Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect

Detalhes bibliográficos
Autor(a) principal: Marques,Cybelle Teixeira
Data de Publicação: 2012
Outros Autores: Azevedo,Tarciana C. G. de, Nascimento,Marília S., Medeiros,Valquíria P., Alves,Luciana G., Benevides,Norma M. B., Rocha,Hugo A. O., Leite,Edda Lisboa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100017
Resumo: Sulfated polysaccharides were extracted with acetone from brown algae Padina gymnospora. The fraction precipitated with 1.5 volumes of acetone (F1.5) purified in Sephadex G-75 was characterized by infrared and nuclear magnetic resonance of 13C and ¹H, through which the presence of sulfate groups on the C4 of α-L-fucose could be observed. This polysaccharide showed that an MW of 25,000 Da was effective in reducing leukocyte influx into the peritoneal cavity in mice at 10 mg/kg and 25 mg/kg body weight, causing a decrease of 60 and 39%, respectively. In the present study, it was observed that this fucan has anti-inflammatory properties but no cytotoxic action, indicating its potential use in the pharmaceutical industry.
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spelling Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effectalgaeassessment anti-inflammatoryfucansnitric oxidePadina gymnosporasulfated polysaccharidesSulfated polysaccharides were extracted with acetone from brown algae Padina gymnospora. The fraction precipitated with 1.5 volumes of acetone (F1.5) purified in Sephadex G-75 was characterized by infrared and nuclear magnetic resonance of 13C and ¹H, through which the presence of sulfate groups on the C4 of α-L-fucose could be observed. This polysaccharide showed that an MW of 25,000 Da was effective in reducing leukocyte influx into the peritoneal cavity in mice at 10 mg/kg and 25 mg/kg body weight, causing a decrease of 60 and 39%, respectively. In the present study, it was observed that this fucan has anti-inflammatory properties but no cytotoxic action, indicating its potential use in the pharmaceutical industry.Sociedade Brasileira de Farmacognosia2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100017Revista Brasileira de Farmacognosia v.22 n.1 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000206info:eu-repo/semantics/openAccessMarques,Cybelle TeixeiraAzevedo,Tarciana C. G. deNascimento,Marília S.Medeiros,Valquíria P.Alves,Luciana G.Benevides,Norma M. B.Rocha,Hugo A. O.Leite,Edda Lisboaeng2011-12-06T00:00:00Zoai:scielo:S0102-695X2012000100017Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-12-06T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect
title Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect
spellingShingle Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect
Marques,Cybelle Teixeira
algae
assessment anti-inflammatory
fucans
nitric oxide
Padina gymnospora
sulfated polysaccharides
title_short Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect
title_full Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect
title_fullStr Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect
title_full_unstemmed Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect
title_sort Sulfated fucans extracted from algae Padina gymnospora have anti-inflammatory effect
author Marques,Cybelle Teixeira
author_facet Marques,Cybelle Teixeira
Azevedo,Tarciana C. G. de
Nascimento,Marília S.
Medeiros,Valquíria P.
Alves,Luciana G.
Benevides,Norma M. B.
Rocha,Hugo A. O.
Leite,Edda Lisboa
author_role author
author2 Azevedo,Tarciana C. G. de
Nascimento,Marília S.
Medeiros,Valquíria P.
Alves,Luciana G.
Benevides,Norma M. B.
Rocha,Hugo A. O.
Leite,Edda Lisboa
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Marques,Cybelle Teixeira
Azevedo,Tarciana C. G. de
Nascimento,Marília S.
Medeiros,Valquíria P.
Alves,Luciana G.
Benevides,Norma M. B.
Rocha,Hugo A. O.
Leite,Edda Lisboa
dc.subject.por.fl_str_mv algae
assessment anti-inflammatory
fucans
nitric oxide
Padina gymnospora
sulfated polysaccharides
topic algae
assessment anti-inflammatory
fucans
nitric oxide
Padina gymnospora
sulfated polysaccharides
description Sulfated polysaccharides were extracted with acetone from brown algae Padina gymnospora. The fraction precipitated with 1.5 volumes of acetone (F1.5) purified in Sephadex G-75 was characterized by infrared and nuclear magnetic resonance of 13C and ¹H, through which the presence of sulfate groups on the C4 of α-L-fucose could be observed. This polysaccharide showed that an MW of 25,000 Da was effective in reducing leukocyte influx into the peritoneal cavity in mice at 10 mg/kg and 25 mg/kg body weight, causing a decrease of 60 and 39%, respectively. In the present study, it was observed that this fucan has anti-inflammatory properties but no cytotoxic action, indicating its potential use in the pharmaceutical industry.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100017
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000100017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000206
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.1 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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