Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines

Detalhes bibliográficos
Autor(a) principal: Savietto,Jóice P.
Data de Publicação: 2013
Outros Autores: Furlan,Cláudia M., Motta,Lucimar B., Salatino,Maria Luiza F., Carvalho,João E., Ruiz,Ana Lucia T. G., Salatino,Antonio, Santos,Déborah Yara A. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000400013
Resumo: Several species of Croton have been described with biological activities, mainly due to diterpenes, alkaloids and/or other secondary metabolites. These activities account for the traditional use of Croton species to treat certain diseases in South America, Asia and Western Africa. The crude methanol extracts obtained from leaves and steam bark of Croton dichrous Müll. Arg., C. erythroxyloides Baill., C. myrianthus Müll. Arg. and C. splendidus Mart. ex Colla were tested for antiproliferative activity against ten human cancer cell lines. Chemical analyses of all extracts were carried out by GC/MS and HPLC/MS/MS. The leaf extract obtained from C. erythroxyloides showed potent activity against PC-3 (prostate) and OVCAR-3 (ovary) cell lines. Lupeol is suggested to be involved in such activity. Tiliroside, an acyl-glycosilated flavonoid ubiquitous in all tested extracts, seems to play an important role in the observed moderate activity of most extracts against the leukemia K562 cell lineage.
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spelling Antiproliferative activity of methanol extracts of four species of Croton on different human cell linesantiproliferative activityCroton. Euphorbiaceaehuman cell lineslupeolmethanol extractSeveral species of Croton have been described with biological activities, mainly due to diterpenes, alkaloids and/or other secondary metabolites. These activities account for the traditional use of Croton species to treat certain diseases in South America, Asia and Western Africa. The crude methanol extracts obtained from leaves and steam bark of Croton dichrous Müll. Arg., C. erythroxyloides Baill., C. myrianthus Müll. Arg. and C. splendidus Mart. ex Colla were tested for antiproliferative activity against ten human cancer cell lines. Chemical analyses of all extracts were carried out by GC/MS and HPLC/MS/MS. The leaf extract obtained from C. erythroxyloides showed potent activity against PC-3 (prostate) and OVCAR-3 (ovary) cell lines. Lupeol is suggested to be involved in such activity. Tiliroside, an acyl-glycosilated flavonoid ubiquitous in all tested extracts, seems to play an important role in the observed moderate activity of most extracts against the leukemia K562 cell lineage.Sociedade Brasileira de Farmacognosia2013-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000400013Revista Brasileira de Farmacognosia v.23 n.4 2013reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2013005000058info:eu-repo/semantics/openAccessSavietto,Jóice P.Furlan,Cláudia M.Motta,Lucimar B.Salatino,Maria Luiza F.Carvalho,João E.Ruiz,Ana Lucia T. G.Salatino,AntonioSantos,Déborah Yara A. C.eng2013-09-23T00:00:00Zoai:scielo:S0102-695X2013000400013Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2013-09-23T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
title Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
spellingShingle Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
Savietto,Jóice P.
antiproliferative activity
Croton. Euphorbiaceae
human cell lines
lupeol
methanol extract
title_short Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
title_full Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
title_fullStr Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
title_full_unstemmed Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
title_sort Antiproliferative activity of methanol extracts of four species of Croton on different human cell lines
author Savietto,Jóice P.
author_facet Savietto,Jóice P.
Furlan,Cláudia M.
Motta,Lucimar B.
Salatino,Maria Luiza F.
Carvalho,João E.
Ruiz,Ana Lucia T. G.
Salatino,Antonio
Santos,Déborah Yara A. C.
author_role author
author2 Furlan,Cláudia M.
Motta,Lucimar B.
Salatino,Maria Luiza F.
Carvalho,João E.
Ruiz,Ana Lucia T. G.
Salatino,Antonio
Santos,Déborah Yara A. C.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Savietto,Jóice P.
Furlan,Cláudia M.
Motta,Lucimar B.
Salatino,Maria Luiza F.
Carvalho,João E.
Ruiz,Ana Lucia T. G.
Salatino,Antonio
Santos,Déborah Yara A. C.
dc.subject.por.fl_str_mv antiproliferative activity
Croton. Euphorbiaceae
human cell lines
lupeol
methanol extract
topic antiproliferative activity
Croton. Euphorbiaceae
human cell lines
lupeol
methanol extract
description Several species of Croton have been described with biological activities, mainly due to diterpenes, alkaloids and/or other secondary metabolites. These activities account for the traditional use of Croton species to treat certain diseases in South America, Asia and Western Africa. The crude methanol extracts obtained from leaves and steam bark of Croton dichrous Müll. Arg., C. erythroxyloides Baill., C. myrianthus Müll. Arg. and C. splendidus Mart. ex Colla were tested for antiproliferative activity against ten human cancer cell lines. Chemical analyses of all extracts were carried out by GC/MS and HPLC/MS/MS. The leaf extract obtained from C. erythroxyloides showed potent activity against PC-3 (prostate) and OVCAR-3 (ovary) cell lines. Lupeol is suggested to be involved in such activity. Tiliroside, an acyl-glycosilated flavonoid ubiquitous in all tested extracts, seems to play an important role in the observed moderate activity of most extracts against the leukemia K562 cell lineage.
publishDate 2013
dc.date.none.fl_str_mv 2013-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000400013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000400013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2013005000058
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.23 n.4 2013
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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