HIV-1 Reverse Transcriptase: a potential target for marine products
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000400025 |
Resumo: | HIV-1 reverse transcriptase (HIV-1 RT) is a therapeutic target for the treatment of HIV-positive individuals or those already showing AIDS symptoms. In this perspective, the identification of new inhibitors for this enzyme is of great importance in view of the growing viral resistance to the existing treatments. This resistance has compromised the quality of life of those infected with multidrug-resistant strains, whose treatment options are already limited, putting at risk these individuals lives. The literature has recognized marine organisms and their products as natural sources for the identification of new therapeutic options for different pathologies. In this brief review, we consider the structure of HIV-1 RT and its most common inhibitors, as well as some marine diterpenes originally reported as HIV-1 RT inhibitors to encourage the identification and development of new marine antiviral prototypes. |
id |
SBFGNOSIA-1_47c9c6cb8e6cbb758209feab364087e4 |
---|---|
oai_identifier_str |
oai:scielo:S0102-695X2012000400025 |
network_acronym_str |
SBFGNOSIA-1 |
network_name_str |
Revista Brasileira de Farmacognosia (Online) |
repository_id_str |
|
spelling |
HIV-1 Reverse Transcriptase: a potential target for marine productsbrown algaediterpenesHIVinhibitornatural productsreverse transcriptaseHIV-1 reverse transcriptase (HIV-1 RT) is a therapeutic target for the treatment of HIV-positive individuals or those already showing AIDS symptoms. In this perspective, the identification of new inhibitors for this enzyme is of great importance in view of the growing viral resistance to the existing treatments. This resistance has compromised the quality of life of those infected with multidrug-resistant strains, whose treatment options are already limited, putting at risk these individuals lives. The literature has recognized marine organisms and their products as natural sources for the identification of new therapeutic options for different pathologies. In this brief review, we consider the structure of HIV-1 RT and its most common inhibitors, as well as some marine diterpenes originally reported as HIV-1 RT inhibitors to encourage the identification and development of new marine antiviral prototypes.Sociedade Brasileira de Farmacognosia2012-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000400025Revista Brasileira de Farmacognosia v.22 n.4 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000084info:eu-repo/semantics/openAccessMiceli,Leonardo A.Souza,Alessandra M. T. deRodrigues,Carlos R.Paixão,Izabel C. N. P.Teixeira,Valéria L.Castro,Helena C.eng2012-06-27T00:00:00Zoai:scielo:S0102-695X2012000400025Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-06-27T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
HIV-1 Reverse Transcriptase: a potential target for marine products |
title |
HIV-1 Reverse Transcriptase: a potential target for marine products |
spellingShingle |
HIV-1 Reverse Transcriptase: a potential target for marine products Miceli,Leonardo A. brown algae diterpenes HIV inhibitor natural products reverse transcriptase |
title_short |
HIV-1 Reverse Transcriptase: a potential target for marine products |
title_full |
HIV-1 Reverse Transcriptase: a potential target for marine products |
title_fullStr |
HIV-1 Reverse Transcriptase: a potential target for marine products |
title_full_unstemmed |
HIV-1 Reverse Transcriptase: a potential target for marine products |
title_sort |
HIV-1 Reverse Transcriptase: a potential target for marine products |
author |
Miceli,Leonardo A. |
author_facet |
Miceli,Leonardo A. Souza,Alessandra M. T. de Rodrigues,Carlos R. Paixão,Izabel C. N. P. Teixeira,Valéria L. Castro,Helena C. |
author_role |
author |
author2 |
Souza,Alessandra M. T. de Rodrigues,Carlos R. Paixão,Izabel C. N. P. Teixeira,Valéria L. Castro,Helena C. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Miceli,Leonardo A. Souza,Alessandra M. T. de Rodrigues,Carlos R. Paixão,Izabel C. N. P. Teixeira,Valéria L. Castro,Helena C. |
dc.subject.por.fl_str_mv |
brown algae diterpenes HIV inhibitor natural products reverse transcriptase |
topic |
brown algae diterpenes HIV inhibitor natural products reverse transcriptase |
description |
HIV-1 reverse transcriptase (HIV-1 RT) is a therapeutic target for the treatment of HIV-positive individuals or those already showing AIDS symptoms. In this perspective, the identification of new inhibitors for this enzyme is of great importance in view of the growing viral resistance to the existing treatments. This resistance has compromised the quality of life of those infected with multidrug-resistant strains, whose treatment options are already limited, putting at risk these individuals lives. The literature has recognized marine organisms and their products as natural sources for the identification of new therapeutic options for different pathologies. In this brief review, we consider the structure of HIV-1 RT and its most common inhibitors, as well as some marine diterpenes originally reported as HIV-1 RT inhibitors to encourage the identification and development of new marine antiviral prototypes. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000400025 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000400025 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2012005000084 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.22 n.4 2012 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122467824959488 |