Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300312 |
Resumo: | Abstract The leaves of Garcinia gracilis Pierre, Clusiaceae, have been used as flavouring materials in food, with no previous reports of their biological activities and chemical constituents. In this study, the methanolic extract of G. gracilis afforded three compounds namely apigenin-8-C-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (1), 5-hydroxymethyl-2-furaldehyde, and vanillic acid. All of the isolates were initially evaluated for superoxide anion radical scavenging activity and α-glucosidase inhibitory effects. Compound 1, which was the major component, showed the most potent activities among these three isolates. Further biological evaluations revealed that compound 1 could prevent the pBR322 plasmid DNA damage induced by the photochemical reaction of riboflavin and protect P19-derived neurons from the oxidative stress condition induced by serum deprivation. It was concluded that the potent biological activities of G. gracilis could be attributed to the synergistic effect of compound 1 with other constituents found in the plant. |
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Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilisAntioxidantDNA protectiveFlavonoid glycosideGarcinia gracilisα-GlucosidaseNeuroprotectiveAbstract The leaves of Garcinia gracilis Pierre, Clusiaceae, have been used as flavouring materials in food, with no previous reports of their biological activities and chemical constituents. In this study, the methanolic extract of G. gracilis afforded three compounds namely apigenin-8-C-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (1), 5-hydroxymethyl-2-furaldehyde, and vanillic acid. All of the isolates were initially evaluated for superoxide anion radical scavenging activity and α-glucosidase inhibitory effects. Compound 1, which was the major component, showed the most potent activities among these three isolates. Further biological evaluations revealed that compound 1 could prevent the pBR322 plasmid DNA damage induced by the photochemical reaction of riboflavin and protect P19-derived neurons from the oxidative stress condition induced by serum deprivation. It was concluded that the potent biological activities of G. gracilis could be attributed to the synergistic effect of compound 1 with other constituents found in the plant.Sociedade Brasileira de Farmacognosia2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300312Revista Brasileira de Farmacognosia v.26 n.3 2016reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2016.01.007info:eu-repo/semantics/openAccessSupasuteekul,ChonlakanNonthitipong,WanroongTadtong,SarinLikhitwitayawuid,KittisakTengamnuay,ParkpoomSritularak,Boonchooeng2016-06-14T00:00:00Zoai:scielo:S0102-695X2016000300312Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2016-06-14T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis |
title |
Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis |
spellingShingle |
Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis Supasuteekul,Chonlakan Antioxidant DNA protective Flavonoid glycoside Garcinia gracilis α-Glucosidase Neuroprotective |
title_short |
Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis |
title_full |
Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis |
title_fullStr |
Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis |
title_full_unstemmed |
Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis |
title_sort |
Antioxidant, DNA damage protective, neuroprotective, and α-glucosidase inhibitory activities of a flavonoid glycoside from leaves of Garcinia gracilis |
author |
Supasuteekul,Chonlakan |
author_facet |
Supasuteekul,Chonlakan Nonthitipong,Wanroong Tadtong,Sarin Likhitwitayawuid,Kittisak Tengamnuay,Parkpoom Sritularak,Boonchoo |
author_role |
author |
author2 |
Nonthitipong,Wanroong Tadtong,Sarin Likhitwitayawuid,Kittisak Tengamnuay,Parkpoom Sritularak,Boonchoo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Supasuteekul,Chonlakan Nonthitipong,Wanroong Tadtong,Sarin Likhitwitayawuid,Kittisak Tengamnuay,Parkpoom Sritularak,Boonchoo |
dc.subject.por.fl_str_mv |
Antioxidant DNA protective Flavonoid glycoside Garcinia gracilis α-Glucosidase Neuroprotective |
topic |
Antioxidant DNA protective Flavonoid glycoside Garcinia gracilis α-Glucosidase Neuroprotective |
description |
Abstract The leaves of Garcinia gracilis Pierre, Clusiaceae, have been used as flavouring materials in food, with no previous reports of their biological activities and chemical constituents. In this study, the methanolic extract of G. gracilis afforded three compounds namely apigenin-8-C-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside (1), 5-hydroxymethyl-2-furaldehyde, and vanillic acid. All of the isolates were initially evaluated for superoxide anion radical scavenging activity and α-glucosidase inhibitory effects. Compound 1, which was the major component, showed the most potent activities among these three isolates. Further biological evaluations revealed that compound 1 could prevent the pBR322 plasmid DNA damage induced by the photochemical reaction of riboflavin and protect P19-derived neurons from the oxidative stress condition induced by serum deprivation. It was concluded that the potent biological activities of G. gracilis could be attributed to the synergistic effect of compound 1 with other constituents found in the plant. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300312 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2016000300312 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2016.01.007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.26 n.3 2016 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122469750145024 |