Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatment
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500011 |
Resumo: | Some compounds present in therapeutic plants may be responsible for the occurrence of adverse side effects. Coumarin and flavonoids are substances found in many plant species that showed antifertility activity in female rats and dogs, respectively. Mikania glomerata Spreng., Asteraceae, known as guaco in Brazil, is a plant largely used in folk medicine and its leaves are reported to have coumarin and flavonoids. This work analyzes the effect of chronic administration of M. glomerata on the reproductive system of male rats. Thirty-day-old Wistar rats were treated with M. glomerata hydroalcoholic extract at a dose of 3.3 g/kg of body weight for ninety days. Body and organ weights, gamete concentration on the epididymis cauda, serum testosterone level and food consumption were evaluated. No significant alteration was observed in any of the variables analyzed, suggesting the absence of toxic action or antifertility activity of the M. glomerata hydroalcoholic extract. |
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Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatmentMikania glomeratareproductive organssperm productiontestosterone levelWistar ratSome compounds present in therapeutic plants may be responsible for the occurrence of adverse side effects. Coumarin and flavonoids are substances found in many plant species that showed antifertility activity in female rats and dogs, respectively. Mikania glomerata Spreng., Asteraceae, known as guaco in Brazil, is a plant largely used in folk medicine and its leaves are reported to have coumarin and flavonoids. This work analyzes the effect of chronic administration of M. glomerata on the reproductive system of male rats. Thirty-day-old Wistar rats were treated with M. glomerata hydroalcoholic extract at a dose of 3.3 g/kg of body weight for ninety days. Body and organ weights, gamete concentration on the epididymis cauda, serum testosterone level and food consumption were evaluated. No significant alteration was observed in any of the variables analyzed, suggesting the absence of toxic action or antifertility activity of the M. glomerata hydroalcoholic extract.Sociedade Brasileira de Farmacognosia2010-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500011Revista Brasileira de Farmacognosia v.20 n.5 2010reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2010005000007info:eu-repo/semantics/openAccessSá,Rita de Cássia da Silveira eLeite,Magda N.Almeida,Reinaldo N. deeng2010-11-26T00:00:00Zoai:scielo:S0102-695X2010000500011Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2010-11-26T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatment |
title |
Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatment |
spellingShingle |
Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatment Sá,Rita de Cássia da Silveira e Mikania glomerata reproductive organs sperm production testosterone level Wistar rat |
title_short |
Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatment |
title_full |
Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatment |
title_fullStr |
Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatment |
title_full_unstemmed |
Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatment |
title_sort |
Toxicological screening of Mikania glomerata Spreng., Asteraceae, extract in male Wistar rats reproductive system, sperm production and testosterone level after chronic treatment |
author |
Sá,Rita de Cássia da Silveira e |
author_facet |
Sá,Rita de Cássia da Silveira e Leite,Magda N. Almeida,Reinaldo N. de |
author_role |
author |
author2 |
Leite,Magda N. Almeida,Reinaldo N. de |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Sá,Rita de Cássia da Silveira e Leite,Magda N. Almeida,Reinaldo N. de |
dc.subject.por.fl_str_mv |
Mikania glomerata reproductive organs sperm production testosterone level Wistar rat |
topic |
Mikania glomerata reproductive organs sperm production testosterone level Wistar rat |
description |
Some compounds present in therapeutic plants may be responsible for the occurrence of adverse side effects. Coumarin and flavonoids are substances found in many plant species that showed antifertility activity in female rats and dogs, respectively. Mikania glomerata Spreng., Asteraceae, known as guaco in Brazil, is a plant largely used in folk medicine and its leaves are reported to have coumarin and flavonoids. This work analyzes the effect of chronic administration of M. glomerata on the reproductive system of male rats. Thirty-day-old Wistar rats were treated with M. glomerata hydroalcoholic extract at a dose of 3.3 g/kg of body weight for ninety days. Body and organ weights, gamete concentration on the epididymis cauda, serum testosterone level and food consumption were evaluated. No significant alteration was observed in any of the variables analyzed, suggesting the absence of toxic action or antifertility activity of the M. glomerata hydroalcoholic extract. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000500011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-695X2010005000007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.20 n.5 2010 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122464668745728 |