López-Meraz,Leonor Díaz-Zagoya,Juan C. Bermúdez-Ocaña,Deysi Y. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Juárez-Rojop,Isela E. A.Tovilla-Zárate,Carlos Aguilar-Domínguez,Dora E. Fuente,Luis F. Roa-de la Lobato-García,Carlos E. Blé-Castillo,Jorge L. López-Meraz,Leonor Díaz-Zagoya,Juan C. Bermúdez-Ocaña,Deysi Y. |
dc.subject.por.fl_str_mv |
Carica papaya Diabetes Streptozotocin Steroids Tannins Quinones Alkaloids |
topic |
Carica papaya Diabetes Streptozotocin Steroids Tannins Quinones Alkaloids |
description |
The extraction of plant constituents is essential to isolate biologically active compounds, aimed to understand their role on the treatment of diabetes. This study was designed to explore the preliminary phytochemical and physicochemical analysis of Carica papaya L., Caricaceae, leaf, and further evaluation of its hypoglycemic effect on diabetic rats. C. papaya leaves were extracted using chloroform, n-hexane or ethanol. For each extract a phytochemical screening was performed. The tests were conducted in triplicate and the qualitative and quantitative determination of the various metabolites was done using analytical standards proposed by Mexican Herbal Pharmacopoeia. The chloroform extract, containing steroids and quinones as major components, was chosen to study C. papaya biological effects. The chloroform extract was evaporated to dryness, and doses 0, 31, 62, 125 mg/kg were orally administered in 300 µl polyethylene glycol to diabetic rats; and 0 and 62 mg/kg to non-diabetic rats. After a 20-day treatment with the chloroform extract, the animals were sacrificed and blood was obtained for biochemical studies. The main effect observed was a decrease in serum glucose, triglycerides and transaminases in diabetic rats after the administration of C. papaya chloroform extract. These results confirm the potential beneficial action of C. papaya to treat the symptoms of diabetic patients. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2014000300341 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2014000300341 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2014.07.012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.24 n.3 2014 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122469132533760 |