Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats

Detalhes bibliográficos
Autor(a) principal: Demirel,Murside Ayse
Data de Publicação: 2016
Outros Autores: Ilhan,Mert, Suntar,Ipek, Keles,Hikmet, Akkol,Esra Kupeli
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000100083
Resumo: Abstract The aim of the present study was to assess the activity of the hazelnut oil in the treatment of polycystic ovary syndrome in rats. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, serum lipid parameters, leptin and glucose levels were evaluated. Moreover, antioxidant activity was tested using superoxide dismutase, malondialdehyde, catalase, glutathione peroxidase levels. The phytosterol content of the oil was determined by HPLC. The plasma high density lipoprotein-cholesterol level was found to be significantly high and leptin and glucose concentrations were found to be significantly low in the treatment group. According to the phytochemical analysis, the main components of the oil were detected as α-tocopherol, γ-tocopherol, squalene, β-sitosterol, campesterol and stigmasterol. Corylus avellana oil was found to be effective in the treatment of polycystic ovary syndrome via regulating gonadotropins, steroids and serum lipid parameters and possesses antioxidant activity.
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spelling Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in ratsBetulaceaeCorylus avellanaPhytosterolLetrozolePolycystic ovary syndromeAntioxidantAbstract The aim of the present study was to assess the activity of the hazelnut oil in the treatment of polycystic ovary syndrome in rats. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, serum lipid parameters, leptin and glucose levels were evaluated. Moreover, antioxidant activity was tested using superoxide dismutase, malondialdehyde, catalase, glutathione peroxidase levels. The phytosterol content of the oil was determined by HPLC. The plasma high density lipoprotein-cholesterol level was found to be significantly high and leptin and glucose concentrations were found to be significantly low in the treatment group. According to the phytochemical analysis, the main components of the oil were detected as α-tocopherol, γ-tocopherol, squalene, β-sitosterol, campesterol and stigmasterol. Corylus avellana oil was found to be effective in the treatment of polycystic ovary syndrome via regulating gonadotropins, steroids and serum lipid parameters and possesses antioxidant activity.Sociedade Brasileira de Farmacognosia2016-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000100083Revista Brasileira de Farmacognosia v.26 n.1 2016reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2015.09.009info:eu-repo/semantics/openAccessDemirel,Murside AyseIlhan,MertSuntar,IpekKeles,HikmetAkkol,Esra Kupelieng2016-02-03T00:00:00Zoai:scielo:S0102-695X2016000100083Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2016-02-03T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats
title Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats
spellingShingle Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats
Demirel,Murside Ayse
Betulaceae
Corylus avellana
Phytosterol
Letrozole
Polycystic ovary syndrome
Antioxidant
title_short Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats
title_full Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats
title_fullStr Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats
title_full_unstemmed Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats
title_sort Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats
author Demirel,Murside Ayse
author_facet Demirel,Murside Ayse
Ilhan,Mert
Suntar,Ipek
Keles,Hikmet
Akkol,Esra Kupeli
author_role author
author2 Ilhan,Mert
Suntar,Ipek
Keles,Hikmet
Akkol,Esra Kupeli
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Demirel,Murside Ayse
Ilhan,Mert
Suntar,Ipek
Keles,Hikmet
Akkol,Esra Kupeli
dc.subject.por.fl_str_mv Betulaceae
Corylus avellana
Phytosterol
Letrozole
Polycystic ovary syndrome
Antioxidant
topic Betulaceae
Corylus avellana
Phytosterol
Letrozole
Polycystic ovary syndrome
Antioxidant
description Abstract The aim of the present study was to assess the activity of the hazelnut oil in the treatment of polycystic ovary syndrome in rats. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, serum lipid parameters, leptin and glucose levels were evaluated. Moreover, antioxidant activity was tested using superoxide dismutase, malondialdehyde, catalase, glutathione peroxidase levels. The phytosterol content of the oil was determined by HPLC. The plasma high density lipoprotein-cholesterol level was found to be significantly high and leptin and glucose concentrations were found to be significantly low in the treatment group. According to the phytochemical analysis, the main components of the oil were detected as α-tocopherol, γ-tocopherol, squalene, β-sitosterol, campesterol and stigmasterol. Corylus avellana oil was found to be effective in the treatment of polycystic ovary syndrome via regulating gonadotropins, steroids and serum lipid parameters and possesses antioxidant activity.
publishDate 2016
dc.date.none.fl_str_mv 2016-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000100083
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000100083
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjp.2015.09.009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.26 n.1 2016
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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