Maternal exposure to Cochlospermum regium: a toxicological evaluation

Detalhes bibliográficos
Autor(a) principal: Cunha-Laura,Andréa Luiza
Data de Publicação: 2013
Outros Autores: Oliveira,Rodrigo Juliano, Barros,Andrea Lantieri Correa de, Siqueira,João Máximo de, Vieira,Maria do Carmo, Auharek,Sarah Alves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Farmacognosia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200025
Resumo: Cochlospermum regium (Schrank) Pilg., Bixaceae, is a Brazilian plant widely used as a folk medicine in the southwestern of the Brazil to treat inflammation and infection diseases. However, the effects of C. regium hydroethanolic extract on pregnant rats have not been assessed. To evaluate the effects of the C. regium on pregnant rats during the organogenic period, the hydroethanolic extract was administered via gavage at a dose of 11.5 mg/kg/day to rats from 6th to 15th day of pregnancy. No clinical signs of maternal toxicity were observed. The placenta's and fetuses' weight were similar in control and treated animals. The term fetuses dis not present malformations or anomalies although the number of live fetuses and birth rate were significantly decreased. In conclusion, the C. regium hydroethanolic extract is nontoxicant to the pregnant rat although it would be likely to interfere in the progress of the embryofetal development.
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spelling Maternal exposure to Cochlospermum regium: a toxicological evaluationCochlospermum regiummedicinal plantspregnant ratCochlospermum regium (Schrank) Pilg., Bixaceae, is a Brazilian plant widely used as a folk medicine in the southwestern of the Brazil to treat inflammation and infection diseases. However, the effects of C. regium hydroethanolic extract on pregnant rats have not been assessed. To evaluate the effects of the C. regium on pregnant rats during the organogenic period, the hydroethanolic extract was administered via gavage at a dose of 11.5 mg/kg/day to rats from 6th to 15th day of pregnancy. No clinical signs of maternal toxicity were observed. The placenta's and fetuses' weight were similar in control and treated animals. The term fetuses dis not present malformations or anomalies although the number of live fetuses and birth rate were significantly decreased. In conclusion, the C. regium hydroethanolic extract is nontoxicant to the pregnant rat although it would be likely to interfere in the progress of the embryofetal development.Sociedade Brasileira de Farmacognosia2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200025Revista Brasileira de Farmacognosia v.23 n.2 2013reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIA10.1590/S0102-695X2013005000005info:eu-repo/semantics/openAccessCunha-Laura,Andréa LuizaOliveira,Rodrigo JulianoBarros,Andrea Lantieri Correa deSiqueira,João Máximo deVieira,Maria do CarmoAuharek,Sarah Alveseng2013-03-27T00:00:00Zoai:scielo:S0102-695X2013000200025Revistahttp://www.sbfgnosia.org.br/revista/https://old.scielo.br/oai/scielo-oai.phprbgnosia@ltf.ufpb.br1981-528X0102-695Xopendoar:2013-03-27T00:00Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)false
dc.title.none.fl_str_mv Maternal exposure to Cochlospermum regium: a toxicological evaluation
title Maternal exposure to Cochlospermum regium: a toxicological evaluation
spellingShingle Maternal exposure to Cochlospermum regium: a toxicological evaluation
Cunha-Laura,Andréa Luiza
Cochlospermum regium
medicinal plants
pregnant rat
title_short Maternal exposure to Cochlospermum regium: a toxicological evaluation
title_full Maternal exposure to Cochlospermum regium: a toxicological evaluation
title_fullStr Maternal exposure to Cochlospermum regium: a toxicological evaluation
title_full_unstemmed Maternal exposure to Cochlospermum regium: a toxicological evaluation
title_sort Maternal exposure to Cochlospermum regium: a toxicological evaluation
author Cunha-Laura,Andréa Luiza
author_facet Cunha-Laura,Andréa Luiza
Oliveira,Rodrigo Juliano
Barros,Andrea Lantieri Correa de
Siqueira,João Máximo de
Vieira,Maria do Carmo
Auharek,Sarah Alves
author_role author
author2 Oliveira,Rodrigo Juliano
Barros,Andrea Lantieri Correa de
Siqueira,João Máximo de
Vieira,Maria do Carmo
Auharek,Sarah Alves
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha-Laura,Andréa Luiza
Oliveira,Rodrigo Juliano
Barros,Andrea Lantieri Correa de
Siqueira,João Máximo de
Vieira,Maria do Carmo
Auharek,Sarah Alves
dc.subject.por.fl_str_mv Cochlospermum regium
medicinal plants
pregnant rat
topic Cochlospermum regium
medicinal plants
pregnant rat
description Cochlospermum regium (Schrank) Pilg., Bixaceae, is a Brazilian plant widely used as a folk medicine in the southwestern of the Brazil to treat inflammation and infection diseases. However, the effects of C. regium hydroethanolic extract on pregnant rats have not been assessed. To evaluate the effects of the C. regium on pregnant rats during the organogenic period, the hydroethanolic extract was administered via gavage at a dose of 11.5 mg/kg/day to rats from 6th to 15th day of pregnancy. No clinical signs of maternal toxicity were observed. The placenta's and fetuses' weight were similar in control and treated animals. The term fetuses dis not present malformations or anomalies although the number of live fetuses and birth rate were significantly decreased. In conclusion, the C. regium hydroethanolic extract is nontoxicant to the pregnant rat although it would be likely to interfere in the progress of the embryofetal development.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200025
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000200025
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-695X2013005000005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
publisher.none.fl_str_mv Sociedade Brasileira de Farmacognosia
dc.source.none.fl_str_mv Revista Brasileira de Farmacognosia v.23 n.2 2013
reponame:Revista Brasileira de Farmacognosia (Online)
instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron:SBFGNOSIA
instname_str Sociedade Brasileira de Farmacognosia (SBFgnosia)
instacron_str SBFGNOSIA
institution SBFGNOSIA
reponame_str Revista Brasileira de Farmacognosia (Online)
collection Revista Brasileira de Farmacognosia (Online)
repository.name.fl_str_mv Revista Brasileira de Farmacognosia (Online) - Sociedade Brasileira de Farmacognosia (SBFgnosia)
repository.mail.fl_str_mv rbgnosia@ltf.ufpb.br
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