Antinociceptive effect of the ethanolic extract of Amburana cearensis (Allemão) A.C. Sm., Fabaceae, in rodents

• Autor(a) principal: Oliveira,Rafael R. B.
• Data de Publicação: 2009
• Outros Autores: Góis,Rebecca M. O., Siqueira,Rosana S., Almeida,Jackson R. G. S., Lima,Julianeli T., Nunes,Xirley P., Oliveira,Viseldo R., Siqueira,Jullyana S., Quintans-Júnior,Lucindo J.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Brasileira de Farmacognosia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2009000500004
• topic: Amburana cearensis; Fabaceae; antinociceptive activity; medicinal plant

The ethanolic extract of the trunk bark of Amburana cearensis (EEA) was examined for its oral (p.o.) analgesic activity at the doses of 100, 200 and 400 mg/kg body weight. In the acetic acid-induced writhing test, the EEA (200 and 400 mg/kg, p.o.) reduced the number of writhing by 33.4% and 40.7%, respectively. Additionally, EEA (100, 200 and 400 mg/kg, p.o.) decreased by 77.5%, 79.7 and 91.3%, respectively, the paw liking time in the second phase of the formalin test. Therefore, EEA showed a dose-dependent analgesic effect in formalin test and was effective in reducing writhing in mice.