Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000500582 |
Resumo: | Abstract The species Waltheria viscosissima A.St.–Hil, Malvaceae, which is known as ‘malva-branca', is traditionally used in the Brazilian northeast for the treatment of coughs. This research looks towards reporting the isolation of phytoconstituents of W. viscosissima, as well as the quantification of its phenolics, total flavonoid content, and free radical scavenging potential, along with an evaluation of its larvicidal activity against Aedes aegypti larvae. Chromatographic techniques were used to isolate the compounds and a structural elucidation was performed by 1D and 2D NMR. The quantification of total phenolics and flavonoids and the DPPH˙ radical scavenging activity was determined through spectrophotometric methods. Consequently, the phytochemical investigation led to the identification of fourteen compounds from the aerial parts of the W. viscosissima: steroids, triterpenes, alkaloids, and eight flavonoids previously reported in the literature. The quantification of compounds showed that the aerial parts extract possessed high concentration of flavonoids, while the roots extract were rich in other phenolic compounds. At the DPPH˙ free radical scavenging assay, the roots extract presented EC50 = 77.32 ± 4.37 µg/ml and the aerial parts extracts showed EC50 = 118.10 ± 1.21 µg/ml. W. viscosissima roots extract showed the most potent larvicidal activity against Ae. aegypti (LC50 = 4.78 mg/ml), with the potential of being used in effective and economically viable preparations that can be catered for domestic use towards controlling the vector insect of severe diseases, such as dengue and Zika. |
id |
SBFGNOSIA-1_7996eac8e986346919e3e161c9db33db |
---|---|
oai_identifier_str |
oai:scielo:S0102-695X2019000500582 |
network_acronym_str |
SBFGNOSIA-1 |
network_name_str |
Revista Brasileira de Farmacognosia (Online) |
repository_id_str |
|
spelling |
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegyptiSterculiaceaePhytochemical studyAntioxidant activityLarvicidal assayAedes aegyptiAbstract The species Waltheria viscosissima A.St.–Hil, Malvaceae, which is known as ‘malva-branca', is traditionally used in the Brazilian northeast for the treatment of coughs. This research looks towards reporting the isolation of phytoconstituents of W. viscosissima, as well as the quantification of its phenolics, total flavonoid content, and free radical scavenging potential, along with an evaluation of its larvicidal activity against Aedes aegypti larvae. Chromatographic techniques were used to isolate the compounds and a structural elucidation was performed by 1D and 2D NMR. The quantification of total phenolics and flavonoids and the DPPH˙ radical scavenging activity was determined through spectrophotometric methods. Consequently, the phytochemical investigation led to the identification of fourteen compounds from the aerial parts of the W. viscosissima: steroids, triterpenes, alkaloids, and eight flavonoids previously reported in the literature. The quantification of compounds showed that the aerial parts extract possessed high concentration of flavonoids, while the roots extract were rich in other phenolic compounds. At the DPPH˙ free radical scavenging assay, the roots extract presented EC50 = 77.32 ± 4.37 µg/ml and the aerial parts extracts showed EC50 = 118.10 ± 1.21 µg/ml. W. viscosissima roots extract showed the most potent larvicidal activity against Ae. aegypti (LC50 = 4.78 mg/ml), with the potential of being used in effective and economically viable preparations that can be catered for domestic use towards controlling the vector insect of severe diseases, such as dengue and Zika.Sociedade Brasileira de Farmacognosia2019-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000500582Revista Brasileira de Farmacognosia v.29 n.5 2019reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2019.05.008info:eu-repo/semantics/openAccessFerreira,Maria Denise LeiteFernandes,Diégina A.Nunes,Fabíola C.Teles,Yanna C.F.Rolim,Yngred M.Silva,Camila Macaúbas daAlbuquerque,Janderson B.L. deAgra,Maria de FátimaSouza,Maria de F.V. deeng2019-12-05T00:00:00Zoai:scielo:S0102-695X2019000500582Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2019-12-05T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti |
title |
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti |
spellingShingle |
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti Ferreira,Maria Denise Leite Sterculiaceae Phytochemical study Antioxidant activity Larvicidal assay Aedes aegypti |
title_short |
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti |
title_full |
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti |
title_fullStr |
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti |
title_full_unstemmed |
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti |
title_sort |
Phytochemical study of Waltheria viscosissima and evaluation of its larvicidal activity against Aedes aegypti |
author |
Ferreira,Maria Denise Leite |
author_facet |
Ferreira,Maria Denise Leite Fernandes,Diégina A. Nunes,Fabíola C. Teles,Yanna C.F. Rolim,Yngred M. Silva,Camila Macaúbas da Albuquerque,Janderson B.L. de Agra,Maria de Fátima Souza,Maria de F.V. de |
author_role |
author |
author2 |
Fernandes,Diégina A. Nunes,Fabíola C. Teles,Yanna C.F. Rolim,Yngred M. Silva,Camila Macaúbas da Albuquerque,Janderson B.L. de Agra,Maria de Fátima Souza,Maria de F.V. de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira,Maria Denise Leite Fernandes,Diégina A. Nunes,Fabíola C. Teles,Yanna C.F. Rolim,Yngred M. Silva,Camila Macaúbas da Albuquerque,Janderson B.L. de Agra,Maria de Fátima Souza,Maria de F.V. de |
dc.subject.por.fl_str_mv |
Sterculiaceae Phytochemical study Antioxidant activity Larvicidal assay Aedes aegypti |
topic |
Sterculiaceae Phytochemical study Antioxidant activity Larvicidal assay Aedes aegypti |
description |
Abstract The species Waltheria viscosissima A.St.–Hil, Malvaceae, which is known as ‘malva-branca', is traditionally used in the Brazilian northeast for the treatment of coughs. This research looks towards reporting the isolation of phytoconstituents of W. viscosissima, as well as the quantification of its phenolics, total flavonoid content, and free radical scavenging potential, along with an evaluation of its larvicidal activity against Aedes aegypti larvae. Chromatographic techniques were used to isolate the compounds and a structural elucidation was performed by 1D and 2D NMR. The quantification of total phenolics and flavonoids and the DPPH˙ radical scavenging activity was determined through spectrophotometric methods. Consequently, the phytochemical investigation led to the identification of fourteen compounds from the aerial parts of the W. viscosissima: steroids, triterpenes, alkaloids, and eight flavonoids previously reported in the literature. The quantification of compounds showed that the aerial parts extract possessed high concentration of flavonoids, while the roots extract were rich in other phenolic compounds. At the DPPH˙ free radical scavenging assay, the roots extract presented EC50 = 77.32 ± 4.37 µg/ml and the aerial parts extracts showed EC50 = 118.10 ± 1.21 µg/ml. W. viscosissima roots extract showed the most potent larvicidal activity against Ae. aegypti (LC50 = 4.78 mg/ml), with the potential of being used in effective and economically viable preparations that can be catered for domestic use towards controlling the vector insect of severe diseases, such as dengue and Zika. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000500582 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000500582 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2019.05.008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.29 n.5 2019 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
_version_ |
1752122471300988928 |