Chemical constituents of Lecythis pisonis and cytotoxic activity

• Autor(a) principal: Oliveira,Jocélia P. C.
• Data de Publicação: 2012
• Outros Autores: Ferreira,Éverton L. F., Chaves,Mariana H., Militão,Gardenia C. G., V. Júnior,Gerardo M., Costa,Arenice de M., Pessoa,Cláudia do Ó, Moraes,Manoel O. de, Costa-Lotufo,Letícia V.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500028
• topic: Lecythis pisonis; Lecythidaceae; triterpenes; cytotoxicity

The phytochemical investigation of the ethanol extract from leaves of Lecythis pisonis Cambess., Lecythidaceae, resulted in the isolation of seven triterpenes: α- and β-amyrin, uvaol and erythrodiol, ursolic and oleanolic acids and 3β-friedelinol, as well as a mixture of sitosterol and stigmasterol steroids and a diterpene (E)-phytol. The structures of these compounds were identified by¹H and 13C NMR spectral analysis and compared with literature data. The mixture of triterpenes ursolic and oleanolic acids isolated from the active ethereal fraction showed moderate cytotoxic activity. This paper describes for the first time the phytochemical and cytotoxic study of Lecythis pisonis' leaves.