Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina

Detalhes bibliográficos
Autor(a) principal: Mesa,Milagros Garcia
Data de Publicação: 2011
Outros Autores: Piccinelli,Anna Lisa, Valiente,María Antonia Alfonso, Pinto,Aldo, Fazio,Alessia, Rastrelli,Luca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500016
Resumo: Wendtia calycina (Griseb.) Griseb., Vivianiaceae, is a Paraguayan herbaceous plant commonly known as burrito. Our previous study indicated that burrito leaves are a very good source of phenylpropanoid glycosides, principally verbascoside. From W. calycina leaves, a standardized, water-soluble extract rich in phenylpropanoid glycosides (WSE) has been developed on an industrial scale to be used as a food supplement, cosmetic, phytomedicine, and ingredient of different formulations. In this study, we investigated the effect of the WSE on human platelet aggregation in vitro induced by adenosine diphosphate (ADP), epinephrine (EPN), collagen (COL) or arachidonic acid (AA). WSE, concentration-dependently, inhibited ADP and EP-induced human platelet aggregation (IC50 were 0.82±0.15 mg/mL and 0.41±0.02 mg/mL, respectively). It did not inhibit collagen-induced platelet aggregation, thus suggesting a selectivity for the ADP-induced platelet activation pathways.
id SBFGNOSIA-1_6b13c6a2f8ea5082f0d4b745407868b3
oai_identifier_str oai:scielo:S0102-695X2011000500016
network_acronym_str SBFGNOSIA-1
network_name_str Revista Brasileira de Farmacognosia (Online)
repository_id_str
spelling Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycinaWendtia calycina leavesPhenylpropanoid glycosidesHuman platelet aggregationWendtia calycina (Griseb.) Griseb., Vivianiaceae, is a Paraguayan herbaceous plant commonly known as burrito. Our previous study indicated that burrito leaves are a very good source of phenylpropanoid glycosides, principally verbascoside. From W. calycina leaves, a standardized, water-soluble extract rich in phenylpropanoid glycosides (WSE) has been developed on an industrial scale to be used as a food supplement, cosmetic, phytomedicine, and ingredient of different formulations. In this study, we investigated the effect of the WSE on human platelet aggregation in vitro induced by adenosine diphosphate (ADP), epinephrine (EPN), collagen (COL) or arachidonic acid (AA). WSE, concentration-dependently, inhibited ADP and EP-induced human platelet aggregation (IC50 were 0.82±0.15 mg/mL and 0.41±0.02 mg/mL, respectively). It did not inhibit collagen-induced platelet aggregation, thus suggesting a selectivity for the ADP-induced platelet activation pathways.Sociedade Brasileira de Farmacognosia2011-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500016Revista Brasileira de Farmacognosia v.21 n.5 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2011005000109info:eu-repo/semantics/openAccessMesa,Milagros GarciaPiccinelli,Anna LisaValiente,María Antonia AlfonsoPinto,AldoFazio,AlessiaRastrelli,Lucaeng2011-09-23T00:00:00Zoai:scielo:S0102-695X2011000500016Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2011-09-23T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina
title Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina
spellingShingle Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina
Mesa,Milagros Garcia
Wendtia calycina leaves
Phenylpropanoid glycosides
Human platelet aggregation
title_short Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina
title_full Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina
title_fullStr Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina
title_full_unstemmed Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina
title_sort Inhibition of human platelet aggregation in vitro by standardized extract of Wendtia calycina
author Mesa,Milagros Garcia
author_facet Mesa,Milagros Garcia
Piccinelli,Anna Lisa
Valiente,María Antonia Alfonso
Pinto,Aldo
Fazio,Alessia
Rastrelli,Luca
author_role author
author2 Piccinelli,Anna Lisa
Valiente,María Antonia Alfonso
Pinto,Aldo
Fazio,Alessia
Rastrelli,Luca
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Mesa,Milagros Garcia
Piccinelli,Anna Lisa
Valiente,María Antonia Alfonso
Pinto,Aldo
Fazio,Alessia
Rastrelli,Luca
dc.subject.por.fl_str_mv Wendtia calycina leaves
Phenylpropanoid glycosides
Human platelet aggregation
topic Wendtia calycina leaves
Phenylpropanoid glycosides
Human platelet aggregation
description Wendtia calycina (Griseb.) Griseb., Vivianiaceae, is a Paraguayan herbaceous plant commonly known as burrito. Our previous study indicated that burrito leaves are a very good source of phenylpropanoid glycosides, principally verbascoside. From W. calycina leaves, a standardized, water-soluble extract rich in phenylpropanoid glycosides (WSE) has been developed on an industrial scale to be used as a food supplement, cosmetic, phytomedicine, and ingredient of different formulations. In this study, we investigated the effect of the WSE on human platelet aggregation in vitro induced by adenosine diphosphate (ADP), epinephrine (EPN), collagen (COL) or arachidonic acid (AA). WSE, concentration-dependently, inhibited ADP and EP-induced human platelet aggregation (IC50 were 0.82±0.15 mg/mL and 0.41±0.02 mg/mL, respectively). It did not inhibit collagen-induced platelet aggregation, thus suggesting a selectivity for the ADP-induced platelet activation pathways.
publishDate 2011
dc.date.none.fl_str_mv 2011-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000500016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2011005000109
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.21 n.5 2011
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
_version_ 1752122466081177600

Registros relacionados