Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida

• Autor(a) principal: Martins,Marina V.
• Data de Publicação: 2012
• Outros Autores: Estevam,Charles dos S., Santos,André L. L. M., Dias,Antonio S., Cupertino-da-Silva,Yolanda K., Araújo-Júnior,João X., Miranda,Ana Luisa P., Barreiro,Eliezer J., Pizza,Cosimo, Piacente,Sonia, Montoro,Paola, Quintans-Júnior,Lucindo J., Araujo,Brancilene S., Alexandre-Moreira,Magna S., Sant'Ana,Antônio E.G.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000300018
• topic: anti-inflammatory activity; antinociceptive activity; Maytenus rigida; Celastraceae; (-)-4'-methylepigallocatechin

The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4'-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed significantly increased reaction times (60-89%). Oral administration of 1 significantly inhibited first and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). Ethanol extract and its fraction showed effects on inflammatory pain, while neurogenic and inflammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-inflammatory potential.