Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro

Detalhes bibliográficos
Autor(a) principal: Ma,Qinge
Data de Publicação: 2016
Outros Autores: Guo,Yongming, Wei,Rongrui, Sang,Zhipei, Liu,Wenmin, Gao,Li, Liu,Taotao
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600710
Resumo: ABSTRACT Two new flavonoids (1 and 2), named 4',7-dihydroxy-5-hydroxymethyl-8-prenylflavonoid and 4',7-dihydroxy-5-hydroxymethyl-6,8-diprenylflavonoid, together with seven known flavonoids (3–9) were isolated from the aerial parts of Capsella bursa-pastoris (L.) Medik., Brassicaceae, for the first time. The chemical structures of the purified compounds (1–9) were identified by their spectroscopic data and references. Moreover, compounds (1–9) were evaluated for their hepatoprotective activities against D-galactosamine induced toxicity in WB-F344 cells by using a MTT colorimetric method. As a result, compounds 2, 3, 6, and 9 (10 µM) exhibited moderate hepatoprotective activities.
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spelling Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro5-Hydroxymethyl flavonoidNMRHR-ESI-MSSpectral dataIn vitroHepatoprotective activityABSTRACT Two new flavonoids (1 and 2), named 4',7-dihydroxy-5-hydroxymethyl-8-prenylflavonoid and 4',7-dihydroxy-5-hydroxymethyl-6,8-diprenylflavonoid, together with seven known flavonoids (3–9) were isolated from the aerial parts of Capsella bursa-pastoris (L.) Medik., Brassicaceae, for the first time. The chemical structures of the purified compounds (1–9) were identified by their spectroscopic data and references. Moreover, compounds (1–9) were evaluated for their hepatoprotective activities against D-galactosamine induced toxicity in WB-F344 cells by using a MTT colorimetric method. As a result, compounds 2, 3, 6, and 9 (10 µM) exhibited moderate hepatoprotective activities.Sociedade Brasileira de Farmacognosia2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600710Revista Brasileira de Farmacognosia v.26 n.6 2016reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2016.06.006info:eu-repo/semantics/openAccessMa,QingeGuo,YongmingWei,RongruiSang,ZhipeiLiu,WenminGao,LiLiu,Taotaoeng2016-12-05T00:00:00Zoai:scielo:S0102-695X2016000600710Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2016-12-05T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro
title Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro
spellingShingle Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro
Ma,Qinge
5-Hydroxymethyl flavonoid
NMR
HR-ESI-MS
Spectral data
In vitro
Hepatoprotective activity
title_short Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro
title_full Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro
title_fullStr Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro
title_full_unstemmed Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro
title_sort Flavonoids from Capsella bursa-pastoris and their hepatoprotective activities in vitro
author Ma,Qinge
author_facet Ma,Qinge
Guo,Yongming
Wei,Rongrui
Sang,Zhipei
Liu,Wenmin
Gao,Li
Liu,Taotao
author_role author
author2 Guo,Yongming
Wei,Rongrui
Sang,Zhipei
Liu,Wenmin
Gao,Li
Liu,Taotao
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ma,Qinge
Guo,Yongming
Wei,Rongrui
Sang,Zhipei
Liu,Wenmin
Gao,Li
Liu,Taotao
dc.subject.por.fl_str_mv 5-Hydroxymethyl flavonoid
NMR
HR-ESI-MS
Spectral data
In vitro
Hepatoprotective activity
topic 5-Hydroxymethyl flavonoid
NMR
HR-ESI-MS
Spectral data
In vitro
Hepatoprotective activity
description ABSTRACT Two new flavonoids (1 and 2), named 4',7-dihydroxy-5-hydroxymethyl-8-prenylflavonoid and 4',7-dihydroxy-5-hydroxymethyl-6,8-diprenylflavonoid, together with seven known flavonoids (3–9) were isolated from the aerial parts of Capsella bursa-pastoris (L.) Medik., Brassicaceae, for the first time. The chemical structures of the purified compounds (1–9) were identified by their spectroscopic data and references. Moreover, compounds (1–9) were evaluated for their hepatoprotective activities against D-galactosamine induced toxicity in WB-F344 cells by using a MTT colorimetric method. As a result, compounds 2, 3, 6, and 9 (10 µM) exhibited moderate hepatoprotective activities.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600710
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000600710
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2016.06.006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.26 n.6 2016
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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