Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Farmacognosia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000300389 |
Resumo: | ABSTRACT Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET PredictorTM software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary. |
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Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compoundsBrazilian stingless beePropolisGeopropolisChemical compositionBiological activityABSTRACT Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET PredictorTM software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary.Sociedade Brasileira de Farmacognosia2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000300389Revista Brasileira de Farmacognosia v.29 n.3 2019reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1016/j.bjp.2018.11.007info:eu-repo/semantics/openAccessLavinas,Flavia C.Macedo,Ellis Helena B.C.Sá,Gabriel B.L.Amaral,Ana Claudia F.Silva,Jefferson R.A.Azevedo,Mariana M.B.Vieira,Bárbara A.Domingos,Thaisa Francielle S.Vermelho,Alane B.Carneiro,Carla S.Rodrigues,Igor A.eng2019-08-22T00:00:00Zoai:scielo:S0102-695X2019000300389Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2019-08-22T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false |
dc.title.none.fl_str_mv |
Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds |
title |
Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds |
spellingShingle |
Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds Lavinas,Flavia C. Brazilian stingless bee Propolis Geopropolis Chemical composition Biological activity |
title_short |
Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds |
title_full |
Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds |
title_fullStr |
Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds |
title_full_unstemmed |
Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds |
title_sort |
Brazilian stingless bee propolis and geopropolis: promising sources of biologically active compounds |
author |
Lavinas,Flavia C. |
author_facet |
Lavinas,Flavia C. Macedo,Ellis Helena B.C. Sá,Gabriel B.L. Amaral,Ana Claudia F. Silva,Jefferson R.A. Azevedo,Mariana M.B. Vieira,Bárbara A. Domingos,Thaisa Francielle S. Vermelho,Alane B. Carneiro,Carla S. Rodrigues,Igor A. |
author_role |
author |
author2 |
Macedo,Ellis Helena B.C. Sá,Gabriel B.L. Amaral,Ana Claudia F. Silva,Jefferson R.A. Azevedo,Mariana M.B. Vieira,Bárbara A. Domingos,Thaisa Francielle S. Vermelho,Alane B. Carneiro,Carla S. Rodrigues,Igor A. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Lavinas,Flavia C. Macedo,Ellis Helena B.C. Sá,Gabriel B.L. Amaral,Ana Claudia F. Silva,Jefferson R.A. Azevedo,Mariana M.B. Vieira,Bárbara A. Domingos,Thaisa Francielle S. Vermelho,Alane B. Carneiro,Carla S. Rodrigues,Igor A. |
dc.subject.por.fl_str_mv |
Brazilian stingless bee Propolis Geopropolis Chemical composition Biological activity |
topic |
Brazilian stingless bee Propolis Geopropolis Chemical composition Biological activity |
description |
ABSTRACT Stingless bee products such as honey, pollen, propolis, and geopropolis have been used for centuries in traditional medicine for the treatment of several illnesses. Investigation of the biological activity of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties. About 20% of total Neotropical stingless bees can be found in Brazil. Despite the species diversity, studies on their biological activity are scarce. The present review focuses on the antioxidant and antimicrobial activities of propolis and geopropolis from Brazilian stingless bees. In addition, the toxicity of these natural products was addressed. In order to provide new evidences for the toxic potential of propolis and geopropolis components, an in silico analysis was performed using the ADMET PredictorTM software. We observed that most of studies evaluated only crude ethanol extracts of a limited number of stingless bees species. Propolis and geopropolis displayed antioxidant capacity and antimicrobial activity. Concerning the toxic potential, the extracts of stingless bees propolis and geopropolis were considered safe. Nonetheless, in vitro and in vivo toxicological studies are still necessary. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000300389 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2019000300389 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjp.2018.11.007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Farmacognosia |
dc.source.none.fl_str_mv |
Revista Brasileira de Farmacognosia v.29 n.3 2019 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
instname_str |
Sociedade Brasileira de Farmacognosia (SBFgnosia) |
instacron_str |
SBFGNOSIA |
institution |
SBFGNOSIA |
reponame_str |
Revista Brasileira de Farmacognosia (Online) |
collection |
Revista Brasileira de Farmacognosia (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia) |
repository.mail.fl_str_mv |
rbgnosia@ltf.ufpb.br |
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1752122471166771200 |