In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract

Detalhes bibliográficos
Autor(a) principal: Marques,Thiago Henrique Costa
Data de Publicação: 2012
Outros Autores: Melo,Cássio Herbert Santos de, Freitas,Rivelilson Mendes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500016
Resumo: Acute toxicity, antioxidant activity in vitro and general pharmacological effects of the flower crude ethanolic extract of Bellis perennis L., Asteraceae, a popular medicine used in South America, were investigated in mice. The oral route LD50 value was found 2.31 g/kg. Oral administration at doses 50, 100 and 150 mg/kg of the extract neither caused significant changes in general behavior nor led to toxic symptoms. Anxiolytic-like properties were studied in the open field test and the possible antidepressant-like actions were evaluated in the forced swimming test (FST). There is a significant decrease in the number of crossings at all dosages mentioned above, but no sedative effects at any dosages when compared to controls. In the FST, the extract dosage of 150 mg/kg was effective in reducing immobility, along with a significant increase in swimming time. The ethanolic extract showed strong antioxidant potential in vitro, through the removal capacity against hydroxyl radicals and nitric oxide as well as prevented the formation of reactive substances to thiobarbituric acid (TBARS). Together, these results indicate that the ethanolic extract has effect on central nervous system, which might due to its antioxidant property, as demonstrated in vitro methods used. These results suggest that some of the components in ethanolic extract of B. perennis, such as alkaloids, phenolic compounds and flavonoids may have antioxidant, anxiolytic and antidepressant-like properties. Additional investigations are in progress.
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spelling In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extractantidepressantantioxidantanxietyBellis perennisethanolic extractAcute toxicity, antioxidant activity in vitro and general pharmacological effects of the flower crude ethanolic extract of Bellis perennis L., Asteraceae, a popular medicine used in South America, were investigated in mice. The oral route LD50 value was found 2.31 g/kg. Oral administration at doses 50, 100 and 150 mg/kg of the extract neither caused significant changes in general behavior nor led to toxic symptoms. Anxiolytic-like properties were studied in the open field test and the possible antidepressant-like actions were evaluated in the forced swimming test (FST). There is a significant decrease in the number of crossings at all dosages mentioned above, but no sedative effects at any dosages when compared to controls. In the FST, the extract dosage of 150 mg/kg was effective in reducing immobility, along with a significant increase in swimming time. The ethanolic extract showed strong antioxidant potential in vitro, through the removal capacity against hydroxyl radicals and nitric oxide as well as prevented the formation of reactive substances to thiobarbituric acid (TBARS). Together, these results indicate that the ethanolic extract has effect on central nervous system, which might due to its antioxidant property, as demonstrated in vitro methods used. These results suggest that some of the components in ethanolic extract of B. perennis, such as alkaloids, phenolic compounds and flavonoids may have antioxidant, anxiolytic and antidepressant-like properties. Additional investigations are in progress.Sociedade Brasileira de Farmacognosia2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500016Revista Brasileira de Farmacognosia v.22 n.5 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2012005000082info:eu-repo/semantics/openAccessMarques,Thiago Henrique CostaMelo,Cássio Herbert Santos deFreitas,Rivelilson Mendes deeng2012-09-18T00:00:00Zoai:scielo:S0102-695X2012000500016Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2012-09-18T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract
title In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract
spellingShingle In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract
Marques,Thiago Henrique Costa
antidepressant
antioxidant
anxiety
Bellis perennis
ethanolic extract
title_short In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract
title_full In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract
title_fullStr In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract
title_full_unstemmed In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract
title_sort In vitro evaluation of antioxidant, anxiolytic and antidepressant-like effects of the Bellis perennis extract
author Marques,Thiago Henrique Costa
author_facet Marques,Thiago Henrique Costa
Melo,Cássio Herbert Santos de
Freitas,Rivelilson Mendes de
author_role author
author2 Melo,Cássio Herbert Santos de
Freitas,Rivelilson Mendes de
author2_role author
author
dc.contributor.author.fl_str_mv Marques,Thiago Henrique Costa
Melo,Cássio Herbert Santos de
Freitas,Rivelilson Mendes de
dc.subject.por.fl_str_mv antidepressant
antioxidant
anxiety
Bellis perennis
ethanolic extract
topic antidepressant
antioxidant
anxiety
Bellis perennis
ethanolic extract
description Acute toxicity, antioxidant activity in vitro and general pharmacological effects of the flower crude ethanolic extract of Bellis perennis L., Asteraceae, a popular medicine used in South America, were investigated in mice. The oral route LD50 value was found 2.31 g/kg. Oral administration at doses 50, 100 and 150 mg/kg of the extract neither caused significant changes in general behavior nor led to toxic symptoms. Anxiolytic-like properties were studied in the open field test and the possible antidepressant-like actions were evaluated in the forced swimming test (FST). There is a significant decrease in the number of crossings at all dosages mentioned above, but no sedative effects at any dosages when compared to controls. In the FST, the extract dosage of 150 mg/kg was effective in reducing immobility, along with a significant increase in swimming time. The ethanolic extract showed strong antioxidant potential in vitro, through the removal capacity against hydroxyl radicals and nitric oxide as well as prevented the formation of reactive substances to thiobarbituric acid (TBARS). Together, these results indicate that the ethanolic extract has effect on central nervous system, which might due to its antioxidant property, as demonstrated in vitro methods used. These results suggest that some of the components in ethanolic extract of B. perennis, such as alkaloids, phenolic compounds and flavonoids may have antioxidant, anxiolytic and antidepressant-like properties. Additional investigations are in progress.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000500016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2012005000082
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.22 n.5 2012
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
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institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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