Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600751 |
Resumo: | ABSTRACT The essential oil from Croton polyandrus Spreng., Euphorbiaceae, leaves was tested for the toxicity and antitumor activity. The concentration producing 50% hemolysis was 141 µg/ml on mice erythrocytes. In the acute toxicological study, the estimated LD50 was 447.18 mg/kg. The essential oil did not induce increase in number of micronucleated erythrocytes, suggesting low genotoxicity. Essential oil (100 or 150 mg/kg) showed significant antitumor activity in Ehrlich ascitic carcinoma model. We observed that essential oil induces cell-cycle arrest at the G0/G1 phase, and increases the sub-G1 peak, which represents a marker of cell death by apoptosis. Survival also increased for the treated animals. The toxicological analyses revealed reduction in body weight, increased aspartate aminotransferase and alanine aminotransferase activity, hematological changes, and a thymus index reduction. These data suggest gastrointestinal and liver toxicity, anemia, leukopenia/lymphocytopenia, and immunosuppressive effects. Histopathological analysis revealed the weak hepatotoxicity of essential oil. In summary, essential oil of C. polyandrus displays in vivo antitumor activity and moderate toxicity. |
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Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cellsAntitumor activityCroton polyandrousEhrlich ascites carcinomaEssential oilGenotoxicityToxicityABSTRACT The essential oil from Croton polyandrus Spreng., Euphorbiaceae, leaves was tested for the toxicity and antitumor activity. The concentration producing 50% hemolysis was 141 µg/ml on mice erythrocytes. In the acute toxicological study, the estimated LD50 was 447.18 mg/kg. The essential oil did not induce increase in number of micronucleated erythrocytes, suggesting low genotoxicity. Essential oil (100 or 150 mg/kg) showed significant antitumor activity in Ehrlich ascitic carcinoma model. We observed that essential oil induces cell-cycle arrest at the G0/G1 phase, and increases the sub-G1 peak, which represents a marker of cell death by apoptosis. Survival also increased for the treated animals. The toxicological analyses revealed reduction in body weight, increased aspartate aminotransferase and alanine aminotransferase activity, hematological changes, and a thymus index reduction. These data suggest gastrointestinal and liver toxicity, anemia, leukopenia/lymphocytopenia, and immunosuppressive effects. Histopathological analysis revealed the weak hepatotoxicity of essential oil. In summary, essential oil of C. polyandrus displays in vivo antitumor activity and moderate toxicity.Sociedade Brasileira de Farmacognosia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600751Revista Brasileira de Farmacognosia v.26 n.6 2016reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2016.05.014info:eu-repo/semantics/openAccessMeireles,Déborah R.P.Fernandes,Heloísa M.B.Rolim,Thaísa L.Batista,Tatianne M.Mangueira,Vivianne M.Sousa,Tatyanna K.G. dePita,João C.L.R.Xavier,Aline L.Beltrão,Daiene M.Tavares,Josean F.Silva,Marcelo S.Medeiros,Karina K.P.Sobral,Marianna V.eng2016-12-05T00:00:00Zoai:scielo:S0102-695X2016000600751Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2016-12-05T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells |
title |
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells |
spellingShingle |
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells Meireles,Déborah R.P. Antitumor activity Croton polyandrous Ehrlich ascites carcinoma Essential oil Genotoxicity Toxicity |
title_short |
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells |
title_full |
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells |
title_fullStr |
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells |
title_full_unstemmed |
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells |
title_sort |
Toxicity and antitumor efficacy of Croton polyandrus oil against Ehrlich ascites carcinoma cells |
author |
Meireles,Déborah R.P. |
author_facet |
Meireles,Déborah R.P. Fernandes,Heloísa M.B. Rolim,Thaísa L. Batista,Tatianne M. Mangueira,Vivianne M. Sousa,Tatyanna K.G. de Pita,João C.L.R. Xavier,Aline L. Beltrão,Daiene M. Tavares,Josean F. Silva,Marcelo S. Medeiros,Karina K.P. Sobral,Marianna V. |
author_role |
author |
author2 |
Fernandes,Heloísa M.B. Rolim,Thaísa L. Batista,Tatianne M. Mangueira,Vivianne M. Sousa,Tatyanna K.G. de Pita,João C.L.R. Xavier,Aline L. Beltrão,Daiene M. Tavares,Josean F. Silva,Marcelo S. Medeiros,Karina K.P. Sobral,Marianna V. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Meireles,Déborah R.P. Fernandes,Heloísa M.B. Rolim,Thaísa L. Batista,Tatianne M. Mangueira,Vivianne M. Sousa,Tatyanna K.G. de Pita,João C.L.R. Xavier,Aline L. Beltrão,Daiene M. Tavares,Josean F. Silva,Marcelo S. Medeiros,Karina K.P. Sobral,Marianna V. |
dc.subject.por.fl_str_mv |
Antitumor activity Croton polyandrous Ehrlich ascites carcinoma Essential oil Genotoxicity Toxicity |
topic |
Antitumor activity Croton polyandrous Ehrlich ascites carcinoma Essential oil Genotoxicity Toxicity |
description |
ABSTRACT The essential oil from Croton polyandrus Spreng., Euphorbiaceae, leaves was tested for the toxicity and antitumor activity. The concentration producing 50% hemolysis was 141 µg/ml on mice erythrocytes. In the acute toxicological study, the estimated LD50 was 447.18 mg/kg. The essential oil did not induce increase in number of micronucleated erythrocytes, suggesting low genotoxicity. Essential oil (100 or 150 mg/kg) showed significant antitumor activity in Ehrlich ascitic carcinoma model. We observed that essential oil induces cell-cycle arrest at the G0/G1 phase, and increases the sub-G1 peak, which represents a marker of cell death by apoptosis. Survival also increased for the treated animals. The toxicological analyses revealed reduction in body weight, increased aspartate aminotransferase and alanine aminotransferase activity, hematological changes, and a thymus index reduction. These data suggest gastrointestinal and liver toxicity, anemia, leukopenia/lymphocytopenia, and immunosuppressive effects. Histopathological analysis revealed the weak hepatotoxicity of essential oil. In summary, essential oil of C. polyandrus displays in vivo antitumor activity and moderate toxicity. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600751 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600751 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2016.05.014 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.26 n.6 2016 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122470129729536 |