Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae

Detalhes bibliográficos
Autor(a) principal: Freire,Vítor F.
Data de Publicação: 2019
Outros Autores: Slivinski,Juliano, Quintana-Bulla,Jairo I., Moraes,Fernando C., Paradas,Wladimir C., Salgado,Leonardo T., Pereira,Renato C., Moura,Rodrigo L., Amado-Filho,Gilberto M., Ferreira,Antonio G., Berlinck,Roberto G.S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600715
Resumo: ABSTRACT Chemical investigation of the aqueous fraction of the ethanol extract from the Brazilian endemic marine sponge Clathria (Clathria) nicoleae Vieira de Barros, Santos & Pinheiro, 2013, Microcionidae, sampled from a 55 m deep rhodolith bed at the Amazon River mouth, led to the isolation of a new hexapeptide, clathriamide (1). HP-20 resin was used to capture compound 1 from the aqueous fraction, which was purified by additional chromatographic steps. The absolute configuration of the amino acids of 1 was determined by advanced Marfey's analysis using 5-fluoro-2,4-dinitrophenyl-Nα-L-tryptophanamide. The amino acid derivatives analyzed by ultra-performance liquid chromatography coupled to a mass spectrometry using a C8 column enabled a good chromatographic resolution of L-Ile and L-allo-Ile, previously unfeasible using C18 column.
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spelling Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleaePoriferaPeptideAdvanced marfey's analysisRhodolith bedAqueous extractABSTRACT Chemical investigation of the aqueous fraction of the ethanol extract from the Brazilian endemic marine sponge Clathria (Clathria) nicoleae Vieira de Barros, Santos & Pinheiro, 2013, Microcionidae, sampled from a 55 m deep rhodolith bed at the Amazon River mouth, led to the isolation of a new hexapeptide, clathriamide (1). HP-20 resin was used to capture compound 1 from the aqueous fraction, which was purified by additional chromatographic steps. The absolute configuration of the amino acids of 1 was determined by advanced Marfey's analysis using 5-fluoro-2,4-dinitrophenyl-Nα-L-tryptophanamide. The amino acid derivatives analyzed by ultra-performance liquid chromatography coupled to a mass spectrometry using a C8 column enabled a good chromatographic resolution of L-Ile and L-allo-Ile, previously unfeasible using C18 column.Sociedade Brasileira de Farmacognosia2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600715Revista Brasileira de Farmacognosia v.29 n.6 2019reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2019.07.001info:eu-repo/semantics/openAccessFreire,Vítor F.Slivinski,JulianoQuintana-Bulla,Jairo I.Moraes,Fernando C.Paradas,Wladimir C.Salgado,Leonardo T.Pereira,Renato C.Moura,Rodrigo L.Amado-Filho,Gilberto M.Ferreira,Antonio G.Berlinck,Roberto G.S.eng2020-01-30T00:00:00Zoai:scielo:S0102-695X2019000600715Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2020-01-30T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae
title Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae
spellingShingle Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae
Freire,Vítor F.
Porifera
Peptide
Advanced marfey's analysis
Rhodolith bed
Aqueous extract
title_short Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae
title_full Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae
title_fullStr Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae
title_full_unstemmed Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae
title_sort Clathriamide, an hexapeptide isolated from the marine sponge Clathria (Clathria) nicoleae
author Freire,Vítor F.
author_facet Freire,Vítor F.
Slivinski,Juliano
Quintana-Bulla,Jairo I.
Moraes,Fernando C.
Paradas,Wladimir C.
Salgado,Leonardo T.
Pereira,Renato C.
Moura,Rodrigo L.
Amado-Filho,Gilberto M.
Ferreira,Antonio G.
Berlinck,Roberto G.S.
author_role author
author2 Slivinski,Juliano
Quintana-Bulla,Jairo I.
Moraes,Fernando C.
Paradas,Wladimir C.
Salgado,Leonardo T.
Pereira,Renato C.
Moura,Rodrigo L.
Amado-Filho,Gilberto M.
Ferreira,Antonio G.
Berlinck,Roberto G.S.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freire,Vítor F.
Slivinski,Juliano
Quintana-Bulla,Jairo I.
Moraes,Fernando C.
Paradas,Wladimir C.
Salgado,Leonardo T.
Pereira,Renato C.
Moura,Rodrigo L.
Amado-Filho,Gilberto M.
Ferreira,Antonio G.
Berlinck,Roberto G.S.
dc.subject.por.fl_str_mv Porifera
Peptide
Advanced marfey's analysis
Rhodolith bed
Aqueous extract
topic Porifera
Peptide
Advanced marfey's analysis
Rhodolith bed
Aqueous extract
description ABSTRACT Chemical investigation of the aqueous fraction of the ethanol extract from the Brazilian endemic marine sponge Clathria (Clathria) nicoleae Vieira de Barros, Santos & Pinheiro, 2013, Microcionidae, sampled from a 55 m deep rhodolith bed at the Amazon River mouth, led to the isolation of a new hexapeptide, clathriamide (1). HP-20 resin was used to capture compound 1 from the aqueous fraction, which was purified by additional chromatographic steps. The absolute configuration of the amino acids of 1 was determined by advanced Marfey's analysis using 5-fluoro-2,4-dinitrophenyl-Nα-L-tryptophanamide. The amino acid derivatives analyzed by ultra-performance liquid chromatography coupled to a mass spectrometry using a C8 column enabled a good chromatographic resolution of L-Ile and L-allo-Ile, previously unfeasible using C18 column.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600715
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000600715
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2019.07.001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.29 n.6 2019
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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