Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models

Detalhes bibliográficos
Autor(a) principal: Guimarães,Heloisa Alves
Data de Publicação: 2010
Outros Autores: Nascimento,Marcus Vinícius M., Tavares,Adriano, Galdino,Pablinny Moreira, Paula,José Realino de, Costa,Elson Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000300007
Resumo: Lafoensia pacari A. St.-Hil., Lythraceae, popularly known as pacari, is a Cerrado's native specimen; the stem bark extract is used in folk for pain and inflammation, also showing sedating activity. This study aimed to evaluate the analgesic and anti inflammatory activities of ethanol extract from pacari leaves (EEPL). These activities were verified in mice. The previous treatment with EEPL 1.0 g/kg showed antinociceptive activity both in the acetic acid-induced writing test and in the formalin-induced model of pain, and in neurogenic and inflammatory phases as well. In the croton oil-induced ear edema, the pre-treatments with EEPL reduced the edema in a dose-dependent manner. Also in the carrageenan-induced peritonitis, the two major doses tested (2.0 and 1.5 g/kg p.o.) were able to reduce the leukocyte migration in a dose-dependent manner. The Central Nervous System tests showed that the extract does not elicit uncoordinated motricity, hypnosis or sedating effects. The results showed that EEPL maintains the analgesic and anti-inflammatory effects of the stem bark of pacari, being the collect of leaves more favorable to the preservation of this Cerrado's native specimen.
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spelling Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation modelsPaininflammationleaf extractLafoensia pacariLythraceaeLafoensia pacari A. St.-Hil., Lythraceae, popularly known as pacari, is a Cerrado's native specimen; the stem bark extract is used in folk for pain and inflammation, also showing sedating activity. This study aimed to evaluate the analgesic and anti inflammatory activities of ethanol extract from pacari leaves (EEPL). These activities were verified in mice. The previous treatment with EEPL 1.0 g/kg showed antinociceptive activity both in the acetic acid-induced writing test and in the formalin-induced model of pain, and in neurogenic and inflammatory phases as well. In the croton oil-induced ear edema, the pre-treatments with EEPL reduced the edema in a dose-dependent manner. Also in the carrageenan-induced peritonitis, the two major doses tested (2.0 and 1.5 g/kg p.o.) were able to reduce the leukocyte migration in a dose-dependent manner. The Central Nervous System tests showed that the extract does not elicit uncoordinated motricity, hypnosis or sedating effects. The results showed that EEPL maintains the analgesic and anti-inflammatory effects of the stem bark of pacari, being the collect of leaves more favorable to the preservation of this Cerrado's native specimen.Sociedade Brasileira de Farmacognosia2010-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000300007Revista Brasileira de Farmacognosia v.20 n.3 2010reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2010000300007info:eu-repo/semantics/openAccessGuimarães,Heloisa AlvesNascimento,Marcus Vinícius M.Tavares,AdrianoGaldino,Pablinny MoreiraPaula,José Realino deCosta,Elson Alveseng2010-08-03T00:00:00Zoai:scielo:S0102-695X2010000300007Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2010-08-03T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models
title Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models
spellingShingle Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models
Guimarães,Heloisa Alves
Pain
inflammation
leaf extract
Lafoensia pacari
Lythraceae
title_short Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models
title_full Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models
title_fullStr Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models
title_full_unstemmed Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models
title_sort Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models
author Guimarães,Heloisa Alves
author_facet Guimarães,Heloisa Alves
Nascimento,Marcus Vinícius M.
Tavares,Adriano
Galdino,Pablinny Moreira
Paula,José Realino de
Costa,Elson Alves
author_role author
author2 Nascimento,Marcus Vinícius M.
Tavares,Adriano
Galdino,Pablinny Moreira
Paula,José Realino de
Costa,Elson Alves
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Guimarães,Heloisa Alves
Nascimento,Marcus Vinícius M.
Tavares,Adriano
Galdino,Pablinny Moreira
Paula,José Realino de
Costa,Elson Alves
dc.subject.por.fl_str_mv Pain
inflammation
leaf extract
Lafoensia pacari
Lythraceae
topic Pain
inflammation
leaf extract
Lafoensia pacari
Lythraceae
description Lafoensia pacari A. St.-Hil., Lythraceae, popularly known as pacari, is a Cerrado's native specimen; the stem bark extract is used in folk for pain and inflammation, also showing sedating activity. This study aimed to evaluate the analgesic and anti inflammatory activities of ethanol extract from pacari leaves (EEPL). These activities were verified in mice. The previous treatment with EEPL 1.0 g/kg showed antinociceptive activity both in the acetic acid-induced writing test and in the formalin-induced model of pain, and in neurogenic and inflammatory phases as well. In the croton oil-induced ear edema, the pre-treatments with EEPL reduced the edema in a dose-dependent manner. Also in the carrageenan-induced peritonitis, the two major doses tested (2.0 and 1.5 g/kg p.o.) were able to reduce the leukocyte migration in a dose-dependent manner. The Central Nervous System tests showed that the extract does not elicit uncoordinated motricity, hypnosis or sedating effects. The results showed that EEPL maintains the analgesic and anti-inflammatory effects of the stem bark of pacari, being the collect of leaves more favorable to the preservation of this Cerrado's native specimen.
publishDate 2010
dc.date.none.fl_str_mv 2010-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000300007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2010000300007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2010000300007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.20 n.3 2010
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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