Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds

Detalhes bibliográficos
Autor(a) principal: Ibrahim,Sabrin
Data de Publicação: 2016
Outros Autores: Al Haidari,Rwaida, Mohamed,Gamal, Elkhayat,Ehab, Moustafa,Mohamed
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600701
Resumo: ABSTRACT Phytochemical investigation of the MeOH extract of Cucumis melo L. var. reticulates, Cucurbitaceae, seeds led to the isolation of a new triterpenoid: cucumol A (27-hydroxy taraxerol-3β-ol), along with three known compounds: α-spinasterol and D:B-friedoolean-5-ene-3-β-ol. Their structures were established by extensive 1D (1H, 13C, and DEPT) and 2D (1H–1H COSY, HMQC, and HMBC) NMR, as well as IR and HRESIMS spectral analyses. Compound 3 displayed cytotoxic activity against L5178Y and Hela cancer cell lines with ED50 of 1.30 and 5.40 µg/ml, respectively compared to paclitaxel (0.07 and 0.92 µg/ml, respectively).
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spelling Cucumol A: a cytotoxic triterpenoid from Cucumis melo seedsCucumis meloCucurbitaceaeTriterpenoidCucumol ACytotoxic activityABSTRACT Phytochemical investigation of the MeOH extract of Cucumis melo L. var. reticulates, Cucurbitaceae, seeds led to the isolation of a new triterpenoid: cucumol A (27-hydroxy taraxerol-3β-ol), along with three known compounds: α-spinasterol and D:B-friedoolean-5-ene-3-β-ol. Their structures were established by extensive 1D (1H, 13C, and DEPT) and 2D (1H–1H COSY, HMQC, and HMBC) NMR, as well as IR and HRESIMS spectral analyses. Compound 3 displayed cytotoxic activity against L5178Y and Hela cancer cell lines with ED50 of 1.30 and 5.40 µg/ml, respectively compared to paclitaxel (0.07 and 0.92 µg/ml, respectively).Sociedade Brasileira de Farmacognosia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600701Revista Brasileira de Farmacognosia v.26 n.6 2016reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2016.03.012info:eu-repo/semantics/openAccessIbrahim,SabrinAl Haidari,RwaidaMohamed,GamalElkhayat,EhabMoustafa,Mohamedeng2016-12-05T00:00:00Zoai:scielo:S0102-695X2016000600701Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2016-12-05T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
title Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
spellingShingle Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
Ibrahim,Sabrin
Cucumis melo
Cucurbitaceae
Triterpenoid
Cucumol A
Cytotoxic activity
title_short Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
title_full Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
title_fullStr Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
title_full_unstemmed Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
title_sort Cucumol A: a cytotoxic triterpenoid from Cucumis melo seeds
author Ibrahim,Sabrin
author_facet Ibrahim,Sabrin
Al Haidari,Rwaida
Mohamed,Gamal
Elkhayat,Ehab
Moustafa,Mohamed
author_role author
author2 Al Haidari,Rwaida
Mohamed,Gamal
Elkhayat,Ehab
Moustafa,Mohamed
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ibrahim,Sabrin
Al Haidari,Rwaida
Mohamed,Gamal
Elkhayat,Ehab
Moustafa,Mohamed
dc.subject.por.fl_str_mv Cucumis melo
Cucurbitaceae
Triterpenoid
Cucumol A
Cytotoxic activity
topic Cucumis melo
Cucurbitaceae
Triterpenoid
Cucumol A
Cytotoxic activity
description ABSTRACT Phytochemical investigation of the MeOH extract of Cucumis melo L. var. reticulates, Cucurbitaceae, seeds led to the isolation of a new triterpenoid: cucumol A (27-hydroxy taraxerol-3β-ol), along with three known compounds: α-spinasterol and D:B-friedoolean-5-ene-3-β-ol. Their structures were established by extensive 1D (1H, 13C, and DEPT) and 2D (1H–1H COSY, HMQC, and HMBC) NMR, as well as IR and HRESIMS spectral analyses. Compound 3 displayed cytotoxic activity against L5178Y and Hela cancer cell lines with ED50 of 1.30 and 5.40 µg/ml, respectively compared to paclitaxel (0.07 and 0.92 µg/ml, respectively).
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600701
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600701
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2016.03.012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.26 n.6 2016
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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