Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica

Detalhes bibliográficos
Autor(a) principal: El-Desouky,Samy K.
Data de Publicação: 2018
Outros Autores: Hawas,Usama W., Khemira,Habib, Kim,Young-Kyoon
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000500564
Resumo: Abstract The chemical investigation of the n-hexane fraction of Salvadora persica L., Salvadoraceae, seeds afforded a new stearic acid ester, salvastearolide, together with five other phytosteroids identified as stigmasterol, β-sitosterol, Δ7-campesterol, Δ7-avenasterol and campesterol. Their structures were established on the basis of extensive spectroscopic methods including 1D and 2D NMR experiments and HRESI mass spectrometry. In addition, salvastearolide and the isolated fractions were tested for their cytotoxicity against human cancer cell lines MCF-7, MDA-MB-231 and HT-29. The n-hexane fraction exhibited significant anti-proliferative effect against human breast cancer cell line MCF-7 (IC50 50 µg/ml), while salvastearolide possessed a weak cytotoxic effect against MCF-7 cells with IC50 103.98 µg/ml.
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spelling Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persicaSalvastearolidePhytosteroidsNMRCytotoxic activitiesAbstract The chemical investigation of the n-hexane fraction of Salvadora persica L., Salvadoraceae, seeds afforded a new stearic acid ester, salvastearolide, together with five other phytosteroids identified as stigmasterol, β-sitosterol, Δ7-campesterol, Δ7-avenasterol and campesterol. Their structures were established on the basis of extensive spectroscopic methods including 1D and 2D NMR experiments and HRESI mass spectrometry. In addition, salvastearolide and the isolated fractions were tested for their cytotoxicity against human cancer cell lines MCF-7, MDA-MB-231 and HT-29. The n-hexane fraction exhibited significant anti-proliferative effect against human breast cancer cell line MCF-7 (IC50 50 µg/ml), while salvastearolide possessed a weak cytotoxic effect against MCF-7 cells with IC50 103.98 µg/ml.Sociedade Brasileira de Farmacognosia2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000500564Revista Brasileira de Farmacognosia v.28 n.5 2018reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2018.05.013info:eu-repo/semantics/openAccessEl-Desouky,Samy K.Hawas,Usama W.Khemira,HabibKim,Young-Kyooneng2018-10-09T00:00:00Zoai:scielo:S0102-695X2018000500564Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2018-10-09T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
title Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
spellingShingle Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
El-Desouky,Samy K.
Salvastearolide
Phytosteroids
NMR
Cytotoxic activities
title_short Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
title_full Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
title_fullStr Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
title_full_unstemmed Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
title_sort Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
author El-Desouky,Samy K.
author_facet El-Desouky,Samy K.
Hawas,Usama W.
Khemira,Habib
Kim,Young-Kyoon
author_role author
author2 Hawas,Usama W.
Khemira,Habib
Kim,Young-Kyoon
author2_role author
author
author
dc.contributor.author.fl_str_mv El-Desouky,Samy K.
Hawas,Usama W.
Khemira,Habib
Kim,Young-Kyoon
dc.subject.por.fl_str_mv Salvastearolide
Phytosteroids
NMR
Cytotoxic activities
topic Salvastearolide
Phytosteroids
NMR
Cytotoxic activities
description Abstract The chemical investigation of the n-hexane fraction of Salvadora persica L., Salvadoraceae, seeds afforded a new stearic acid ester, salvastearolide, together with five other phytosteroids identified as stigmasterol, β-sitosterol, Δ7-campesterol, Δ7-avenasterol and campesterol. Their structures were established on the basis of extensive spectroscopic methods including 1D and 2D NMR experiments and HRESI mass spectrometry. In addition, salvastearolide and the isolated fractions were tested for their cytotoxicity against human cancer cell lines MCF-7, MDA-MB-231 and HT-29. The n-hexane fraction exhibited significant anti-proliferative effect against human breast cancer cell line MCF-7 (IC50 50 µg/ml), while salvastearolide possessed a weak cytotoxic effect against MCF-7 cells with IC50 103.98 µg/ml.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000500564
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2018000500564
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2018.05.013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.28 n.5 2018
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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