Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600651 |
Resumo: | Abstract Chagas' disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affect millions of people worldwide. The available drugs for treatment of this infection cause serious side effects and have variable efficacy, especially in the chronic phase of the disease. In this context, natural compounds have shown great potential for the discovery of new chemotherapies for the treatment of this infection and various other diseases. In present study, we evaluated the in vitro antiprotozoal activity of five species of Brazilian and Spanish marine sponges (Condrosia reniformes, Tethya rubra, Tethya ignis, Mycale angulosa and Dysidea avara) against T. cruzi. By GC–MS data, we observed that in these extracts were present the major classes of the following compounds: hydrocarbons, terpenes, steroids and alcohols. The extracts showed activity against the three forms of this parasite and did not induce toxicity in mammalian cells. Better activities were observed with the extracts of marine sponges, C. reniformes (EC50 = 0.6 μg/ml), D. avara (EC50 = 1.1 μg/ml) and M. angulosa (EC50 = 3.8 μg/ml), against trypomastigote forms. In intracellular amastigote forms, the extract of T. ignis showed IC50 of 7.2 μg/ml and SI of 24.65. On this basis, our results indicate that these extracts can be promising chemotherapeutic agents against T. cruzi. |
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Trypanocidal activity of organic extracts from the Brazilian and Spanish marine spongesChagas’ diseaseTrypanosoma cruziNatural productsMarine spongesAbstract Chagas' disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affect millions of people worldwide. The available drugs for treatment of this infection cause serious side effects and have variable efficacy, especially in the chronic phase of the disease. In this context, natural compounds have shown great potential for the discovery of new chemotherapies for the treatment of this infection and various other diseases. In present study, we evaluated the in vitro antiprotozoal activity of five species of Brazilian and Spanish marine sponges (Condrosia reniformes, Tethya rubra, Tethya ignis, Mycale angulosa and Dysidea avara) against T. cruzi. By GC–MS data, we observed that in these extracts were present the major classes of the following compounds: hydrocarbons, terpenes, steroids and alcohols. The extracts showed activity against the three forms of this parasite and did not induce toxicity in mammalian cells. Better activities were observed with the extracts of marine sponges, C. reniformes (EC50 = 0.6 μg/ml), D. avara (EC50 = 1.1 μg/ml) and M. angulosa (EC50 = 3.8 μg/ml), against trypomastigote forms. In intracellular amastigote forms, the extract of T. ignis showed IC50 of 7.2 μg/ml and SI of 24.65. On this basis, our results indicate that these extracts can be promising chemotherapeutic agents against T. cruzi.Sociedade Brasileira de Farmacognosia2015-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600651Revista Brasileira de Farmacognosia v.25 n.6 2015reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.08.011info:eu-repo/semantics/openAccessPaula,Jéssica Carreira deDesoti,Vânia CristinaSampiron,Eloísa GibinMartins,Solange CardosoUeda-Nakamura,TâniaRibeiro,Suzi MenesesBianco,Everson MiguelSilva,Sueli de OliveiraOliveira,Gibson Gomes deNakamura,Celso Vatarueng2015-12-22T00:00:00Zoai:scielo:S0102-695X2015000600651Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2015-12-22T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges |
title |
Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges |
spellingShingle |
Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges Paula,Jéssica Carreira de Chagas’ disease Trypanosoma cruzi Natural products Marine sponges |
title_short |
Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges |
title_full |
Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges |
title_fullStr |
Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges |
title_full_unstemmed |
Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges |
title_sort |
Trypanocidal activity of organic extracts from the Brazilian and Spanish marine sponges |
author |
Paula,Jéssica Carreira de |
author_facet |
Paula,Jéssica Carreira de Desoti,Vânia Cristina Sampiron,Eloísa Gibin Martins,Solange Cardoso Ueda-Nakamura,Tânia Ribeiro,Suzi Meneses Bianco,Everson Miguel Silva,Sueli de Oliveira Oliveira,Gibson Gomes de Nakamura,Celso Vataru |
author_role |
author |
author2 |
Desoti,Vânia Cristina Sampiron,Eloísa Gibin Martins,Solange Cardoso Ueda-Nakamura,Tânia Ribeiro,Suzi Meneses Bianco,Everson Miguel Silva,Sueli de Oliveira Oliveira,Gibson Gomes de Nakamura,Celso Vataru |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Paula,Jéssica Carreira de Desoti,Vânia Cristina Sampiron,Eloísa Gibin Martins,Solange Cardoso Ueda-Nakamura,Tânia Ribeiro,Suzi Meneses Bianco,Everson Miguel Silva,Sueli de Oliveira Oliveira,Gibson Gomes de Nakamura,Celso Vataru |
dc.subject.por.fl_str_mv |
Chagas’ disease Trypanosoma cruzi Natural products Marine sponges |
topic |
Chagas’ disease Trypanosoma cruzi Natural products Marine sponges |
description |
Abstract Chagas' disease is a parasitic infection caused by protozoan Trypanosoma cruzi that affect millions of people worldwide. The available drugs for treatment of this infection cause serious side effects and have variable efficacy, especially in the chronic phase of the disease. In this context, natural compounds have shown great potential for the discovery of new chemotherapies for the treatment of this infection and various other diseases. In present study, we evaluated the in vitro antiprotozoal activity of five species of Brazilian and Spanish marine sponges (Condrosia reniformes, Tethya rubra, Tethya ignis, Mycale angulosa and Dysidea avara) against T. cruzi. By GC–MS data, we observed that in these extracts were present the major classes of the following compounds: hydrocarbons, terpenes, steroids and alcohols. The extracts showed activity against the three forms of this parasite and did not induce toxicity in mammalian cells. Better activities were observed with the extracts of marine sponges, C. reniformes (EC50 = 0.6 μg/ml), D. avara (EC50 = 1.1 μg/ml) and M. angulosa (EC50 = 3.8 μg/ml), against trypomastigote forms. In intracellular amastigote forms, the extract of T. ignis showed IC50 of 7.2 μg/ml and SI of 24.65. On this basis, our results indicate that these extracts can be promising chemotherapeutic agents against T. cruzi. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600651 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2015000600651 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2015.08.011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.25 n.6 2015 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122469651578880 |